Recipient seropositivity for adenovirus type 11 (AdV11) is a highly predictive factor for the development of AdV11-induced hemorrhagic cystitis after allogeneic hematopoietic SCT

Nakazawa, Yozo; Saito, Shoji; Yanagisawa, Ryu; Suzuki, Tetsuro; Ito, Toshiro; Ishida, Fumihiro; Muramatsu, Hideki; Matsumoto, Kenji; Kato, Kentaro; Ishida, Hiroyuki; Umeda, Katsutsugu; Adachi, Souichi; Nakahata, Tatsutoshi; Koike, Kenichi

doi:10.1038/bmt.2012.206

Cited by 9 publications

(7 citation statements)

References 8 publications

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“…Patients with grade ≥2 hematuria that were found to be BKV‐positive by PCR tests were diagnosed with BKV‐HC 12,22 . In Japan, adenovirus‐associated HC is more common than in other countries, and a significant association between adenovirus and HC was previously demonstrated 23,24 . Therefore, when other cystitis‐associated viruses, such as adenovirus, were detected together with BKV in a patient's urine sample, the patient was not diagnosed with BKV‐HC.…”

Section: Methodsmentioning

confidence: 99%

“…12,22 In Japan, adenovirus-associated HC is more common than in other countries, and a significant association between adenovirus and HC was previously demonstrated. 23,24 Therefore, when other cystitis-associated viruses, such as adenovirus, were detected together with BKV in a patient's urine sample, the patient was not diagnosed with BKV-HC. The viral load of BKV in plasma was measured by BML, INC.…”

Section: Definition Diagnosis and Treatment Of Bkv-hcmentioning

confidence: 99%

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A cluster of BK polyomavirus‐associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

Hosoi

Murata

Suzuki

et al. 2021

Transplant Infectious Dis

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Background BK polyomavirus (BKV) can cause hemorrhagic cystitis (HC) in immunocompromised patients after hematopoietic stem cell transplantation (HSCT). It remains unclear whether nosocomial BKV infections occur. During a 9‐month period, an increase in BKV‐associated HC (BKV‐HC) cases was observed at our institution. Aim The BKV‐HC cluster population was compared with populations of HSCT patients from before and after the BKV‐HC cluster to evaluate whether nosocomial BKV transmission had occurred. Methods A retrospective analysis was carried out to assess the risk of patients developing BKV‐HC after HSCT. The background data of the cluster patients were compared with those of the patients who underwent HSCT before or after the cluster, and the collected BKV isolates were serotyped. Results BKV‐HC involving grade ≥2 hematuria occurred in six of 15 HSCT recipients during a 9‐month period. The incidence of BKV‐HC was significantly higher in this period than in the other periods (p = 0.0014). There were no significant differences in the patients’ background data between the cluster and non‐cluster periods, including in terms of risk factors for BKV‐HC. Serotype analyses of BKV revealed that the BKV detected in the urine samples from four of the six BKV‐HC patients belonged to subtype Ic. The gene sequences of these four BKV exhibited >99.5% homology. Conclusion Our study suggests that nosocomial BKV infections may occur after HSCT. Although many cases of BKV‐HC are caused by the reactivation of a latent virus, it is necessary to employ appropriate hygiene measures when cases of BKV‐HC occur.

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Section: Methodsmentioning

confidence: 99%

Section: Definition Diagnosis and Treatment Of Bkv-hcmentioning

confidence: 99%

A cluster of BK polyomavirus‐associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

Hosoi

Murata

Suzuki

et al. 2021

Transplant Infectious Dis

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“…DNA was extracted from 200 μL of the acellular fraction of the patient’s urine or whole blood. Real‐time PCR was performed to quantify the AdV load, as previously reported …”

Section: Methodsmentioning

confidence: 99%

“…AdV‐associated HC is one of the major complications following allogeneic HSCT especially in Japan, because of a high frequency of recipient seropositivity for AdV11 . Although preemptive treatment with cidofovir has demonstrated efficacy in patients with AdV11‐HC shortly after HSCT, cidofovir frequently causes severe nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Successful induction of therapeutic urinary concentration by intravenous ganciclovir and oral valganciclovir with remission of adenoviral hemorrhagic cystitis after cord blood transplantation

Yanagisawa

Saito

Katsuyama

et al. 2018

Pediatric Transplantation

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AdV11-HC is one of the major complications after allogeneic HSCT in Japan. We previously reported that the intravenous infusion of ganciclovir was effective against AdV11-HC in a post-transplant patient. We here report a case of a 10-year-old boy who underwent cord blood transplantation for the treatment of relapsed lymphoblastic lymphoma. He developed AdV11-HC with an elevated AdV load in his urine and blood on day 14 after HSCT. He was immediately treated with intravenous ganciclovir; he rapidly achieved a remission of AdV11-HC with a decreased AdV load in his urine and blood. He remained in remission of AdV11-HC, even after we switched ganciclovir to oral valganciclovir on day 63. A pharmacokinetics study of his urine revealed that therapeutic concentrations of ganciclovir could be achieved by both intravenous ganciclovir and oral valganciclovir. These findings suggested that both intravenous ganciclovir and oral valganciclovir could be promising alternatives for the treatment of AdV11-HC in post-transplant patients.

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“…Hemorrhagic cystitis (HC) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). HC occurs in 8.6-24% of allo-HSCT recipients and severely impairs their quality of life [1][2][3][4][5][6]. Early-onset HC, which occurs within 1 week after HSCT, mostly develops due to the regimen-related toxicity, while late-onset HC after engraftment is usually caused by viruses, such as human polyomavirus BK (BKV), polyomavirus JC, adenovirus (ADV), and cytomegalovirus (CMV).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of hyperbaric oxygen therapy for virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

et al. 2021

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Although some studies have suggested the effectiveness of hyperbaric oxygen (HBO) therapy for hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT), the role of HBO has not been established. We compared the treatment outcomes of 8 patients with viral HC (adenovirus [ADV], n = 2; BK virus [BKV], n = 6) treated with HBO (HBO[+]) and 8 patients (ADV, n = 2; BKV, n = 6) treated with conventional therapy (HBO[−]), such as urinary catheterization and intravenous cidofovir. HBO therapy was performed at 2.1 atmospheres for 90 min/day until clinical improvement was achieved. The median number of HBO treatments was 10 (range 8-12). The median duration of HBO treatment was 19.5 days (range 10-23 days). All 8 HBO(+) patients achieved complete remission (CR) at a median of 14.5 days (range 5-25 days). Of the 8 HBO(−) patients, 5 (62.5%) obtained CR and 3 remained symptomatic for 2-6 months. The cumulative incidence of transplant-related mortality at day 100 after allogeneic HSCT was significantly higher in the HBO(−) patients than in the HBO(+) patients (14.2 vs. 0%, P < 0.05). No severe HBO-related adverse effects were observed. In conclusion, HBO is a feasible option for treating viral HC after allogeneic HSCT.

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Recipient seropositivity for adenovirus type 11 (AdV11) is a highly predictive factor for the development of AdV11-induced hemorrhagic cystitis after allogeneic hematopoietic SCT

Cited by 9 publications

References 8 publications

A cluster of BK polyomavirus‐associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

A cluster of BK polyomavirus‐associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

Successful induction of therapeutic urinary concentration by intravenous ganciclovir and oral valganciclovir with remission of adenoviral hemorrhagic cystitis after cord blood transplantation

Effectiveness of hyperbaric oxygen therapy for virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

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