Recherches à conseiller pour l'application de la stérilisation ionisante des médicaments

Tilquin, Bernard; Rollmann, Bruno

doi:10.1051/jcp/1996930224

Cited by 20 publications

(7 citation statements)

References 0 publications

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“…When the magnetic field is along the a axis, the NCH 2Ċ H radical indicates only that the unpaired electron is interacted with nitrogen nucleus. The hyperfine coupling constant for the 14 The characterization of the radical is found by comparing the simulated and experimental spectra, and by addition of the derived hyperfine splittings with those obtained in similar radicals (17,19,20). The experimental and simulated EPR spectra were found to be in agreement well with each other, as shown in Figure 1(a) and 1(b).…”

Section: Resultssupporting

confidence: 56%

“…Thus, the radiation-induced free radical formation of EPR dosimetry purposes and the simple amino acids in solid state has been the subject of numerous investigations by EPR (1)(2)(3)(4)(5)(6)(7)(8)(9). Ionizing radiation, x, γ rays and electron beams have been extensively used for a long time in order to sterilize medical devices to improve hygienic quality of food and cosmetics (10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Electron paramagnetic resonance study of free radicals in γ-irradiated L-glutamine and L-glutamine-t-butyl ester hydrochloride

Dicle

Osmanğolu

İpek

2015

Radiation Effects and Defects in Solids

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Electron paramagnetic resonance (EPR) spectra of γ -irradiated single crystals of l-glutamine (LG) and l-glutamine-t-butyl ester hydrochloride (LGBESHCI) powders were studied and analyzed for different orientations of the crystals in the magnetic field, after γ -irradiation. The spectra were observed to be independent of temperature down to 130 K. The hyperfine interaction tensors for one α proton and two β protons of radical have been determined at 295 K. An analysis of the EPR of γ -irradiated single crystals of LG and LGBESHCI powders shows that the paramagnetic species produced by the radiation damage is CH 2Ċ H. The g values of the radical and the hyperfine structure constants of the free electron with nearby protons and 14 N nucleus were determined. The results were found to be in good agreement with the existing literature data.

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Section: Resultssupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Electron paramagnetic resonance study of free radicals in γ-irradiated L-glutamine and L-glutamine-t-butyl ester hydrochloride

Dicle

Osmanğolu

İpek

2015

Radiation Effects and Defects in Solids

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“…Use of ionizing radiation in sterilization of medicinal products, such as catheters, syringes, drug and drug raw materials, is a new technology alternative to heat and gas exposure sterilization (Jacobs, 1995;Reid, 1995;Tilquin and Rollmann, 1996;Boess and Bỏgl, 1996). The advantages of sterilization by irradiation include high penetrating power, low measurable residues, small temperature rise and the fact that there are fewer variables to control (Fauconnet et al, 1996;Basly et al, 1997).…”

Section: Drugs and Medical Products Irradiationmentioning

confidence: 99%

Ionizing Radiation Induced Radicals

Maghraby¹

2012

Current Topics in Ionizing Radiation Research

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“…Gamma radiation processing is a well-proven technique for achieving safe and effective sterilization of disposable medical devices and other medicinal products and also for improvement of the hygienic quality of foods [1][2][3][4][5][6][7]. Its major advantage is due to its high penetrating power and the very small temperature rise induced.…”

Section: Introductionmentioning

confidence: 99%