Reciprocal Interactions Between Apelin and Noncoding RNAs in Cancer Progression
Abdollah Jafarzadeh,
Bahar Naseri,
Hossein Khorramdelazad
et al.
Abstract:Apelin, a bioactive peptide that serves as an endogenous ligand for the apelin receptor (APJ), is overexpressed in various types of cancers and contributes to cancer cell proliferation, viability, migration, angiogenesis, and metastasis, as well as immune deviation. Noncoding RNAs (ncRNAs) regulate gene expression, and there is growing evidence suggesting a bidirectional crosstalk between ncRNAs (including long noncoding RNAs [lncRNAs], circular RNAs [circRNAs], and microRNAs [miRNAs]) and apelin in cancers. C… Show more
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