Recognizing the impact of ambient air pollution on skin health

Mancebo, Silvia E.; Wang, S. Q.

doi:10.1111/jdv.13250

Cited by 148 publications

(171 citation statements)

References 37 publications

(88 reference statements)

Supporting

Mentioning

168

Contrasting

Order By: Relevance

“…AhR is activated for example by environmental pollutants, mainly dioxins and PAHs, and takes part in the biochemical signaling cascade and toxic effects of these pollutants. It is also involved in processes such as cell growth, proliferation, and differentiation [13,30]. Tauchi et al (2005) showed that activation of the AhR in keratinocytes in transgenic mice caused inflammatory skin lesions and immunological imbalance, revealed as skin rashes and itches similar to those observed during atopic dermatitis [32].…”

Section: Activation Of the Aryl Hydrocarbon Receptor (Ahr)mentioning

confidence: 99%

“…The alterations of microflora, oxidative stress, and the activation of AhR cause the induction of an inflammatory cascade in the skin. The increased production of pro-inflammatory cytokines, such as interleukin1β or interleukin 8, greatly impacts the biological function of the cells, resulting in skin lesions and deterioration of skin appearance [13]. Pollution also causes a negative impact on other skin properties, which are necessary for proper skin function and health.…”

Section: Effect Of Pollutants On the Skin And Its Mechanism Of Actionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

et al. 2018

View full text Add to dashboard Cite

Exposure to pollution can cause oxidative stress, premature ageing, inflammation, and diseases. Since most of us are exposed to pollution, protection is important. This can be achieved through skin protection or through protection with respect to food and food supplements. There is a wide range of products on the market with anti-pollution claims. However, it is important that these claims are thoroughly validated by proper efficacy testing. When skin cells are exposed to pollution factors, changes in a number of skin properties can be observed, such as lipid composition, lipid and protein oxidation, pH, sebum secretion rate, oxidative stress, inflammation markers, and collagen and elastin levels. These can be measured and used as markers to verify anti-pollution claims. In the present review, we summarize some of the most important in vitro and in vivo tests that are used to determine if an ingredient or formulation has anti-pollution efficacy.

show abstract

Section: Activation Of the Aryl Hydrocarbon Receptor (Ahr)mentioning

confidence: 99%

Section: Effect Of Pollutants On the Skin And Its Mechanism Of Actionmentioning

confidence: 99%

The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The generation of ROS and induction of oxidative stress is implicated as one of the mechanisms by which particulate matter exert their deleterious effects [30]. Particles measuring <0.1 µm in diameter are defined as ultrafine particles and are associated with vehicle exhaust emissions [31]. Ultrafine particles are particularly harmful due to their ability to penetrate tissues more easily and localise in the mitochondria [32].…”

Section: Environmental Pollutionmentioning

confidence: 99%

Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin

Naidoo

Birch‐Machin

2017

Cosmetics

View full text Add to dashboard Cite

Skin ageing is a complex process that is determined by both intrinsic and extrinsic factors, which leads to a progressive loss of structure and function. There is extensive evidence indicating that oxidative stress induced by reactive oxygen species plays an important role in the process of human skin ageing. Mitochondria are the major source of cellular oxidative stress and are widely implicated in cutaneous ageing. Extrinsic skin ageing is driven to a large extent by environmental factors and external stressors such as ultraviolet radiation (UVR), pollution and lifestyle factors which have been shown to stimulate the production of reactive oxygen species and generate oxidative stress. The oxidative damage from these exogenous sources can impair skin structure and function, leading to the phenotypic features of extrinsic skin ageing. The following review highlights the current evidence surrounding the role of mitochondria and oxidative stress in the ageing process and the influence of environmental factors such as ultraviolet radiation, pollution and diet on skin ageing.

show abstract

“…The following are four mechanisms [16] by which ambient air pollutants cause adverse effects on skin health: (i) generation of free radicals, (ii) induction of inflammatory cascade and subsequent impairment of skin barrier, (iii) activation of the aryl hydrocarbon receptor (AhR) and (iv) alterations to skin microflora. The effect of pollutant on skin indications are summarized in Table 2.…”

Section: Pollution and Its Effect On The Skinmentioning

confidence: 99%

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Sawant¹

2018

Cosmetics

View full text Add to dashboard Cite

Abstract:Pollution from air and sunlight has adverse effects on human health, particularly skin health. It creates oxidative stress, which results in skin diseases, including skin cancer and aging. Different types of antioxidants are used as preventative actives in skin-care products. However, they have some limitations as they also scavenge oxygen. Recently, spin traps are being explored to trap free radicals before these radicals generating more free radicals (cascading effect) and not the oxygen molecules. However, not all spin traps can be used in the topical cosmetic skin-care products due to their toxicity and regulatory issues. The present review focuses on the different pathways of reactive oxygen species (ROS) generation due to pollution and the potential use of spin traps in anti-pollution cosmetics to control ROS.

show abstract

Recognizing the impact of ambient air pollution on skin health

Cited by 148 publications

References 37 publications

The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Contact Info

Product

Resources

About