Reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms of<i>Borrelia</i>sp.

Goc, Anna; Niedzwiecki, Aleksandra; Rath, Matthias

doi:10.1111/jam.13523

Cited by 4 publications

(6 citation statements)

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“…Previously we reported that particular phytochemicals such as polyphenols (baicalein, luteolin, and rosmarinic acid), fatty acids (monolaurin, 10-CDA), and iodine express in vitro antibacterial efficacy when applied individually and in dual combinations against the Borrelia spp. that are recognized as causative pathogens of LD in the USA and Europe [32,39]. In the present in vitro study we took another step towards increasing the efficacy and expanding the pleotropic mechanistic effects of these selected compounds against Borrelia spp.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we showed that the combinations of baicalein with luteolin as well as monolaurin with cis-2-decenoic acid displayed synergistic anti-spirochete and additive anti-biofilm effects. Moreover, baicalein and luteolin when combined with rosmarinic acid or iodine produced additive bacteriostatic and bactericidal effects against spirochetes and persisters, respectively [39].…”

Section: Introductionmentioning

confidence: 99%

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Synergistic Anti-Borreliae Efficacy of a Composition of Naturally-occurring Compounds: an In vitro Study

Goc

Niedzwiecki

Rath

2019

JNB

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Background: Borrelia sp, which is a pathogenic agent of Lyme diseases in mammals, has become an increasing problem worldwide due to the emergence of persistence. In this study we investigated whether a defined composition of naturally occurring substances could display a broad and synergistic action in vitro against both active and persistent forms of Borrelia spp.Methods: A formulation of six plant-derived compounds combined at their 1/32-1/2 MIC values was tested in vitro against two species of Borrelia recognized as causative agents of Lyme disease in North America and Europe.Results: The results showed that a composition of baicalein, luteolin, rosmarinic acid, monolaurin, cis-2 decenoic acid, and iodine at their 1/8 MIC values has significant synergistic effect against the active and persisting latent forms. This composition revealed anti-oxidative properties affecting Borrelia’s membrane but not DNA. Finally, we observed its inhibitory effect on the release of IL-1α, IL-1β, and IL-6 by human CD14+ monocytes stimulated with live Borrelia sp.Conclusion: These results suggest that such a formulation of compounds might be considered and further explored for its significant pleotropic anti-Borreliae efficacy. Additional in vivo and human studies are warranted to validate this possibility.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synergistic Anti-Borreliae Efficacy of a Composition of Naturally-occurring Compounds: an In vitro Study

Goc

Niedzwiecki

Rath

2019

JNB

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“…Rosmarinic acid is an active component of the Lamiaceae (Labiatae) family and has been associated with anti-inflammatory and antioxidant activity [ 159 ]. According to Goc and colleagues [ 160 ], the addition of rosmarinic acid in conjunction with either luteolin or baicalein had additive bacteriostatic effects on B. burgdorferi anti-spirochetal activity.…”

Section: Discussionmentioning

confidence: 99%

“…In their 2021 paper, Zhang and colleagues [ 74 ] provided evidence that baicalein showed good in vitro activity against B. duncani , superior to both quinine and clindamycin. Interestingly, Goc and colleagues [ 160 ] have been able to show synergistic outcomes when baicalein was combined with other nutraceuticals, such as luteolin. This combination showed synergistic cooperation in killing knob-/round-shaped persistent forms and additive effects in the eradication of biofilms formed by the Borrelia burgdorferi and B. garinii studied.…”

Section: Discussionmentioning

confidence: 99%

The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses

Shor

Schweig²

2023

Microorganisms

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The primary objective of this paper is to provide an evidence-based update of the literature on the use of bioactive phytochemicals, nutraceuticals, and micronutrients (dietary supplements that provide health benefits beyond their nutritional value) in the management of persistent cases of Borrelia burgdorferi infection (Lyme disease) and two other tick-borne pathogens, Babesia and Bartonella species. Recent studies have advanced our understanding of the pathophysiology and mechanisms of persistent infections. These advances have increasingly enabled clinicians and patients to utilize a wider set of options to manage these frequently disabling conditions. This broader toolkit holds the promise of simultaneously improving treatment outcomes and helping to decrease our reliance on the long-term use of pharmaceutical antimicrobials and antibiotics in the treatment of tick-borne pathogens such as Borrelia burgdorferi, Babesia, and Bartonella.

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“…In recent years, the effects of several phytochemicals on Borrelia have been studied and found to be effective against the different pleomorphic forms of the bacteria [8][9][10][16][17][18]. For instance, Stevia whole leaf extract has been found to reduce the size and number of Borrelia biofilms [10].…”

Section: Discussionmentioning

confidence: 99%

Effective killing of Borrelia burgdorferi in vitro with novel herbal compounds

Karvonen¹,

Gilbert²

2018

Gen Med Open

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Introduction:The tick-borne disease Lyme Borreliosis is caused by Borrelia bacteria. The disease can persist even after treatment with antibiotics, which is why other methods of treatment are needed. Herbal compounds and phytochemicals have been recently examined in relation to eradicating Borrelia bacteria in vitro. Objective:The possible antimicrobial effect of two novel compounds, Biocidin Liquid and LSF Broad-Spectrum Liposomal formulas, was examined in the hopes of discovering an alternative method for eradication of Borrelia bacteria. Methods:The minimum inhibitory concentrations (MICs) and minimum bacterial deaths (MBDs), as well as, time-kill effect of each compound were utilized in the study. Results:The Liquid formula effectively killed the spirochetes with 1:10 dilution, while the MIC for the Liposomal formula was 1:25. Moreover, the MIC for both compounds with Round Bodies was 1:50 and for biofilms 1:10. Though long-term effect (MBD) was seen only with 1:5 dilutions for both formulas. Additionally, the killing effect of each compound was observed already at 10 min post-treatment. Conclusion:The study conducted here provides new insight into the antimicrobial effect of herbal compounds. Furthermore, studies such as these are required in order to discover possible alternatives to antibiotics in the battle against Borrelia infections.

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Reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms ofBorreliasp.

Abstract: Presented here in vitro results might help advancing our knowledge and improving the approach to target Borrelia sp.

Cited by 4 publications

References 71 publications

Synergistic Anti-Borreliae Efficacy of a Composition of Naturally-occurring Compounds: an In vitro Study

Synergistic Anti-Borreliae Efficacy of a Composition of Naturally-occurring Compounds: an In vitro Study

The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses

Effective killing of Borrelia burgdorferi in vitro with novel herbal compounds

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