Recipient-Derived Hepatocytes in Sex-Mismatched Liver Allografts after Liver Transplantation: Early versus Late Transplant Biopsies

Abstract

Some hepatocytes of sex-mismatched liver grafts were replaced by "recipient-derived cells" during injury. Such repopulation is more common in the early liver-graft biopsies. The severity of acute cellular rejection appears to have no effect on the rate of recipient-derived repopulation.

Effect of recipient-derived cells on the progression of familial amyloidotic polyneuropathy after liver transplantation: a retrospective study

“…Although FISH analysis was performed in only one FAP patient, the presence of recipient-derived cells was also confirmed with almost the equal frequency of previous reports in other diseases. 21,22 However, despite the presence of recipient-derived cells, our results showed that ATTR mRNA was not expressed in the transplanted liver and serum ATTR could not be detected. Previous studies reported that hepatocyte transdifferentiation from recipient bone marrow stem cells was rare, 27 -30 suggesting that the recipient-derived cells in the transplanted liver may be too immature to synthesize TTR.…”

Therapeutic Potential of Adult Bone Marrow Stem Cells in Liver Disease and Delivery Approaches

“…Observations from the human liver allotransplantation indicate that cells of recipient origin can replace biliary epithelial cells, endothelial cells, and hepatocytes, this is consistent with the concept that circulating pluripotent progenitor cells exist and are capable of differentiating into endothelial cells, epithelial cells, and hepatocytes [110][111][112][113]. In bone marrow allotransplantation for haematological malignancy, the bone marrow was from hepatitis B immune donors, it was shown that chronic hepatitis B infection in recipients was eradicated through the adoptive transfer of hepatitis B core antigen reactive CD4+ T cell subsets [114].…”

Chimeric Allografts Induced by Short‐Term Treatment With Stem Cell Mobilizing Agents Result in Long‐Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine

“…Our researchers previously demonstrated that a Lewis-to-DA rat liver graft becomes a host-donor chimera via recipient stem cell repopulation and is accepted without immunosuppression (18). This repopulation process has been reported to occur to a meager extent after the transplantation of a variety of organ types in humans (19)(20)(21)(22)(23)(24) but is inefficient, perhaps due to the provision of conventional immunosuppression, which acts to eliminate donor-recipient interactions and retards liver regeneration in animals (18). Recently, Fan et al confirmed these findings.…”