Recollection and familiarity in dense hippocampal amnesia: A case study

Cipolotti, Lisa; Bird, Chris M.; Good, Tina; MacManus, David; Rudge, Peter; Shallice, Tim

doi:10.1016/j.neuropsychologia.2005.05.014

Cited by 106 publications

(108 citation statements)

References 99 publications

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“…Subsequently, three single-case studies and one group study (n = 3) also reported spared memory for faces after hippocampal lesions and impaired memory for other kinds of nonverbal material (e.g., buildings or scenes) (13)(14)(15)(16). The evidence for sparing of face recognition became even stronger when scores on the Recognition Memory Test [RMT, a standard memory test for faces and words (17)] were brought together for 10 patients with hippocampal lesions from earlier studies (18).…”

mentioning

confidence: 99%

When recognition memory is independent of hippocampal function

Smith

Jeneson

Frascino

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance Hippocampal damage has been thought to impair memory for all domains of material (sounds, objects, words, odors). We investigated face recognition memory in patients with hippocampal lesions or large medial temporal lobe lesions. Recognition of novel faces was unequivocally intact in hippocampal patients but only at a short retention interval. Recognition memory for words, buildings, famous faces, and inverted faces was impaired. For medial temporal lobe patients, memory was impaired in all conditions. Ordinarily, recognition memory judgments depend on an association between study items and the study context. We suggest that face memory is spared because face processing is specialized (and holistic), and that participants can make recognition judgments without making explicit reference to the study context.

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mentioning

confidence: 99%

When recognition memory is independent of hippocampal function

Smith

Jeneson

Frascino

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…Whereas many studies report a disproportionate effect of hippocampal damage on recollection and associative memory relative to familiarity (Huppert and Piercy 1978;VarghaKhadem et al 1997;Holdstock et al 2002;Yonelinas et al 2002;Giovanello et al 2003;Mayes et al 2004;Aggleton et al 2005), other reports find that hippocampal damage impacts familiarity and recollection to a similar extent (Manns and Squire 1999;Stark et al 2002;Manns et al 2003;Cipolotti et al 2006;Wais et al 2006;Jeneson et al 2010;Kirwan et al 2010;Song et al 2011). Interestingly, a patient with significant perirhinal damage that spared the hippocampus showed impaired familiarity and preserved recollection (Bowles et al 2007).…”

Section: Hippocampus and Mtlmentioning

confidence: 99%

Memory Retrieval in Mice and Men

Ben-Yakov

Dudai

Mayford

2015

Cold Spring Harb Perspect Biol

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Retrieval, the use of learned information, was until recently mostly terra incognita in the neurobiology of memory, owing to shortage of research methods with the spatiotemporal resolution required to identify and dissect fast reactivation or reconstruction of complex memories in the mammalian brain. The development of novel paradigms, model systems, and new tools in molecular genetics, electrophysiology, optogenetics, in situ microscopy, and functional imaging, have contributed markedly in recent years to our ability to investigate brain mechanisms of retrieval. We review selected developments in the study of explicit retrieval in the rodent and human brain. The picture that emerges is that retrieval involves coordinated fast interplay of sparse and distributed corticohippocampal and neocortical networks that may permit permutational binding of representational elements to yield specific representations. These representations are driven largely by the activity patterns shaped during encoding, but are malleable, subject to the influence of time and interaction of the existing memory with novel information.

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“…Other methods have also been used to assess recollection and familiarity in hippocampal patients or patients with damage to Recognition memory and the hippocampus www.learnmem.org related structures (e.g., recall vs. recognition, remember vs. know, ROC analysis, structural equation modeling, the process-dissociation procedure, item memory vs. source memory, event-related potential indices of recollection), and the results have been variable and often depend on single cases (Düzel et al 2001;Yonelinas et al 2002;Holdstock et al 2002Holdstock et al , 2005Mayes et al 2002Mayes et al , 2004Manns et al 2003;Bastin et al 2004;Quamme et al 2004;Aggleton et al 2005;Barbeau et al 2005;Cipolotti et al 2006;Wais et al 2006;Tsivilis et al 2008;Turriziani et al 2008;Vann et al 2008;Verfaellie et al 2008). Although some of these studies have presented evidence suggesting that the hippocampus selectively subserves recollection, many of them used controversial methods that may confound the assessment of recollection and familiarity with the assessment of strong and weak memories (see Wixted 2009).…”

Section: Patientsmentioning

confidence: 99%

Recognition memory and the hippocampus: A test of the hippocampal contribution to recollection and familiarity

Jeneson

Kirwan²,

Hopkins³

et al. 2010

Learn. Mem.

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It has been suggested that the hippocampus selectively supports recollection and that adjacent cortex in the medial temporal lobe can support familiarity. Alternatively, it has been suggested that the hippocampus supports both recollection and familiarity. We tested these suggestions by assessing the performance of patients with hippocampal lesions on recognition memory tests that differ in the extent to which recollection and familiarity contribute to the recognition decision. When targets and foils are highly similar, prior evidence suggests that, on a forced-choice test in which targets are presented together with highly similar, corresponding foils (the FC-C format), performance is supported primarily by familiarity. By contrast, when targets are presented together with foils that are similar to other targets (the FC-NC format) or when memory is tested in a yes/no (Y/N) format, performance is based much more strongly on recollection. Accordingly, a finding that hippocampal damage impaired both Y/N recognition and FC-NC recognition but spared FC-C recognition would suggest that the hippocampus selectively supports recollection. We administered Y/N, FC-C, and FC-NC tests to five memory-impaired patients with circumscribed hippocampal lesions and 14 controls. The patients were impaired on all three types of recognition test, and there was no indication that the patients were disproportionately benefited or disproportionately impaired on any test. This pattern of performance suggests that the hippocampus supports both recollection and familiarity.

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Recollection and familiarity in dense hippocampal amnesia: A case study

Cited by 106 publications

References 99 publications

When recognition memory is independent of hippocampal function

When recognition memory is independent of hippocampal function

Memory Retrieval in Mice and Men

Recognition memory and the hippocampus: A test of the hippocampal contribution to recollection and familiarity

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