Receptors for Glucocorticoids in the Human Inner Ear

Rarey, Kyle E.; Curtis, Lisa M.

doi:10.1016/s0194-5998(96)70133-x

Cited by 123 publications

(84 citation statements)

References 17 publications

(20 reference statements)

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“…An alternative theory suggests tinnitus is related to psychological disorders through a cortisol mediator. Existence of glucocorticoid receptors in the inner ear has been proven, coupled with evidence that tinnitus patients have high cortisol levels 30,31 . Correspondingly, patients with anxiety and depression also exhibit higher levels of cortisol, leading to the possibility of a positive feedback loop exacerbating tinnitus 32 .…”

Section: Resultsmentioning

confidence: 99%

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Ziai¹,

Moshtaghi²,

Mahboubi³

et al. 2017

The International Tinnitus Journal

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Objectives: To review literature on the link between depression and anxiety in patients suffering from tinnitus. Method: A systematic review of published English-language literature was performed using PubMed, Ovid, and Cochrane databases. Results: Of the 56 eligible abstracts 15 were chosen to be included in the review. All articles showed an association of depression and anxiety in tinnitus patients. Conclusions: Because of the strong association between tinnitus, depression, and anxiety-all tinnitus patients should be screened for psychiatric disorders. Treatment for these complex conditions should involve a multidisciplinary team with cognitive behavioral therapy and possible pharmacological therapy.

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Section: Resultsmentioning

confidence: 99%

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Ziai¹,

Moshtaghi²,

Mahboubi³

et al. 2017

The International Tinnitus Journal

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show abstract

“…It has been known that corticosteroids pass into the inner ear and attach to their own receptors. Those receptors have been shown predominantly in the spiral ligament, and then organ of Corti and stria vascularis in the human inner ear [20] . Ion homeostasis, immune suppression, and free radical scavenging effects of those agents made them to be used to protect cochlea, particularly in ototoxic drug use and acoustic trauma [21] .…”

Section: Discussionmentioning

confidence: 99%

Selective Window Application of Gentamicin Dexamethasone in Meniere's Disease

Ardıç

Tümkaya²,

Aykal³

et al. 2017

Int Adv Otol

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OBJECTIVE:The purpose of the study is to prevent hearing loss when using intratympanic (IT) gentamicin for intractable Meniere's disease. MATERIALS and METHODS:It is a retrospective case review study. Twenty five patients who had definite Meniere's disease and had either selective window application or weekly IT gentamicin were included into the study. First group (selective) had dexamethasone on the round window and gentamicin on oval window during exploratory tympanotomy procedure. The second group had IT gentamicin at weekly intervals. The degree of caloric weakness (CW), average hearing level in low pitch (HLP) (250, 500, 1000, 2000 Hz) and high pitch (HHP) (4000, 6000, 8000 Hz) were compared before and after treatment. The need for further treatment was noted. RESULTS:In the first group, the average HLP was increased from 51.6±7dB to 52.2±5.6 dB. The average HHP was increased 41.96±20.2 dB to 47.2±18.3 dB after treatment. The CW changed from 37.6±23.9 % to 54.6±30.6 %. In the second group, the average HLP was increased from 56.3±10.5 dB to 61.65±18.3 dB. The average HHP was increased 59.05±17.4 dB to 69.4±21.98 dB after treatment. The CW changed from 45.8±22.3% to 71.53±29.63 %. Both methods had statisticaly significant increase in caloric weakness. But only IT gentamicin led a significant hearing loss in HHP. CONCLUSION:The use of dexamethasone and gentamycin via different windows in the middle ear is safe and effective method for Meniere's disease in the short term. Application of dexamethasone protects not only the hearing cells but vestibular cells also.

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“…Mammalian and human cochleas have glucocorticoid receptors [6,20], thus specific reaction is expected when local steroids is given. However, our research didn't show consistent effect of DEX on CoBF, which meant DEX might not affect the cochlea by changing the blood flow.…”

Section: Discussionmentioning

confidence: 99%

Intratympanic Dexamethasone on Cochlear Blood Flow in Guinea Pigs

Chiang

Yeh

Chiang

et al. 2012

Indian J Otolaryngol Head Neck Surg

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To determine the effect of intratympanically delivered dexamethasone on cochlear blood flow. 29 white Hartly guinea pigs were divided into 2 groups. By laser Doppler flowmeter, baseline data were recorded in the first 15-20 min, followed by 20 min' recording after applying dexamethasone or normal saline, with a record of flow every 5 min in 2 groups. Friedman Test was used to test the change of blood flow in these four timing. There were no significant changes of blood flow after injecting dexamethasone (p = .18 [ .05) and normal saline (p = .93 [ .05). The effects of dexamethasone on cochlear blood flow were variable and not significant. The following research would be designed under pathological conditions, such as cochlear ischemia, to show the possible mechanism of dexamethasone for specific inner ear disease. Level of evidence: 3a (SR of case-control studies).

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Receptors for Glucocorticoids in the Human Inner Ear

Cited by 123 publications

References 17 publications

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Selective Window Application of Gentamicin Dexamethasone in Meniere's Disease

Intratympanic Dexamethasone on Cochlear Blood Flow in Guinea Pigs

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