Recognizing Degenerative Aging as a Treatable Medical Condition: Methodology and Policy

Stambler, Ilia

doi:10.14336/ad.2017.0130

Cited by 55 publications

(30 citation statements)

References 39 publications

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“…Likewise, the use of drugs in the fight against ageing has several significant limitations (Chmielewski 2019a;Rattan 2019). These theoretical problems notwithstanding, many researchers classify ageing as a disease (Bulterijs et al 2015;Gems 2015;Stambler 2015Stambler , 2017 and promote 'anti-ageing' drugs (Blagosklonny 2017, 2018), even though most of these methods seem incongruous from an evolutionary standpoint. Nevertheless, it is possible that ageing as a dynamic and plastic process can be modulated using more sophisticated methods in the future (cf.…”

Section: Can Drugs Delay the Onset Of Ageing-associated Pathologies?mentioning

confidence: 99%

The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

Chmielewski

2020

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Ageing is one of the most complex and difficult problems for humans to face and for science to solve. Although human senescence was viewed as a passive and uncontrollable process of deterioration over time with little or no genetic regulation, the concept that ageing is caused by both genetic and environmental factors is now generally accepted, even though it remains difficult to distinguish between ageing sensu stricto and the effects of age-related diseases. Empirical data show that mechanisms of ageing are highly conserved during evolution. Moreover, it has been established that there are specific molecular ‘instructions’ for ageing, which suggests that a better understanding of the molecular biology of ageing will open new possibilities regarding future interventions. The complexity of ageing diminishes the possibility that any general theory will completely explain this metaphenomenon. Likewise, it is highly unlikely that any medication can stop or reverse human senescence. Nevertheless, ageing as a dynamic and malleable metaphenomenon can be modulated by a variety of influences. The concept of the shrinkage of the homeo-dynamic space with age, i.e. homeostenosis, is especially interesting and intriguing as it shows that novel therapeutic approaches and rational strategies can help delay the onset of the ageing-associated pathologies by enhancing the homeodynamic capabilities of the body. The aim of this article is to present current data from evolutionary and molecular gerontology and discuss them within the ambit of this review which is devoted to the dynamic, emergent and plastic nature of human ageing and implications for future interventions.

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Section: Can Drugs Delay the Onset Of Ageing-associated Pathologies?mentioning

confidence: 99%

The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

Chmielewski

2020

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“…The answer to this question is not easy, even if intuitively some would say "yes, aging is a disease and as such may be cured" (Caplan, 2005;Bulterijs et al, 2015;Zhavoronkov and Bhullar, 2015;Stambler, 2017) while others will say "not at all, aging is not a disease although it may be modulated" (Rattan, 2014). Even if this distinction seems trivial, it has many consequences for science and translational research.…”

Section: What May Be the Reason That Aging Is Considered As A Disease?mentioning

confidence: 99%

Are We Ill Because We Age?

et al. 2019

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Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an increasingly serious health and socioeconomic concern for modern societies. Science has made tremendous progress in the understanding of aging itself, which has helped medicine to extend life expectancies. With the increase of the life expectancy, the incidence of chronic age-related diseases (ARDs) has also increased. A new approach trying to solve this problem is the concept of geroscience. This concept implies that the aging process itself is the common cause of all ARDs. The corollary and consequence of such thinking is that we can and should treat aging itself as a disease. How to translate this into the medical practice is a big challenge, but if we consider aging as a disease the problem is solved. However, as there is no common definition of what aging is, what its causes are, why it occurs, and what should be the target(s) for interventions, it is impossible to conclude that aging is a disease. On the contrary, aging should be strongly considered not to be a disease and as such should not be treated; nonetheless, aging is likely amenable to optimization of changes/adaptations at an individual level to achieve a better functional healthspan.

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“…It is well known that chronic non-communicable diseases have been the major contributors to the disease burden, among which age-related diseases such as diabetes, cardiovascular disease, and cancer diseases have become the leading causes of morbidity and mortality worldwide [2][3][4][5][6][7][8][9] . Moreover, these diseases could not only affect the life quality of the elderly, but also the family members who take care them 10 . So how to prevent the age-related diseases and how can people achieve the condition of healthy aging?…”

Section: Introductionmentioning

confidence: 99%

Establishing a Comprehensive Anti-aging Research Center: Experiences and Challenges

Chen¹,

Ge²,

Huang³

et al. 2020

Preprint

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Introduction: Age-related diseases have become the leading causes of morbidity and mortality worldwide. Anti-aging researches both at the population and individual levels are still urgently needed. Establishing comprehensive anti-aging research centers is crucial to advancing anti-aging researches. However, few studies have shown guidelines for establishing a comprehensive anti-aging research center. We aim to describe the establishment of a comprehensive anti-aging center, summarize the initial experiences, and discuss limitations, strengths and challenges. Methods: The establishment contains three phases (from October, 2017 to January, 2020), the first phase is assessing the need for anti-aging research by reviewing relevant literatures and investigating the elderly population. The second phase is interpreting the aging-related policies by searching and analyzing China's aging-related policies in recent years on government websites. The third phase is completing the protocol of establishing the center, raising funds for the establishment of the center and selecting the adequate equipment. Results: In phase one, we find improving strategies at the population and individual levels are still needed. Through establishing elderly cohort, we find that many elderly people are with high risk factors of aging. In phase two, we find many age-related policies have been unveiled. In phase three, we complete the protocol of establishing the center based on the results of phase one and two. We also have raised funds and selected equipment for the center. Conclusion: With limited guideline for establishing a comprehensive anti-aging research center, the experience in this paper might help other institutions to build anti-aging research center or program. KEY WORDS: anti-aging; research center; establishing; experience; challenge

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Recognizing Degenerative Aging as a Treatable Medical Condition: Methodology and Policy

Cited by 55 publications

References 39 publications

The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

Are We Ill Because We Age?

Establishing a Comprehensive Anti-aging Research Center: Experiences and Challenges

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