Recherches dans la série de l'acide undécylénique et de ses homologues (II)

Chuit, P.; Boelsing, F.; Hausser, Jack W.; Malet, G.

doi:10.1002/hlca.19270100116

Cited by 17 publications

(2 citation statements)

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“…The smooth reaction of 5m with tetrabromomethane in the presence of triphenylphosphine22 led, in quantitative yield, to the bromo derivative 6m. 23 The latter is the key intermediate in the synthesis of both the sulfonate 3m24 and the Bunte salt 4m.25•26 Representatives of the second group are polyanions derived from monomers 7m, 8m, and 10m. They all have in common an ester function within the chain together with a terminal carboxylate moiety.…”

Section: Chemistrymentioning

confidence: 99%

Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 1. Polymerized Anionic Surfactants

Leydet¹,

Barthélémy²,

Boyer³

et al. 1995

J. Med. Chem.

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A series of polyanionic compounds was synthesized and evaluated for their activity against human immunodeficiency virus (HIV-1, HIV-2) and various other RNA and DNA viruses. Several compounds, i.e., 2p, 3p, 8p, 13p, 14p, 15p, 17p, 18p, and 19p, proved active against HIV-1 within the concentration range of 0.1-3 micrograms/mL while not being toxic to the host cells (CEM, MT-4) at concentrations up to 100 micrograms/mL or higher. As a rule, these polyanionic compounds proved also active, albeit at somewhat higher concentrations than those required for HIV-1 inhibition, against a number of other enveloped viruses, including HIV-2, human cytomegalovirus, influenza A virus, respiratory syncytial virus, and arenaviruses (Junin and Tacaribe). Among the most potent HIV-1 inhibitors ranked compounds 18p and 19p, the sodium salts of N-methylamides obtained by polymerization of monomers prepared starting from 10-undecenoyl chloride and omega-aminoalkanoic acids.

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Section: Chemistrymentioning

confidence: 99%

Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 1. Polymerized Anionic Surfactants

Leydet¹,

Barthélémy²,

Boyer³

et al. 1995

J. Med. Chem.

View full text Add to dashboard Cite

show abstract

“…(5-8) (method I) and alkynols [14][15][16][17][18][19][20][21][22][23][24][25][26] by previously reported solution methods (9) (method II). In method I, polymer-bound diol monomesylates (1, = 4,6,8,9) [®-Trrepresents a 2% divinylbenzene-styrene copolymer containing trityl groups] react with 1-lithioalkynes (2, m = 0-4, 6) [or with lithioacetylide and alkyl halide treatment in a two-step reaction (7)] to give the polymer-bound alkynes (3, m = 0-4, 6; n -4, 6, 8, 9).…”

mentioning

confidence: 99%