Recherche de fusions des gènes NTRK : guide pratique pour les pathologistes

NTRK‐rearranged spindle cell neoplasms are ubiquitous tumours of myofibroblastic lineage with a distinct methylation class

“…NTRK1/2/3 gene fusions are involved in a wide variety of tumour types in different organs. 1 There is a striking diversity in soft tissue, as NTRK fusions have been reported in inflammatory myofibroblastic tumours (IMT), 2 infantile fibrosarcomas (IFS) 3 and the ‘spindle cell neoplasm with NTRK fusion’ (SCN–NTRK). 4 This provisional category, included in the 2020 World Health Organisation (WHO) Classification of Soft Tissue Tumours, is associated with a wide morphological spectrum [IFS, IMT, lipofibromatosis‐like neural tumour and malignant peripheral nerve sheath tumour (MPNST)].…”