Receptors for 5-hydroxytryptamine on the sympathetic nerves of the rabbit heart

Fozard, John R.; Ali, Aftab

doi:10.1007/bf00507041

Cited by 97 publications

(27 citation statements)

References 29 publications

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“…Although the effect of 5-HT on the heart rate of the intact animal is complex involving activation of vagal fibres (Paintal, 1973;Fozard, 1984) as well as the release of catecholamines (Trendelenburg, 1960; Fozard & Moborak Ali, 1978), our study was not complicated by such mechanisms, since the cats were both bilaterally vagosympathectomised and pretreated with a high dose of the P-adrenoceptor blocking agent, propranolol. Under these conditions, both 5-HT and 5-CT produced dose-related increases in heart rate.…”

Section: Discussionmentioning

confidence: 99%

5‐Carboxamidotryptamine is a selective agonist at 5‐hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats

Connor¹,

Feniuk²,

Humphrey³

et al. 1986

British J Pharmacology

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Section: Discussionmentioning

confidence: 99%

5‐Carboxamidotryptamine is a selective agonist at 5‐hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats

Connor¹,

Feniuk²,

Humphrey³

et al. 1986

British J Pharmacology

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“…Both effects can be measured in the rabbit isolated heart using the Langendorff technique (39,102). In the presence of muscarinic antagonists, 5-HT has positive chronotropic and inotropic actions which are mediated via the sympathetic nervous system.…”

Section: B Sympathetic and Parasympathetic Nervous Systemsmentioning

confidence: 99%

5‐HT₃ receptors

Kilpatrick¹,

Bunce²,

Tyers³

1990

Medicinal Research Reviews

182

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“…Gaddum and Picarelli (14) first classified the 5-HT receptors of the bowel as "D" or "M" receptors because they found responses of the guinea pig ileum to 5-HT that could be blocked by phenoxybenzamine (dibenzyline) or morphine, respectively. Although neither of these compounds is a specific antagonist of 5-HT, the terms D and M are now well established and each denotes a distinct receptor population (15)(16)(17)(18). The D receptors are located on smooth muscle, whereas the M receptors are entirely neural.…”

mentioning

confidence: 99%

Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists.

Mawe¹,

Branchek²,

Gershon³

1986

Proc. Natl. Acad. Sci. U.S.A.

170

103

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Serotonin (5-hydroxytryptamine, 5-HT) has been shown to be a neurotransmitter in the enteric nervous system (ENS). Although 5-HT is a mediator of slow excitatory postsynaptic potentials evoked by stimulation of interganglionic connectives, the precise role it plays in the physiology of the gut is unclear. Research has been hampered by an inadequate knowledge of the types of 5-HT receptor in the ENS and thus the lack of well-characterized antagonists. We now report the identification of two classes of enteric neural 5-HT receptor, the effects of activating these receptors on myenteric type II/AH neurons, and their characterization with specific agonists and antagonists. One class, which we propose to call 5-HT1p, is characterized by a high affinity for [3H]5-HT in radioligand binding assays. This class of receptor mediates a slow depolarization of myenteric type II/AH neurons associated with an increase in input resistance. Agonists at this receptor include, in addition to 5-HT (in order of potency), 5-and 6-hydroxyindalpine and 2-methyl-5-HT. 5-HTlp-mediated Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter in the enteric nervous system (ENS) (1-3). Nevertheless, its precise role in the control of gastrointestinal motility or secretion is not clear. In part, this uncertainty arises because 5-HT has many actions on the neurons, muscle, and epitheHum of the gut and it has been difficult to determine which of these are of physiological significance. The neuronal effects of 5-HT include excitation of mucosal afferent fibers to initiate the peristaltic reflex (4, 5), a presynaptic inhibition of the release of acetylcholine (AcCho) from activated myenteric axons (6), stimulation of excitatory enteric neurons to cause a net release of AcCho resulting in smooth muscle contraction, and a relaxation of the bowel secondary to the activation of nonadrenergic, noncholinergic inhibitory neurons (7). Direct application of 5-HT onto myenteric type II/AH neurons may result in a rapid depolarization of the cells associated with an increase in membrane conductance (8), a slow depolarization associated with a decreased membrane conductance (9, 10), a hyperpolarization associated with an increase in membrane conductance, or, with different time courses, all of these responses (11-13). The development of an understanding of the physiological significance of the many effects of exogenous 5-HT has been hampered by the absence, until recently, of specific antagonists of the enteric neural actions of the amine.To utilize 5-HT antagonists effectively it is necessary to characterize the types of 5-HT receptor present in the gut. Gaddum and Picarelli (14) first classified the 5-HT receptors of the bowel as "D" or "M" receptors because they found responses of the guinea pig ileum to 5-HT that could be blocked by phenoxybenzamine (dibenzyline) or morphine, respectively. Although neither of these compounds is a specific antagonist of 5-HT, the terms D and M are now well established and each denotes a distinct receptor populat...

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Receptors for 5-hydroxytryptamine on the sympathetic nerves of the rabbit heart

Cited by 97 publications

References 29 publications

5‐Carboxamidotryptamine is a selective agonist at 5‐hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats

5‐Carboxamidotryptamine is a selective agonist at 5‐hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats

5‐HT₃ receptors

Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists.

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Receptors for 5-hydroxytryptamine on the sympathetic nerves of the rabbit heart

Cited by 97 publications

References 29 publications

5‐Carboxamidotryptamine is a selective agonist at 5‐hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats

5‐Carboxamidotryptamine is a selective agonist at 5‐hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats

5‐HT3 receptors

Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists.

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5‐HT₃ receptors