Recognition and movement of polystyrene nanoplastics in fish cells

Yang, Meng; Wang, Wen‐Xiong

doi:10.1016/j.envpol.2022.120627

Cited by 16 publications

(8 citation statements)

References 68 publications

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“…In addition, we found a slight decrease in the content of G50PS at 6 h in both kinds of cells, which may be caused by cell division. Unlike our results, the cellular uptake of 90 nm PS in the zebrafish cell line ZF4 reached a peak within 2 h and then decreased [ 51 ]. The difference possibly comes from different PS NPs and cell lines.…”

Section: Resultscontrasting

confidence: 94%

“…However, R100PS behaved much differently. The inhibitors, especially MβCD, did not significantly inhibit the uptake of R100PS by A549 cells ( Figure 4 a), inferring that there were other energy-dependent endocytosis pathways, such as the clathrin- and caveolae-independent endocytosis, which is much different from the result of Yang et al [ 51 ]. In BEAS-2B cells, the caveolae-mediated uptake was the main pathway for G50PS, while the clathrin-mediated endocytosis, caveolae-mediated endocytosis, and macropinocytosis contributed comparably to the uptake of R100PS ( Figure 4 b).…”

Section: Resultsmentioning

confidence: 63%

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Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells

Liu

et al. 2022

Nanomaterials

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Nanoplastics, one component of plastic pollution, can enter human bodies via inhalation and thus threaten human health. However, the knowledge about the uptake and exocytosis of nanoplastics in cells of human lung organs is still very limited. Herein, we investigated the endocytosis, distribution, and exocytosis of polystyrene nanoparticles (PS NPs) of 50 nm (G50PS) and 100 nm (R100PS) in A549 cells and BEAS-2B cells. We found that both the cellular uptake of PS NPs increased positively with exposure time and dose, and A549 cells ingested more PS NPs than BEAS-2B cells did. In addition, the intracellular content of G50PS was higher than that of R100PS except at a higher dose and longer time. The ingested PS NPs were distributed mainly in lysosomes, while many G50PS appeared around the cell membrane, and R100PS also accumulated in mitochondria in BEAS-2B cells. As for the exocytosis, R100PS was more difficult to excrete than G50PS. Lysosomes in A549 cells and actin and microtubule in BEAS-2B cells were involved in the exocytosis of the PS NPs. These findings provide detailed information about the translocation of nanoplastics in lung cells, which is valuable for the safety assessment of nanoplastics in the environment.

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Section: Resultscontrasting

confidence: 94%

Section: Resultsmentioning

confidence: 63%

Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells

Liu

et al. 2022

Nanomaterials

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“…120,121 Different types of PSNPs can be transferred to lysosomes via clathrinmediated or caveolae-mediated pathways. 122 More importantly, NPs can reach the nucleus causing DNA damage and genotoxicity. Short-term exposure to a concentration of 100 nm PSNPs induces DNA damage in Mytilus galloprovincialis and affects the expression of genes related to immune functions.…”

Section: Ingested By Aquatic Animalsmentioning

confidence: 99%

Multifaceted Aquatic Environmental Differences between Nanoplastics and Microplastics: Behavior and Fate

Wang,

AL-Hasni,

Liu

et al. 2024

Environ. Health

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Microplastics and nanoplastics are emerging pollutants of concern in the aquatic environment that are causing increasing global environmental and human health problems. Although there has been extensive research on microplastics and nanoplastics, little has been said about the differences in their behavior in the aquatic environment, and many studies have considered them as the same class of hazardous materials; but in fact, microplastics and nanoplastics should be considered as two different types of environmentally hazardous materials. In this review, we propose that microplastics and nanoplastics behave in the aquatic environment in a size-dependent manner and should be distinguished. And we systematically analyzed the differences in the behavior of microplastics and nanoplastics in the aquatic environment in terms of five aspects: 1) distribution behavior; 2) adsorption behavior; 3) reaction with natural colloids; 4) aging and leaching behavior; 5) interaction with organisms. This paper has been written to draw academic attention to the different behaviors of microplastics and nanoplastics in the aquatic environment in order to distinguish between their effects on humans and the environment.

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“…Given the research carried out on eukaryotic cells like animal or human cells (for review see, Zhang et al, 2022a,b), it's reasonable to consider that fungi might also have various mechanisms for internalising NPs into lysosomes (Xu et al, 2021). For instance, negatively charged NPs may escape from lysosomes and influence cellular components to induce stress (Yang and Wang, 2023), while positive NPs destabilise lysosomes promoting a cascade of cellular damage through ROS generation (Zhang et al, 2022a,b). Furthermore, the formation of the eco-corona is also influenced by the surface charge of NPs (Zhang et al, 2022a,b).…”

Section: Cellular Responsesmentioning

confidence: 99%

Does Functionalised Nanoplastics Modulate the Cellular and Physiological Responses of Aquatic Fungi to Metals?

Barros¹,

Kumar

Seena³

2023

Preprint

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Recognition and movement of polystyrene nanoplastics in fish cells

Cited by 16 publications

References 68 publications

Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells

Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells

Multifaceted Aquatic Environmental Differences between Nanoplastics and Microplastics: Behavior and Fate

Does Functionalised Nanoplastics Modulate the Cellular and Physiological Responses of Aquatic Fungi to Metals?

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