Recognising endometrial cancer in pre‐menopausal women

Duska, L.

doi:10.1111/1471-0528.14487

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not find a significant association between diabetes, use of tamoxifen and HRT to FIGO stage at presentation, as for women with higher BMI. Moreover, timing for referral for premenopausal women with AUB is still inconsistent and therefore, in our opinion, there is a clear need to determine the role of risk factors on prognosis and diagnosis of EC in this category of women, despite we acknowledge that the risk of EC in those women is only 0.1% (Duska, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Most national guidelines (The American College of Obstetricians and Gynaecologists Committee Opinion, 2013) (National Institute for Health and Care Excellence, 2018) recommend ES in women older than 45 years with AUB. The New Zealand guidelines advise similarly that ES should be used in women over 45 years of age or with weights >90 kg (Duska, 2017). The Society of Obstetricians and Gynecologists of Canada advise ES in a slightly younger population: women older than 40 years or younger women with additional risk factors such as BMI of >30 mg/kg (Pearson-Stuttard et al, 2018) or nulliparity (The Society of Obstetricians and Gynaecologists of Canada, 2013).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors and sonographic endometrial thickness as predictors of tumour stage and histological subtype of endometrial cancer

Rizzuto

Nicholson

MacNab

et al. 2019

Gynecologic Oncology Reports

View full text Add to dashboard Cite

We evaluated the association between risk factors for endometrial cancer (EC) and sonographic endometrial thickness (ET) with FIGO stages at diagnosis. We also reported our experience in reliability of sonographic ET as screening tool for either histologic subtype I and II of EC. It was a case series study including 339 patients diagnosed with EC from 2010 to 2017 at the Ipswich Hospital, UK. Women with higher body mass index (BMI) presented at earlier stages when compared to women with lower BMIs ( p -value = .046). By contrast, none of the variables: parity ( p -value = .1630), use of HRT ( p -value 0.7448), tamoxifen (p-value 0.0733) and diabetes (p-value = .1665) were statistically associated to FIGO stages. The mean of ET measurement was not statistically significant associated ( p -value 0.0625) to stages. There was no statistic difference on mean ET at diagnosis between histologic subtypes I or II ( p -value 0.804). According to our experience, BMI is associated to FIGO stage and endometrial sampling (ES) should be included in the working diagnosis of EC to obtain an early diagnosis in women with high BMIs even in premenopausal. Ultrasonographic measurement of the endometrium is equally reliable at determining cancer, but not at differentiating histologic subtypes I and II uterine cancers. However, ET does not correlate to FIGO stages at diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk factors and sonographic endometrial thickness as predictors of tumour stage and histological subtype of endometrial cancer

Rizzuto

Nicholson

MacNab

et al. 2019

Gynecologic Oncology Reports

View full text Add to dashboard Cite

show abstract

“…Endometrial cancer is one of the common gynecological malignancies that threaten women's health, 1,2 especially for women in the perimenopausal and postmenopausal period, 3 and the incidence rate has been on the rise in recent years. Atypical endometrial hyperplasia (AEH) is the precancerous lesion for EC, and its pathological morphological manifestation is similar to that of highly differentiated EC 4,5 .…”

Section: Introductionmentioning

confidence: 99%

The Value of Shear Wave Elastography in Predicting the Risk of Endometrial Cancer and Atypical Endometrial Hyperplasia

Yang

Wang

et al. 2021

J of Ultrasound Medicine

View full text Add to dashboard Cite

Objectives To evaluate shear wave elastography (SWE) technology diagnosis value of endometrial cancer (EC) and atypical endometrial hyperplasia (AEH), and to establish predictive logistic regression models for the diagnosis of EC and AEH. Methods Clinical information collection, transvaginal conventional ultrasonography, and SWE check were performed on 122 patients, who were perimenopausal or postmenopausal vaginal bleeding with ≥4.5 mm thick endometrium. The maximal (Emax) and mean (Emean) of Young's modulus for the endometrium were obtained. Using pathology as the gold standard, ROC curves were plotted to evaluate Young's modulus on the diagnostic effectiveness of EC and AEH. Single‐factor analysis and bivariate logistic regression methods were applied to assess the clinical variables, transuaginal conventional ultrasonography variables, and Young's modulus on the identification of EC and AEH. Results Out of 122 cases of endometrial lesions, 85 cases were benign lesions, and the remaining 37 cases were EC and AEH. The Emax and Emean for the benign group were 29.80 ± 11.40 and 17.96 ± 8.05 kPa, respectively. The Emax and Emean values for EC and AEH group were 59.49 ± 16.95 and 38.46 ± 17.10 kPa, respectively. Emax and Emean for both groups were statistically significant, with p <.001. In the logistical regression analysis, endometrial thickness, Color score, and Young's modulus were identified as independent risk factors for EC and AEH. Conclusions SWE technology plays an important role in the diagnosis of EC and AEH, and the diagnostic effectiveness would be higher when combined with conventional ultrasonography.

show abstract