Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer

Yu, Xilan; Ma, Rui; Wu, Yinsheng; Zhai, Yansheng; Li, Shanshan

doi:10.3389/fgene.2018.00394

Cited by 45 publications

(31 citation statements)

References 99 publications

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“…4) [47]. Recent evidence demonstrates that metabolic enzymes are able to critically affect epigenetic regulation through activity-catalyzed conversion of metabolic substrates [71]. One example is fumarase (FH), which is located in both mitochondria and the cytosol and mediates the reversible hydration and dehydration of fumarate to malate in the TCA cycle in mitochondria and amino acid and fumarate metabolism in the cytoplasm.…”

Section: Hbp and Transcriptionmentioning

confidence: 99%

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

2019

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Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway (HBP). The HBP culminates in the production of an amino sugar uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) that, along with other charged nucleotide sugars, serves as the basis for biosynthesis of glycoproteins and other glycoconjugates. These nutrient-driven post-translational modifications are highly altered in cancer and regulate protein functions in various cancer-associated processes. In this review, we discuss recent progress in understanding the mechanistic relationship between the HBP and cancer.

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Section: Hbp and Transcriptionmentioning

confidence: 99%

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

2019

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“…In contrast with this observation, where cell metabolites and enzymes modulate epigenetic phenomena, epigenetic modifications at metabolic genes, such as acylation or O-GlcNAcylation may affect cell metabolism. A detailed description of the link between metabolism and epigenetic changes is out of the scope of this review, and has been described extensively by Yu et al (54). Summarized, it seems that epigenetic modifications and cellular metabolism interact with each other and that their relationship is reciprocal.…”

Section: Metabolic Pathways Emanating From Glycolysismentioning

confidence: 99%

The Metabolic Landscape of Lung Cancer: New Insights in a Disturbed Glucose Metabolism

et al. 2019

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Metabolism encompasses the biochemical processes that allow healthy cells to keep energy, redox balance and building blocks required for cell development, survival, and proliferation steady. Malignant cells are well-documented to reprogram their metabolism and energy production networks to support rapid proliferation and survival in harsh conditions via mutations in oncogenes and inactivation of tumor suppressor genes. Despite the histologic and genetic heterogeneity of tumors, a common set of metabolic pathways sustain the high proliferation rates observed in cancer cells. This review with a focus on lung cancer covers several fundamental principles of the disturbed glucose metabolism, such as the “Warburg” effect, the importance of the glycolysis and its branching pathways, the unanticipated gluconeogenesis and mitochondrial metabolism. Furthermore, we highlight our current understanding of the disturbed glucose metabolism and how this might result in the development of new treatments.

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“…Of note, there is a bidirectional relationship between epigenetic modifications and metabolic changes. On one hand, intermediary metabolites and metabolic enzymes regulate epigenetic modifications; on the other hand, epigenetic changes at promoter regions of the metabolic genes modulate the gene expression involved in metabolism, which eventually affects intracellular metabolism [43,83,84]. Sensing the microenvironment status with subsequent reprogramming of intracellular metabolism is the driving force to shift the epigenetic landscape, and the timely expression of metabolic genes via epigenetics to respond to the micro-environment would be reasonable, in that the feedback regulation of metabolism could enable cells to respond to changes in microenvironment in a prompt and accurate way.…”

Section: Epigenetic Regulation Of Iron Metabolism: Mutual Dependementioning

confidence: 99%

Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review

Masui

Cavenee

Mischel

et al. 2020

Acta Histochem. Cytochem.

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Cancer is widely considered to be a set of genetic diseases that are currently classified by tissue and cell type of origin and, increasingly, by its molecular characteristics. This latter aspect is based primarily upon oncogene gains, tumor suppressor losses, and associated transcriptional profiles. However, cancers are also characterized by profound alterations in cellular metabolism and epigenetic landscape. It is particularly noteworthy that cancercausing genomic defects not only activate cell cycle progression, but regulate the opportunistic uptake and utilization of nutrients, effectively enabling tumors to maximize growth and drug resistance in changing tissue and systemic microenvironments. Shifts in chromatin architecture are central to this dynamic behavior. Further, changes in nutrient uptake and utilization directly affect chromatin structure. In this review, we describe a set of recent discoveries of metabolic and epigenetic reprogramming in cancer, and especially focus on the genomically well-characterized brain tumor, glioblastoma. Further, we discuss a new mode of metabolic regulation driven by epigenetic mechanisms, that enables cancer cells to autonomously activate iron metabolism for their survival. Together, these underscore the integration of genetic mutations with metabolic reprogramming and epigenetic shifts in cancer, suggesting a new means to identifying patient subsets suitable for specific precision therapeutics.

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Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer

Cited by 45 publications

References 99 publications

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

The Metabolic Landscape of Lung Cancer: New Insights in a Disturbed Glucose Metabolism

Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review

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