Reciprocal opioid–opioid interactions between the ventral tegmental area and nucleus accumbens regions in mediating μ agonist-induced feeding in rats

Bodnar, Richard J.; Lamonte, Nicole; Israel, Yuriy; Kandov, Yakov; Ackerman, Tsippa F.; Khaimova, Eleonora

doi:10.1016/j.peptides.2004.11.007

Cited by 42 publications

(21 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, NAc shell projects directly to the LH, dorsomedial hypothalamus, ventral tegmental area, nucleus of the solitary tract, and central and basolateral amygdala, as well as to VP (Heimer et al, 1991;Zahm, 2000). Furthermore, eating behavior evoked by NAc-DAMGO can be blocked by simultaneous muscimol inactivation or opioid antagonism in LH, ventral tegmentum, or amygdala (MacDonald et al, 2003;Will et al, 2003;Kim et al, 2004;Will et al, 2004;Bodnar et al, 2005). The LH is especially implicated in food intake , and we noted here that DAMGO infusions in the NAc shell also caused increased Fos expression in LH (besides in VP), whereas naloxone in NAc conversely suppressed spontaneous Fos below normal levels in LH (besides in VP).…”

Section: Discussionmentioning

confidence: 99%

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

Smith¹,

Berridge²

2007

J. Neurosci.

400

307

View full text Add to dashboard Cite

-Opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (NAc) or the ventral pallidum (VP) amplifies hedonic "liking" reactions to sweetness and appetitive "wanting" for food reward. How do these two NAc-VP hotspots interact? To probe their interaction and limbic circuit properties, we assessed whether opioid activation of one hotspot recruited the other hotspot (neurobiologically) and whether opioid hedonic and incentive motivational amplification by either opioid hotspot required permissive opioid coactivation in the other (behaviorally). We found that NAc and VP hotspots reciprocally modulated Fos expression in each other and that the two hotspots were needed together to enhance sucrose "liking" reactions, essentially cooperating within a single hedonic NAc-VP circuit. In contrast, the NAc hotspot dominated for opioid stimulation of eating and food intake ("wanting"), independent of VP activation. This pattern reveals differences between limbic opioid circuits that control reward "liking" and "wanting" functions.

show abstract

Section: Discussionmentioning

confidence: 99%

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

Smith¹,

Berridge²

2007

J. Neurosci.

400

307

View full text Add to dashboard Cite

show abstract

“…An opioid receptor agonist, DALA, does not augment food-related CR responding (e). (Reprinted from Kelley et al 2005b, with permission from Elsevier) Opioid peptide manipulations Infusions of mu receptor or delta receptor, but not kappa receptor, agonists into the striatum increase food intake (Bakshi and Kelley 1993a,b;Bodnar et al 2005;Evans and Vaccarino 1990;Mucha and Iversen 1986;Zhang and Kelley 2000); these effects are seen in widespread areas of the striatum, although there is an anatomical gradient whereby larger effects are obtained with more ventrally placed infusions, including the Acb shell (Bakshi and Kelley 1993b;Zhang and Kelley 2000). Unlike the effects seen with intra-Acb shell GABA receptor stimulation, the hyperphagia associated with mu receptor agonists is influenced by the macronutrient content and taste characteristics of the food; when presented with a concurrent choice between equally preferred carbohydrateor fat-enriched foods, intra-Acb mu receptor stimulation augments fat intake selectively (Zhang et al 1998, see Fig.…”

Section: Interpretations Of the Resistance Of Feeding Consummatory Rementioning

confidence: 99%

Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding

2007

View full text Add to dashboard Cite

show abstract

“…Opioid neurotransmission in the medial shell of the nucleus accumbens is thought to participate in generating hedonic impact for drug rewards and for natural sensory pleasures such as sweetness (Zhang et al, 1998;Peciña and Berridge, 2000;Kelley et al, 2002Kelley et al, , 2004Robbins and Everitt, 2002;Berridge, 2003;Koob, 2003;Bodnar et al, 2005;Kalivas and Volkow, 2005). Opioid shell circuits also contribute to eating behavior and other incentive motivation (Majeed et al, 1986;Mucha and Iversen, 1986;Evans and Vaccarino, 1990;Zhang et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

Peciña¹,

Berridge²

2005

J. Neurosci.

593

493

View full text Add to dashboard Cite

-Opioid systems in the medial shell of the nucleus accumbens contribute to hedonic impact ("liking") for sweetness, food, and drug rewards. But does the entire medial shell generate reward hedonic impact? Or is there a specific localized site for opioid enhancement of hedonic "liking" in the medial shell? And how does enhanced taste hedonic impact relate to opioid-stimulated increases in food intake? Here, we used a functional mapping procedure based on microinjection Fos plumes to localize opioid substrates in the medial shell of the nucleus accumbens that cause enhanced "liking" reactions to sweet pleasure and that stimulate food intake. We mapped changes in affective orofacial reactions of "liking"/"disliking" elicited by sucrose or quinine tastes after D-Ala 2 -N-Me-Phe 4 -Glycol 5-enkephalin (DAMGO) microinjections in rats and compared hedonic increases to food intake stimulated at the same sites. Our maps indicate that opioid-induced increases in sucrose hedonic impact are generated by a localized cubic millimeter site in a rostrodorsal region of the medial shell. In contrast, all regions of the medial shell generated DAMGO-induced robust increases in eating behavior and food intake. Thus, our results identify a locus for opioid amplification of hedonic impact and reveal a distinction between opioid mechanisms of food intake and hedonic impact. Opioid circuits for stimulating food intake are widely distributed, whereas hedonic "liking" circuits are more tightly localized in the rostromedial shell of the nucleus accumbens.

show abstract

Reciprocal opioid–opioid interactions between the ventral tegmental area and nucleus accumbens regions in mediating μ agonist-induced feeding in rats

Cited by 42 publications

References 46 publications

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

Contact Info

Product

Resources

About