Recidivous acute urticaria caused by <i>Anisakis simplex</i>

Montoro, A.; Perteguer, María Jesús; Chivato, T.; Laguna, R.; Cuéllar, C.

doi:10.1111/j.1398-9995.1997.tb02418.x

Cited by 74 publications

(67 citation statements)

References 13 publications

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“…When raw or undercooked seafoods with the third-stage larvae of A. simplex are ingested, the parasites occasionally penetrate a gastroduodenal mucosa, causing a disease known as anisakiasis (Sakanari and Mckerrow 1989). Although clinical manifestations of anisakiasis are nausea, vomiting, and diarrhea, allergic reactions mediated by immunoglobulin E (IgE) antibodies, such as urticaria, angioedema, and anaphylaxis, are also induced in individuals previously sensitized by A. simplex (Audicana et al 1995;Del Pozo et al 1997;Fernández de Corres et al 1996;Montoro et al 1997;Moreno-Ancillo et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning and expression of two new allergens from Anisakis simplex

et al. 2006

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The nematode Anisakis simplex is a marine parasite that causes allergy as well as anisakiasis. Although five Anisakis allergens have already been identified, immunoblotting studies suggested that unidentified allergens still exist. In this study, an expression cDNA library constructed from A. simplex was subjected to immunoscreening using an Anisakis-allergic patient serum, and two positive clones coding for allergens (named Ani s 5 and 6) were obtained. Ani s 5 (152 amino acid residues) is homologous with nematode proteins belonging to the SXP/RAL-2 protein family and Ani s 6 (84 amino acid residues) with serine protease inhibitors from various animals. Of the 28 patient sera examined, seven and five reacted to recombinant Ani s 5 and 6 expressed in Escherichia coli, respectively. By inhibition immunoblotting experiments using the recombinant allergens as inhibitors, natural Ani s 5 could be identified as a 15-kDa protein in the crude extract of A. simplex but natural Ani s 6 could not be identified probably due to its low expression. In conclusion, Ani s 5 and 6 are new allergens of A. simplex that are specific to some Anisakis-allergic patients.

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Section: Introductionmentioning

confidence: 99%

Molecular cloning and expression of two new allergens from Anisakis simplex

et al. 2006

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“…Furthermore, HLA DRB1*1502, DQB1*0601, and DRB I *0404 are significantly overrepresented (and hence probable genetic risk factors) in subjects allergic to A. simplex (239). The newly characterized allergens Ani s 2 and Ani s 3 ( (190,192) are showing that allergy in Europe is not confined to the Basque Country but is also in Japan, where more cases have also been diagnosed (152). However, Italian and Portuguese cases are similar to those of the Basque Country because they involve true allergy with cooked fish, and reports from other parts of Spain (Madrid and its surrounding provinces) appear to describe gastroallergic cases caused by raw or undercooked fish (71,99).…”

Section: Human Susceptibility Factorsmentioning

confidence: 99%

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

2008

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SUMMARY Infection of humans with the nematode worm parasite Anisakis simplex was first described in the 1960s in association with the consumption of raw or undercooked fish. During the 1990s it was realized that even the ingestion of dead worms in food fish can cause severe hypersensitivity reactions, that these may be more prevalent than infection itself, and that this outcome could be associated with food preparations previously considered safe. Not only may allergic symptoms arise from infection by the parasites (“gastroallergic anisakiasis”), but true anaphylactic reactions can also occur following exposure to allergens from dead worms by food-borne, airborne, or skin contact routes. This review discusses A. simplex pathogenesis in humans, covering immune hypersensitivity reactions both in the context of a living infection and in terms of exposure to its allergens by other routes. Over the last 20 years, several studies have concentrated on A. simplex antigen characterization and innate as well as adaptive immune response to this parasite. Molecular characterization of Anisakis allergens and isolation of their encoding cDNAs is now an active field of research that should provide improved diagnostic tools in addition to tools with which to enhance our understanding of pathogenesis and controversial aspects of A. simplex allergy. We also discuss the potential relevance of parasite products such as allergens, proteinases, and proteinase inhibitors and the activation of basophils, eosinophils, and mast cells in the induction of A. simplex-related immune hypersensitivity states induced by exposure to the parasite, dead or alive.

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“…A resposta imunológica é desencadeada pelo potencial antigênico das partículas parasitárias, existentes no pescado mesmo após a cocção. Esse dado é comprovado no caso de Anisakis simplex (Fernandez de Corres et al, 1996;Montoro et al 1997 Baylis, 1920. Arq.…”

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