Recognition‐Mediated Hydrogel Swelling Controlled by Interaction with a Negative Thermoresponsive LCST Polymer

Belal, Khaled; Stoffelbach, François; Lyskawa, Joël; Fumagalli, Matthieu; Hourdet, Dominique; Marcellan, Alba; Smet, Lieselot De; Rosa, Victor Retamero De La; Cooke, Graeme; Hoogenboom, Richard; Woisel, Patrice

doi:10.1002/ange.201605630

Cited by 12 publications

(4 citation statements)

References 39 publications

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“…[ 132 ] The typical temperature responsive supramolecular hydrogel system is reported in which the change in hydrogel volume is due to the formation of a host–guest complex, resulting in charge repulsion and change in osmotic pressure between the host units. [ 133 ]…”

Section: Assembled Principle Of Bioinspired Supramolecular Hydrogelsmentioning

confidence: 99%

Bioinspired Supramolecular Hydrogel from Design to Applications

Gao,

Yang,

Song

2023

Small Methods

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Nature offers a wealth of opportunities to solve scientific and technological issues based on its unique structures and function. The dynamic non‐covalent interaction is considered to be the main base of living functions of creatures including humans, animals, and plants. Supramolecular hydrogels formed by non‐covalent bonding interactions has become a unique platform for constructing promising materials for medicine, energy, electronic, and biological substitute. In this review, the self‐assemble principle of supramolecular hydrogels is summarized. Next, the stimulation of external environment that triggers the assembly or disassembly of supramolecular hydrogels are recapitulated, including temperature, mechanics, light, pH, ions, etc. The main applications of bioinspired supramolecular hydrogels in terms of bionic objects including humans, animals, and plants are also described. Although so many efforts are done for revealing the synergized mechanism of the function and non‐covalent interactions on the supramolecular hydrogel, the complexity and variability between stimulus and non‐covalent bonding in the supramolecular system still require impeccable theories. As an outlook, the bioinspired supramolecular hydrogel is just beginning to exhibit its great potential in human life, offering significant opportunities in drug delivery and screening, implantable devices and substitutions, tissue engineering, micro‐fluidic devices, and biosensors.

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Section: Assembled Principle Of Bioinspired Supramolecular Hydrogelsmentioning

confidence: 99%

Bioinspired Supramolecular Hydrogel from Design to Applications

Gao,

Yang,

Song

2023

Small Methods

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“…Covalent hydrogels generally show higher long-term stability and better mechanical properties in comparison to physical hydrogels . Responsive hydrogels can be developed by tuning their physical properties, e.g ., hydrophilic–hydrophobic balance, or by incorporating chemical groups that respond to certain stimuli, such as ionizable groups. − Such responsive hydrogels can undergo stimuli-induced reversible or irreversible sol–gel transitions, structural reorganization and transformation, or self-healing reactions. − …”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Covalent Adaptable Hydrogels Based on Homolytic Bond Dissociation and Chain Transfer Reactions

et al. 2022

Self Cite

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Covalent adaptable hydrogels containing dynamic covalent bonds are gaining significant interest based on their ability of stimuli-controlled reversible bond dissociation, structural reorganization, color change, and self-healing through covalent bond exchange or dissociation. Potential applications of such hydrogels have been explored in coatings, sealants, tissue adhesives, soft robotics, tissue engineering, and stimuli-responsive lithography. Stimuli-induced homolytic bond cleavage leads to the formation of radicals with the ability of recombination or transfer to induce bond exchange and color variation. The incorporation of such stimuli-responsive homolytically cleavable bonds in hydrogels can lead to stimuli-controlled plasticity, stress relaxation, self-healing, structural reorganization, mechanochromism, and mechanoluminescence. The resultant smart materials are interesting for different applications, ranging from patterning and shape-shifting, cell encapsulation and culturing, and protein binding to strain sensing and damage reporting. The recent progress in the preparation of covalently adaptable hydrogels based on stimuli-responsive homolytical bond dissociation and recombination or chain transfer will be discussed in this review. More specifically, the different types of chemistry that can be used for development of covalent adaptable hydrogels based on light-induced, temperature-induced, and mechanically induced homolytic bond dissociation will be discussed. Moreover, the applications of the resultant covalent adaptable hydrogels will be highlighted, focusing on stress sensing and damage reporting, tissue engineering, and self-healable hydrogels, as well as stimuli-controlled patterning and shape-shifting.

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“…Indeed, the colored guest‐specific complexes can be disrupted, on demand, through the application of different stimuli such as temperature, 17 the application of an electrochemical potential 18 or the introduction of a competitive guest molecule 19 . In this way, this electron‐deficient cyclophane cyclobis(paraquat‐ p ‐phenylene) was introduced into thermo‐responsive polymers backbone or hydrogel to construct various smart materials including thermo‐responsive micelles, 20 hydrogels, 21 diblock copolymers 22 and functionalized polymers with memory function 23 …”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive catechol end‐functionalized polymers/CBPQT⁴⁺, 4Cl⁻ supramolecular assembly

Defrançois

Bouad

Woisel

et al. 2022

Journal of Polymer Science

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In the past decade, the adhesive properties of catechol derivatives have inspired researchers for the design of various macromolecular architectures featuring fascinating properties and finding applications in energy storage, coatings, adhesives and biomaterials. In this work, the complexation of catechol end-functionalized polymers prepared by RAFT polymerization was investigated in aqueous media with the electron-deficient tetracationic cyclophane cyclobis(paraquat-p-phenylene) (CBPQT 4+ ) by using UV-Vis and 1 H NMR experiments. The formation of pseudorotaxanes between the catechol end-functionalized polymers and the CBPQT 4+ ,4Cl À leads to the formation of colored guest-specific complexes displaying tunable complexation properties. In particular, we demonstrated that the thermo-responsiveness i.e. the lower critical solution temperature (LCST) of the catechol end-functionalized poly(NIPAM) could be used as a simple and convenient tool to disrupt the complexation with CBPQT 4+ ; 4Cl À resulting in the disappearance of the characteristic color of the Catechol/BB complex while releasing the cyclophane in the aqueous solution. Furthermore, these supramolecular host/guest assemblies could be disrupted, on demand, by the addition of a competitive Naphthalene derivative leading to the appearance of the characteristic purple color of Naphthalene/CBPQT 4+ complexes. These results pave the way for the design of a new generation of stimuli responsive materials with control properties.catechol end-functionalized polymers, CBPQT 4+ , host-guest complexation, thermoresponsive polymers | INTRODUCTIONNature is a fascinating source of inspiration for stimulating research in materials science. Indeed, recent progress in the adhesion mechanism of marine mussels 1 has led to the emergence of a new generation of materials mimicking the properties of these natural systems and finding various applications in coatings, 2 adhesives 3 and biomaterials. 4 In

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Recognition‐Mediated Hydrogel Swelling Controlled by Interaction with a Negative Thermoresponsive LCST Polymer

Cited by 12 publications

References 39 publications

Bioinspired Supramolecular Hydrogel from Design to Applications

Bioinspired Supramolecular Hydrogel from Design to Applications

Stimuli-Responsive Covalent Adaptable Hydrogels Based on Homolytic Bond Dissociation and Chain Transfer Reactions

Thermoresponsive catechol end‐functionalized polymers/CBPQT⁴⁺, 4Cl⁻ supramolecular assembly

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Recognition‐Mediated Hydrogel Swelling Controlled by Interaction with a Negative Thermoresponsive LCST Polymer

Cited by 12 publications

References 39 publications

Bioinspired Supramolecular Hydrogel from Design to Applications

Bioinspired Supramolecular Hydrogel from Design to Applications

Stimuli-Responsive Covalent Adaptable Hydrogels Based on Homolytic Bond Dissociation and Chain Transfer Reactions

Thermoresponsive catechol end‐functionalized polymers/CBPQT4+, 4Cl− supramolecular assembly

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Thermoresponsive catechol end‐functionalized polymers/CBPQT⁴⁺, 4Cl⁻ supramolecular assembly