Reciprocity of exposure time and irradiance on energy density during photoradiation on wound healing in a murine pressure ulcer model

Abstract

Varying irradiance and exposure time to achieve a specified energy density affects phototherapy outcomes in this model. Variation of exposure time and irradiance may account for conflicting results in the literature. Further studies of these effects are warranted.

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

“…Some of the animal studies investigating the effects of LLLT on wound healing have found similar results to the ones found in the in vitro studies, ranging from decreased inflammation and increased collagen and granulation tissue in the wound bed to increased tensile strength and faster epithelization [20][21][22][23].…”

Of diamond surfaces, red light photobiomodulation and fertility: lessons from the laboratory

“…Our laboratory demonstrated that cell proliferation and metabolism in vitro can be influenced by varying the dose frequency or treatment interval of the PBMT (17). We have also demonstrated this same phenomenon as regards wound healing in a murine pressure ulcer model (18). These investigations underscore the concept that a unique dose frequency combination exists for tissues and cell lines and that this specific treatment paradigm must be determined to optimize outcomes and maximally stimulate cellular metabolism and proliferation.…”

“…Light at this wavelength is known to be absorbed by cytochrome C oxidase and other molecules, stimulating ATP synthesis and affecting ROS production, among numerous other activities at the cellular, tissue and whole organism level (16). The caveat however is that the light dose and dose rate are important and that all cell and tissues are not equally responsive to photoradiation (16)(17)(18)(19)(20)(21)(22).…”

“…The classically described PBM treatment window is between 600 and 1,200 nm (16)(17)(18)(19)(20)(21)(22). Light in this portion of the spectrum readily penetrates skin and tissues via the so-called optical window.…”

“…We have learned that all cells and tissues don't respond to PBM and that one size does not fit all when determining the dose or course of treatment (18)(19)(20)(21)(22). Different photobiomodulatory effects have been described depending upon the specific cell lines and species being investigated.…”