Receptors | Neurotrophin Receptor Signaling

Kraemer, Bradley R.; Carter, Bruce D.

doi:10.1016/b978-0-12-819460-7.00310-8

Cited by 2 publications

(1 citation statement)

References 202 publications

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“…Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates diverse neural functions, including neurite growth, synaptic plasticity, neuronal differentiation, and cell survival ( 24 ). BDNF performs these functions through interactions with two different receptors.…”

Section: Brain-derived Neurotrophic Factormentioning

confidence: 99%

The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis

Kraemer,

Kraemer

2023

Front. Endocrinol.

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Over the last decade, a considerable amount of new data have revealed the beneficial effects of exercise on hippocampal neurogenesis and the maintenance or improvement of cognitive function. Investigations with animal models, as well as human studies, have yielded novel understanding of the mechanisms through which endocrine signaling can stimulate neurogenesis, as well as the effects of exercise on acute and/or chronic levels of these circulating hormones. Considering the effects of aging on the decline of specific endocrine factors that affect brain health, insights in this area of research are particularly important. In this review, we discuss how different forms of exercise influence the peripheral production of specific endocrine factors, with particular emphasis on brain-derived neurotrophic factor, growth hormone, insulin-like growth factor-1, ghrelin, estrogen, testosterone, irisin, vascular endothelial growth factor, erythropoietin, and cortisol. We also describe mechanisms through which these endocrine responses to exercise induce cellular changes that increase hippocampal neurogenesis and improve cognitive function.

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Section: Brain-derived Neurotrophic Factormentioning

confidence: 99%

The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis

Kraemer,

Kraemer

2023

Front. Endocrinol.

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LM11a-31 Inhibits p75 Neurotrophin Receptor (p75^NTR) Cleavage and is Neuroprotective in a Cell Culture Model of Parkinson’s Disease

Pokharel,

Newchurch,

Overby

et al. 2024

Preprint

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The p75 Neurotrophin Receptor (p75NTR) is a multifunctional transmembrane protein that mediates neuronal responses to pathological conditions in specific regions of the nervous system. In many biological contexts, p75NTRsignaling is initiated through sequential cleavage of the receptor by α- and γ-secretases, which releases receptor fragments for downstream signaling. Our previous work demonstrated that proteolytic processing of p75NTRin this manner is stimulated by oxidative stress in Lund Human Mesencephalic (LUHMES) cells, a dopaminergic neuronal cell line derived from human mesencephalic tissue. Considering the vulnerability of dopaminergic neurons in the ventral mesencephalon to oxidative stress and neurodegeneration associated with Parkinson's disease (PD), we investigated the role of this signaling cascade in neurodegeneration and explored cellular processes that govern oxidative stress-induced p75NTRsignaling. In the present study, we provide evidence that oxidative stress induces cleavage of p75NTRby promoting c-Jun N-terminal Kinase (JNK)-dependent internalization of p75NTRfrom the cell surface. This activation of p75NTRsignaling is counteracted by tropomyosin-related kinase (Trk) receptor signaling; however, oxidative stress leads to Trk receptor downregulation, thereby enhancing p75NTRprocessing. Importantly, we demonstrate that this pathway can be inhibited by LM11a-31, a small molecule modulator of p75NTR, thereby conferring protection against neurodegeneration. Treatment with LM11a-31 significantly reduced p75NTRcleavage and neuronal death associated with oxidative stress. These findings reveal novel mechanisms underlying activation of p75NTRin response to oxidative stress, underscore a key role for p75NTRin dopaminergic neurodegeneration, and highlight p75NTRas a potential therapeutic target for reducing neurodegeneration in PD.

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Receptors | Neurotrophin Receptor Signaling

Cited by 2 publications

References 202 publications

The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis

The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis

LM11a-31 Inhibits p75 Neurotrophin Receptor (p75^NTR) Cleavage and is Neuroprotective in a Cell Culture Model of Parkinson’s Disease

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Receptors | Neurotrophin Receptor Signaling

Cited by 2 publications

References 202 publications

The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis

The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis

LM11a-31 Inhibits p75 Neurotrophin Receptor (p75NTR) Cleavage and is Neuroprotective in a Cell Culture Model of Parkinson’s Disease

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LM11a-31 Inhibits p75 Neurotrophin Receptor (p75^NTR) Cleavage and is Neuroprotective in a Cell Culture Model of Parkinson’s Disease