“…Neural circuit computation relies upon action potential transmission, and thus changes in transmission efficacy are vital for information storage. In particular, connectivity between excitatory neurons and local interneurons (feedback inhibition, including lateral inhibition), is believed to gate afferent drive (Fernandez-Ruiz et al, 2017, Milstein et al, 2015, Somogyi and Klausberger, 2005), control local synchrony (Stark et al, 2014), and dictate competitive interactions within the excitatory population (Buzsaki, 2010, Trouche et al, 2016). Therefore, a mechanistic understanding of neural circuit operations requires not only connectomic mapping of circuit elements, but also the elucidation of the parameters that affect the dynamic properties of individual synaptic connections that support circuit computation.…”