Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

Mayberg, Helen S.; Liotti, Mario; Brannan, Stephen K.; McGinnis, Scott; Mahurin, Roderick K.; Jerabek, Paul; Silva, J. Arturo; Tekell, Janet L.; Martin, Charles C.; Lancaster, Jack L.; Fox, Peter T.

doi:10.1176/ajp.156.5.675

Cited by 2,061 publications

(115 citation statements)

References 51 publications

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“…Significant current density (SCD) and significant current scatter (SCS) are measures of subgenual cingulate cortex (SGC) excitability, and DLPFC-SGC effective connectivity, respectively (Hadas et al, 2019 ). Hyperactivity of the SGC and DLPFC-SGC connectivity have repeatedly been implicated in the pathophysiology of MDD (Mayberg et al, 1999 ).…”

Section: Resultsmentioning

confidence: 99%

Resting and TMS-EEG markers of treatment response in major depressive disorder: A systematic review

Strafella

Chen

Rajji

et al. 2022

Front. Hum. Neurosci.

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Electroencephalography (EEG) is a non-invasive method to identify markers of treatment response in major depressive disorder (MDD). In this review, existing literature was assessed to determine how EEG markers change with different modalities of MDD treatments, and to synthesize the breadth of EEG markers used in conjunction with MDD treatments. PubMed and EMBASE were searched from 2000 to 2021 for studies reporting resting EEG (rEEG) and transcranial magnetic stimulation combined with EEG (TMS-EEG) measures in patients undergoing MDD treatments. The search yielded 966 articles, 204 underwent full-text screening, and 51 studies were included for a narrative synthesis of findings along with confidence in the evidence. In rEEG studies, non-linear quantitative algorithms such as theta cordance and theta current density show higher predictive value than traditional linear metrics. Although less abundant, TMS-EEG measures show promise for predictive markers of brain stimulation treatment response. Future focus on TMS-EEG measures may prove fruitful, given its ability to target cortical regions of interest related to MDD.

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Section: Resultsmentioning

confidence: 99%

Resting and TMS-EEG markers of treatment response in major depressive disorder: A systematic review

Strafella

Chen

Rajji

et al. 2022

Front. Hum. Neurosci.

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Section: Discussionmentioning

confidence: 99%

“…The AIns signals risk prediction and risk prediction error (Preuschoff et al, 2008), and suboptimal computation of risk has been shown in substance abusers (Gowin, Mackey, & Paulus, 2013). In addition to the insula, the SCA expressed a negative relationship to alcohol intake over time, the SCA is a critical node underlying emotional regulation (Mayberg et al, 1999; Phan, Wager, Taylor, & Liberzon, 2002) and its significance in predicting AUDIT change highlights its role in negative emotionality theories in addiction (Kwako, Momenan, Litten, Koob, & Goldman, 2016). The dorsal cingulate, a region implicated in substance cue reactivity and craving, also showed a relationship with resilience but was no longer significant after covarying for age and gender, highlighting the importance of demographic variables for prospective alcohol usage.…”

Section: Discussionmentioning

confidence: 99%

The prediction of resilience to alcohol consumption in youths: insular and subcallosal cingulate myeloarchitecture

et al. 2020

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Background The prediction of alcohol consumption in youths and particularly biomarkers of resilience, is critical for early intervention to reduce the risk of subsequent harmful alcohol use. Methods At baseline, the longitudinal relaxation rate (R1), indexing grey matter myelination (i.e. myeloarchitecture), was assessed in 86 adolescents/young adults (mean age = 21.76, range: 15.75–26.67 years). The Alcohol Use Disorder Identification Test (AUDIT) was assessed at baseline, 1- and 2-year follow-ups (12- and 24-months post-baseline). We used a whole brain data-driven approach controlled for age, gender, impulsivity and other substance and behavioural addiction measures, such as problematic cannabis use, drug use-related problems, internet gaming, pornography use, binge eating, and levels of externalization, to predict the change in AUDIT scores from R1. Results Greater baseline bilateral anterior insular and subcallosal cingulate R1 (cluster-corrected family-wise error p < 0.05) predict a lower risk for harmful alcohol use (measured as a reduction in AUDIT scores) at 2-year follow-up. Control analyses show that other grey matter measures (local volume or fractional anisotropy) did not reveal such an association. An atlas-based machine learning approach further confirms the findings. Conclusions The insula is critically involved in predictive coding of autonomic function relevant to subjective alcohol cue/craving states and risky decision-making processes. The subcallosal cingulate is an essential node underlying emotion regulation and involved in negative emotionality addiction theories. Our findings highlight insular and cingulate myeloarchitecture as a potential protective biomarker that predicts resilience to alcohol misuse in youths, providing novel identifiers for early intervention.

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“…MDD is a network disorder involving distributed brain regions connected directly and indirectly by white matter tracts [11, 12, 13]. The subcallosal cingulate cortex (SCC) is a particularly important node in the MDD brain network and has been shown to be metabolically correlated with mood state and antidepressant response[14, 15, 16].…”

Section: Introductionmentioning

confidence: 99%

“…The subcallosal cingulate cortex (SCC) is a particularly important node in the MDD brain network and has been shown to be metabolically correlated with mood state and antidepressant response[14, 15, 16]. This suggests an electrophysiologic correlate, potentially in the oscillatory activity of macroscopically recorded field potentials [15, 11, 17]. Early investigation of these field potentials in intraoperative [18] and post-operative [19] settings have yielded promising biomarkers, but chronic and dense recordings are needed to better capture the characteristic time constants of depression recovery.…”

Section: Introductionmentioning

confidence: 99%

Decoding depression during subcallosal cingulate deep brain stimulation

Tiruvadi

Veerakumar²,

Smart

et al. 2022

Preprint

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Deep brain stimulation of subcallosal cingulate white matter (SCCwm-DBS) alleviates symptoms of treatment resistant depression (TRD) over months of therapy. Readouts of depression symptom severity derived from neural recordings are needed for more systematic study and improvement of the therapy. In this study, we measured local field potentials (LFP) multiple times a day alongside seven months of therapy using the Activa PC+S™ in six patients treated with SCCwm-DBS. We found significant changes in oscillatory power between early and late therapy after accounting for stimulation-related distortions, particularly within the β band. We then used a decoder strategy to identify oscillatory activity that tracked with depression measurements over seven months, with asymmetric δ and β oscillations contributing to a statistically significant prediction of 10% of the measured depression signal. Simulating its use in clinical decision-making, we demonstrated that the DR-SCC yield clinically meaningful information that can augment other measures of depression state. Ultimately, this DR-SCC provides a data-driven first-step towards objectively tracking chronic recovery after antidepressant DBS implantation and developing adaptive DBS strategies in the presence of active stimulation.

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Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

Cited by 2,061 publications

References 51 publications

Resting and TMS-EEG markers of treatment response in major depressive disorder: A systematic review

Resting and TMS-EEG markers of treatment response in major depressive disorder: A systematic review

The prediction of resilience to alcohol consumption in youths: insular and subcallosal cingulate myeloarchitecture

Decoding depression during subcallosal cingulate deep brain stimulation

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