Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome

Güdücü, Nilgün; Görmüş, Uzay; Alp, Esra; Kavak, Zehra Neşe; Dünder, İlkkan

doi:10.1177/1721727x1401200115

Cited by 3 publications

(5 citation statements)

References 29 publications

(28 reference statements)

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“…The remaining 25 studies failed to demonstrate any statistically significant difference in serum CRP levels between PCOS women and healthy controls. Of these, seven studies reported statistically significant increase in other inflammatory markers as described below [ 49 , 50 , 59 , 67 , 69 , 85 , 86 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition to the increased inflammatory markers, our review has found reduced adiponectin, which is a well-known anti-inflammatory factor, in PCOS women. Some studies have also reported a decrease in Pentraxin -3 (PTX3) [ 30 , 86 ], which is structurally related to CRP and plays a regulatory role in inflammation with a possible protective effect against atherosclerosis and cardiovascular risks [ 127 ]. All these findings indicate that the ongoing inflammation in PCOS is a double-sided process with increased proinflammatory factors as well as reduced inflammatory protective factors.…”

Section: Discussionmentioning

confidence: 99%

“…Covington, 2014 [85] ** Guducu, 2014 [86] **** Acknowledgments: The research team are very grateful to the all the librarians and staff in library of University Hospitals of Derby and Burton NHS Foundation Trust for their immense help in database search and obtaining full text of selected articles. We are also grateful to the Egyptian Cultural Center and Education bureau in London for their funding.…”

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confidence: 99%

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The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl

James

Seyam

et al. 2021

IJMS

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Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the inflammatory status in PCOS women and to determine whether it is related to PCOS or to its associated adiposity. We searched electronic databases including PUBMED, EMBASE and MEDLINE, SCOPUS, DynaMed plus, TRIP, ScienceDirect and Cochrane Library, for studies investigating C-reactive protein (CRP) and other inflammatory makers in PCOS women versus healthy controls. Quality and risk of bias for selected studies were assessed using the modified Newcastle–Ottawa scale. CRP data were extracted and pooled using RevMan for calculation of the standardized mean difference (SMD) and 95% confidence interval (CI). Eighty-five eligible studies were included in the systematic review, of which 63 were included in the meta-analysis. Pooled analysis of the 63 studies revealed significantly higher circulating CRP in PCOS women (n = 4086) versus controls (n = 3120) (SMD 1.26, 95%CI, 0.99, 1.53). Sensitivity meta-analysis of 35 high quality studies including non-obese women showed significantly higher circulating CRP in PCOS women versus controls (SMD 1.80, 95%CI, 1.36, 2.25). In conclusion, circulating CRP is moderately elevated in PCOS women independent of obesity, which is indicative of low-grade chronic inflammation.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl

James

Seyam

et al. 2021

IJMS

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“…The follicular PTX3 level among non-obese women was significantly higher in PCOS subjects and associated with the existence of PCOS and ovarian hyperandrogenism [18]. However, circulating PTX3 in PCOS women was previously reported as elevated [22,23], diminished [24,25], or similar [32] to non-PCOS subjects. Recently, researchers from Helsinki found that circulating PTX3 levels during in vitro fertilization could provide benefits in risk assessment for ovarian hyperstimulation syndrome [33].…”

Section: Discussionmentioning

confidence: 89%

Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study

Jin¹,

Zou²,

Yang³

et al. 2021

BMC Endocr Disord

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Background Pentraxin 3 (PTX3) - a crucial humoral innate immunity component – is related to obesity and cardiovascular complications in women who suffer from polycystic ovary syndrome (PCOS). However, the circulating PTX3 level in PCOS is still debated. In this study, we aimed to evaluate PTX3 plasma levels in PCOS women of childbearing age, and find possible endocrine/metabolic factors that could affect this level. Methods A total of 360 women were enrolled: 120 PCOS women and 240 body mass index (BMI) matched normally ovulating women. Blood samples were collected on the third day of natural menstrual cycle or from the bleeding after progesterone withdrawal. The PTX3 concentration was measured by immunoassay. Results The PTX3 plasma level was significantly higher in PCOS women compared to controls. There was a positive correlation between PTX3 plasma level and PCOS diagnosis, overweight, cycle length, serum LH to FSH ratio, estradiol, total testosterone (TT) on the third day of menstrual cycle, antral follicle count (AFC), as well as uric acid. Multivariant linear regression analysis indicated that participants’ serum PTX3 levels were proportional to the circulating TT level, existence of PCOS, basal estradiol level and AFC. Conclusions Overall, the circulating PTX3 level was elevated in PCOS women and significantly associated with the presence of hyperandrogenism. This study provided the basis for further in-depth researches regarding PTX3 role in PCOS pathophysiology.

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“…Up to now, there were several studies investigating serum PTX3 level in PCOS, but the association between PTX3 and PCOS remains uncertain. Among these studies, serum PTX3 level in PCOS women was found to be lower [ 12 , 13 ], higher [ 14 , 17 ], or comparable [ 18 ] to that of non-PCOS women. In contrast to the short pentraxin, CRP, which is predominantly produced in the liver, PTX3 is synthesized in response to local inflammatory stimuli by a variety of cells, and ovarian follicular cells have innate immune capabilities that modulate their endocrine function [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated ovarian pentraxin 3 in polycystic ovary syndrome

Pan

Zhou

et al. 2021

J Assist Reprod Genet

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Purpose Pentraxin 3 (PTX3) plays a crucial role in cumulus expansion and fertilization. The ovarian PTX3 level in polycystic ovary syndrome (PCOS) remains uncertain. In the present study, we investigated the follicular PTX3 levels and found the influence of reproductive hormones on ovarian PTX3 concentration. Methods This study was based on 204 healthy-weight women (102 PCOS and 102 normal ovulating subjects) undergoing in vitro fertilization (IVF). Follicular fluid (FF) was collected during oocyte retrieval. The PTX3 levels and other hormone levels in FF samples were analyzed by enzyme-linked immunosorbent assay (ELISA). Results The PTX3 level in the follicle was significantly higher in the healthy-weight PCOS women than controls. Positive correlations were found between ovarian PTX3 level and the existence of PCOS, cycle length, basal LH to FSH ratio and TT in serum, antral follicle count, and ovarian insulin and androgen level, and inverse correlations with the basal serum PRL and ovarian SHBG. In multivariant linear regression analysis, the presence of PCOS diagnosis, participants’ basal LH to FSH ratio, and ovarian androstenedione level were the main predictors of ovarian PTX3 level among the enrolled subjects. Conclusion Elevated ovarian PTX3 level supports the low-grade chronic inflammatory state in the follicles of PCOS. The existence of PCOS, disturbed pituitary gland, and ovarian hyperandrogenism might also be related to this state of low-grade chronic inflammation and could be a subject of further study.

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Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome

Cited by 3 publications

References 29 publications

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study

Elevated ovarian pentraxin 3 in polycystic ovary syndrome

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