Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging

Abstract

In our study, FDB had wide skeletal distribution with variability of 18F-FDG uptake and CT appearance. SUV in the delayed stage was seen to either decrease or increase on dual-time 18F-FDG PET scanning. It is very important to recognize the characteristics of this skeletal dysplasia to allow differentiation from skeletal metastasis.

Prospective Study Evaluating Na18F PET/CT in Predicting Clinical Outcomes and Survival in Advanced Prostate Cancer

“…The ability of Na 18 F PET/CT to detect skeletal metastases has been evaluated in various types of cancer, including prostate cancer, and a series of studies has reported improved sensitivity and specificity compared with 99m Tc-BS (7)(8)(9)(10)(11)(12)(13). In 2011, the Food and Drug Administration approved a new-drug application for Na 18 F PET/CT from the National Cancer Institute; however, its routine clinical use is not yet defined.…”

“…99m Tc-methylene diphosphonate bone scanning ( 99m Tc-BS) is currently the most widely used method for detecting bone metastasis; however, Na 18 F PET combined with CT has higher sensitivity and specificity.…”

“…Na 18 F PET/CT provides rapid (within 1 h), bone-specific uptake and blood clearance and excellent visualization of the axial skeleton. The ability of Na 18 F PET/CT to detect skeletal metastases has been evaluated in various types of cancer, including prostate cancer, and a series of studies has reported improved sensitivity and specificity compared with 99m Tc-BS (7)(8)(9)(10)(11)(12)(13).…”

Fibrous Dysplasia Mimicking Bone Metastasis on Both Bone Scintigraphy and 18F-FDG PET-CT: Diagnostic Dilemma in a Patient with Breast Cancer

“…Unfortunately, similar to bone scintigraphy, benign bone conditions can also show increased 18 F-FDG uptake on PET-CT, and PET-positive asymptomatic fibrous dysplasia can be misinterpreted as a metastasis [4]. Fibrous dysplasia of bone has wide skeletal distribution, with variability of 18 F-FDG uptake and CT appearance [5,6]. It is therefore important to recognize the characteristics of this skeletal dysplasia, to allow differentiation from skeletal metastasis [6,7].…”

“…Fibrous dysplasia of bone has wide skeletal distribution, with variability of 18 F-FDG uptake and CT appearance [5,6]. It is therefore important to recognize the characteristics of this skeletal dysplasia, to allow differentiation from skeletal metastasis [6,7]. Bone lesions with 18 F-FDG uptake need to be carefully interpreted when evaluating patients with known malignancy [8].…”