Recognizing nucleotides by cross-tunneling currents for DNA sequencing

Bagci, V. M. K.; Kaun, Chao-Cheng

doi:10.1103/physreve.84.011917

Cited by 13 publications

(10 citation statements)

References 31 publications

(49 reference statements)

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“…The idea of this 'recognition tunneling' originates from successful experiments performed to slow down DNA while it moves through a gap [52][53][54]. Much efforts were focussed on measuring DNA with metallic tunneling electrodes embedded in silicon nitride pores [52,[55][56][57][58][59], and indeed, some sequence information could be extracted when the DNA was pulled through the gap by an electric field [56,57].…”

Section: Tunneling Across a Graphene Nanogapmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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Fast, cheap, and reliable DNA sequencing could be one of the most disruptive innovations of this decade as it will pave the way for personalised medicine. In pursuit of such technology, a variety of nanotechnology-based approaches have been explored and established including sequencing with nanopores. Due to its unique structure and properties, graphene provides interesting opportunities for the development of a new sequencing technology. In recent years, a wide range of creative ideas for graphene sequencers have been theoretically proposed and the first experimental demonstrations have begun to appear. Here, we review the different approaches to using graphene nanodevices for DNA sequencing, which involve DNA passing through graphene nanopores, nanogaps, and nanoribbons, and the physisorption of DNA on graphene nanostructures. We discuss the advantages and problems of each of these key techniques, and provide a perspective on the use of graphene in future DNA sequencing technology.

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Section: Tunneling Across a Graphene Nanogapmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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“…In this context, there was a proposal to use two sets of Au electrodes with different gap sizes and their cross arrangement for simultaneous reading (Bagci and Kaun 2011).…”

Section: Dna Sequencing Based On Metal Electrodesmentioning

confidence: 99%

Recent progress in atomistic simulation of electrical current DNA sequencing

Kim

2015

Biosensors and Bioelectronics

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We review recent advances in the DNA sequencing based on the measurement of transverse electrical currents. Device configurations proposed in the literature are classified according to whether the molecular fingerprints appear as the major (Mode I) or perturbing (Mode II) current signals. Scanning tunneling microscope and tunneling electrode gap configurations belong to the former category, while the nanochannels with or without an embedded nanopore belong to the latter. The molecular sensing mechanisms of Modes I and II roughly correspond to the electron tunneling and electrochemical gating, respectively. Special emphasis will be given on the computer simulation studies, which have been playing a critical role in the initiation and development of the field. We also highlight low-dimensional nanomaterials such as carbon nanotubes, graphene, and graphene nanoribbons that allow the novel Mode II approach. Finally, several issues in previous computational studies are discussed, which points to future research directions toward more reliable simulation of electrical current DNA sequencing devices.

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“…This technique improves transverse communication through base pairs [5]. Nucleotides through the cross‐tunnelling effect of DNA sequencing has also been recognised [6]. Transverse edge current of DNA sequence is analysed using graphene nano‐ribbon [7].…”

Section: Introductionmentioning

confidence: 99%

Electronic enhancement effect of doped ferromagnetic material in biomolecular heterojunction switch

Dey

Roy

2018

IET Circuits, Devices & Systems

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Density functional theory conjugated with non-equilibrium Green's function-based first principle approach is used to determine the ferromagnetic-doping effect in the current-voltage characteristics for the heterojunction biomolecular analytical structure. The quantum-mechanical transport phenomenon and multiple switching activities associated with sequential negative differential resistance properties have been observed for this adenine-thymine chain. The authors investigate the quantumtransport properties of conventional doping effect for ferromagnetic atoms in this bimolecular chain. The results show an electronic enhancement effect in quantum-ballistic conductivity for this chain along with sequential switching property. Among these ferromagnetic metals, Nickel shows significant transmission spectrum, sharp and prominent highest occupied molecular orbital (MO) and lowest unoccupied MO peak along with maximum quantum-ballistic current at room temperature. It is observed from the device density of states that large numbers of conducting channels are available for Nickel doping. This ensures high quantum-transmission current flow within the central molecular region for these ferromagnetic dopants. Compared to Iron and Cobalt, the current has been enhanced up to 4.05 times for Nickel dopant. High doping concentration (13.3%) has been introduced for this ab-initio model. It has found that the number of total switching process is increased during ferromagnetic doping mainly for Cobalt and Nickel dopants.

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Recognizing nucleotides by cross-tunneling currents for DNA sequencing

Cited by 13 publications

References 31 publications

Graphene nanodevices for DNA sequencing

Graphene nanodevices for DNA sequencing

Recent progress in atomistic simulation of electrical current DNA sequencing

Electronic enhancement effect of doped ferromagnetic material in biomolecular heterojunction switch

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