Reciprocal and Topographic Connections Between the Piriform and Prefrontal Cortices in the Rat: A Tracing Study Using the B Subunit of the Cholera Toxin

Datiche, Frédérique; Cattarelli, Martine

doi:10.1016/s0361-9230(96)00082-2

Cited by 63 publications

(40 citation statements)

References 39 publications

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“…The effective site of action of the scopolamine injection in the PL confirms the importance of this cortical area in ODT. The PL cortex has reciprocal connections to olfactory bulbs (Neafsey et al 1986) and piriform cortex (Datiche and Cattarelli 1996), and it is activated after learning the ODT task (Tronel and Sara 2002). Other studies indicate that NMDA receptors in the PL region are also important in the early stages of ODT memory consolidation, reporting a pattern of results much similar to the present findings.…”

Section: Discussionsupporting

confidence: 88%

Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task

Carballo-Márquez¹,

Vale-Martínez²,

Guillazo-Blanch³

et al. 2007

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The present experiments determined the consequences of blocking muscarinic cholinergic receptors of the prelimbic (PL) cortex in the acquisition and retention of an odor-reward associative task. Rats underwent a training test (five trials) and a 24-h retention test (two retention trials and two relearning trials). In the first experiment, rats were bilaterally infused with scopolamine (20 or 5 µg/site) prior to training. Although scopolamine rats showed acquisition equivalent to PBS-injected controls, they exhibited weakened performance in the 24-h retention test measured by number of errors. In the second experiment, rats were injected with scopolamine (20 µg/site) immediately or 1 h after training and tested 24 h later. Scopolamine rats injected immediately showed severe amnesia detected in two performance measures (errors and latencies), demonstrating deficits in retention and relearning, whereas those injected 1 h later showed good 24-h test performance, similar to controls. These results suggest that muscarinic transmission in the PL cortex is essential for early memory formation, but not for acquisition, of a rapidly learned odor discrimination task. Findings corroborate the role of acetylcholine in consolidation processes and the participation of muscarinic receptors in olfactory associative tasks.

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Section: Discussionsupporting

confidence: 88%

Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task

Carballo-Márquez¹,

Vale-Martínez²,

Guillazo-Blanch³

et al. 2007

Learn. Mem.

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“…A network extended to insular and infralimbic cortices after the distal-proximal experience of the odor The prefrontal cortex, and especially the ILC, receives direct olfactory projections from the piriform cortex (Datiche and Cattarelli, 1996). The blockade of the prefrontal cortex was reported (Fig.…”

Section: An Effective Cs-us Association Duringmentioning

confidence: 91%

The Way an Odor Is Experienced during Aversive Conditioning Determines the Extent of the Network Recruited during Retrieval: A Multisite Electrophysiological Study in Rats

Chapuis¹,

Garcia²,

Messaoudi³

et al. 2009

J. Neurosci.

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Recent findings have revealed the importance of orthonasal and retronasal olfaction in food memory, especially in conditioned odor aversion (COA); however, little is known about the dynamics of the cerebral circuit involved in the recognition of an odor as a toxic food signal and whether the activated network depends on the way (orthonasal vs retronasal) the odor was first experienced. In this study, we mapped the modulations of odor-induced oscillatory activities through COA learning using multisite recordings of local field potentials in behaving rats. During conditioning, orthonasal odor alone or associated with ingested odor was paired with immediate illness. For all animals, COA retrieval was assessed by orthonasal smelling only. Both types of conditioning induced similarly strong COA. Results pointed out (1) a predictive correlation between the emergence of powerful beta (15-40 Hz) activity and the behavioral expression of COA and (2) a differential network distribution of this beta activity according to the way the animals were exposed to the odor during conditioning. Indeed, for both types of conditioning, the aversive behavior was predicted by the emergence of a strong beta oscillatory activity in response to the odor in the olfactory bulb, piriform cortex, orbitofrontal cortex, and basolateral amygdala. This network was selectively extended to the infralimbic and insular cortices when the odor was ingested during acquisition. These differential networks could participate in different food odor memory; these results are discussed in line with recent behavioral results that indicate that COA can be formed over long odor-illness delays only if the odor is ingested.

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“…This infralimbic region of the medial frontal cortex is connected to the PCx (Datiche and Cattarelli 1996) and to the nucleus of the solitary tract. The IL is believed to integrate viscerosensory inputs (Sesack et al 1989).…”

Section: Discussionmentioning

confidence: 99%

“…The IC receives gustatory inputs (Nakashima et al 2000) as well as indirect olfactory inputs via its connections with the PCx (Datiche and Cattarelli 1996). According to Kiefer et al (1982), its lesions disrupted neither the acquisition nor the retention of TPOA.…”

Section: Discussionmentioning

confidence: 99%

“…We further examined the main component of the olfactory cortex, i.e., the piriform cortex (PCx) which is involved in associative olfactory memory (Haberly and Bower 1989;Litaudon et al 1997;Zinyuk et al 2001). The infralimbic cortex (IL) was also analyzed as it is connected to the Hipp and receives olfactory inputs via the PCx (Datiche and Cattarelli 1996). Lastly, we examined the possible involvement of the VLO in TPOA retrieval as it receives both olfactory and gustatory inputs (Rolls 2001).…”

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confidence: 99%

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Fos and Egr1 expression in the rat brain in response to olfactory cue after taste-potentiated odor aversion retrieval

Dardou¹,

Datiche²,

Cattarelli³

2006

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When an odor is paired with a delayed illness, rats acquire a relatively weak odor aversion. In contrast, rats develop a strong aversion to an olfactory cue paired with delayed illness if it is presented simultaneously with a gustatory cue. Such a conditioning effect has been referred to as taste-potentiated odor aversion learning (TPOA). TPOA is an interesting model for studying neural mechanisms of plasticity because of its robustness and rapid acquisition. However, the neural substrate involved in TPOA retrieval has not been well characterized. To address this question, we used immunocytochemical detection of inducible transcription factors encoded by the immediate-early genes Fos and Egr1. Thirsty male rats were conditioned to TPOA learning, and they were submitted to retrieval in the presence of the learned odor 3 d later. Significant increases in both Fos and Egr1 expressions were observed in basolateral amygdala, insular cortex, and hippocampus in aversive rats in comparison with the all the control groups. The pattern of neuronal activity seemed unlikely to be related to the sole LiCl injection. Lastly, opposite patterns of Fos and Egr1 were noted in the entorhinal cortex and the central nucleus of amygdala, suggesting a differential involvement of these markers in retrieval of TPOA.Odors are critical cues for rodents since odors give the rodents information about their environment. Odors allow the rodents to escape from predators, to find food, or to avoid consumption of toxic products. Memorization of such information is crucial for animal survival. Moreover, olfactory learning permits a previously neutral cue to acquire significance after having been paired with a biologically relevant reinforcement. Rats can acquire weak aversion when an odor is paired with delayed-illness (Bernstein 1991). In contrast, when an odor is simultaneously presented with a taste cue, rats can develop strong aversion to the odor cue. Such a conditioning has been referred to as tastepotentiated odor aversion (TPOA) learning (Palmerino et al. 1980). Thus, taste-mediated potentiation allows odor to gain associative strength and the animals to avoid consumption of poisonous substance on the basis of its odor only (Bernstein 1991). TPOA learning is an attractive model for studying odor memory because of its robustness, rapid acquisition, and adaptive feature (Welzl et al. 2001).Most of the data regarding the brain areas that could mediate TPOA learning are provided by either lesion or pharmalogical experiments. Various brains areas involved in olfactory, gustatory, and visceral pain processing could play a role in TPOA learning. Several studies (Bermùdez-Rattoni et al. 1986;Hatfield et al. 1992;Ferry et al. 1995) indicate that the basolateral nucleus of amygdala (BLA) could play a major role in the acquisition but not in the retrieval of TPOA. In addition, the BLA is known for its involvement in learning the biological significance of events and could modulate memory storage of emotional events (McGaugh 2002). In contrast, the l...

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Reciprocal and Topographic Connections Between the Piriform and Prefrontal Cortices in the Rat: A Tracing Study Using the B Subunit of the Cholera Toxin

Cited by 63 publications

References 39 publications

Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task

Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task

The Way an Odor Is Experienced during Aversive Conditioning Determines the Extent of the Network Recruited during Retrieval: A Multisite Electrophysiological Study in Rats

Fos and Egr1 expression in the rat brain in response to olfactory cue after taste-potentiated odor aversion retrieval

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