Reclassification of a spindle cell sarcoma after identification of a TFG‐ROS1 fusion: A case demonstrating the clinical benefit of next‐generation sequencing in sarcoma
John J. Lim,
Eleanor Y. Chen,
Stephanie K. Schaub
et al.
Abstract:BackgroundInflammatory myofibroblastic tumors (IMTs) are rare mesenchymal soft tissue sarcomas that often present diagnostic challenges due to their wide and varied morphology. A subset of IMTs have fusions involving ALK or ROS1. The role of next‐generation sequencing (NGS) for classification of unselected sarcomas remains controversial.Methods and ResultsWe report a case of a metastatic sarcoma in a 34‐year‐old female originally diagnosed as an unclassified spindle cell sarcoma with myofibroblastic differenti… Show more
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