Receptor Status, Proliferating Activity, and c‐erbB2 Oncoprotein

Campani, Daniela; Sarnelli, R; Fontanini, Gabriella; Martini, Leonardo; Cecchetti, D; Luca, Filomena De; Squartini, F

doi:10.1111/j.1749-6632.1993.tb17205.x

Cited by 4 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same inverse correlation was also reported by others when the proliferative activity of the tumors was visualized by Ki67 immunostaining and the ER (PR also) content was evaluated by both biochemical and immunocytochemical determinations [35]. When the proliferative activity was measured by Ki67 or TLI methods, and the ER status was determined by immunohistochemical methods (ER-ICA), the results showed again an inverse correlation between cycling cells and ER status [36,14]. However, Nicholson et al [37] recognized that although an inverse relationship between ER status and proliferative activity may exist, a considerable number of ER-ICA-positive tumors showed high Ki67 staining.…”

Section: Discussionsupporting

confidence: 51%

“…Interestingly, it has been reported recently that synthetic progestins can induce proliferation of breast tumor cell lines via the progesterone or estrogen receptor [49]. The correlation between PR status and proliferative ac-tivity has been the topic of a few studies; the authors have reported an inverse correlation between PR content and proliferative activity in human breast cancer [14,35,36,50]. However, again it has been recognized that a significant population of tumors exists which exhibit a high receptor content and a high growth fraction [50].…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Estrogen receptors, progesterone receptors, and cell proliferation in human breast cancer

Fanelli¹,

Vargas–Roig²,

Gago

et al. 1996

Breast Cancer Res Tr

View full text Add to dashboard Cite

The breast is a target organ for estrogens and progesterone. These hormones control several functions of the normal and abnormal mammary epithelium including cell proliferation. Most of the actions of estrogens and progesterone are mediated via specific steroid receptors, and one would expect that proliferating cells should contain estrogen receptors (ER) and/or progesterone receptors (PR). However, the correlation between receptor expression and cell proliferation is still controversial. In the present study we have examined 29 human breast cancer samples; in 17 of them we evaluated the simultaneous ER and PR localization with that of proliferating cell nuclear antigen (PCNA) and silver-stained nucleolar organizer regions (AgNORs) in a cell-by-cell study. We found that in almost 50% of the tumor biopsies examined, the cells expressing ER were significantly associated with elevated cell proliferation. In another group (38%) there were not significant differences between ER expression and cell proliferation. In only one of the samples (6%) the cells expressing ER showed lower cell proliferation. The study also revealed that in 44% of the tumors the PR expressing cells were associated with elevated cell proliferation. In a second group the PR expression was not significantly associated with cell proliferation (33% of the cases). Finally, in 22% of the samples the cells carrying PR showed lower cell proliferation. We also detected lower ER immunoreactivity in 30% of the breast cancer biopsies with one of the monoclonal antibodies against ER (antibody 1D5 directed against the A/B domain). This group of tumors was PR-negative (or very weakly positive) and had high proliferation. The presence of tumors with 'abnormal' ER proteins and displaying ER/PR significantly associated with elevated cell proliferation could have implications in human breast cancer treatment.

show abstract

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 98%

Estrogen receptors, progesterone receptors, and cell proliferation in human breast cancer

Fanelli¹,

Vargas–Roig²,

Gago

et al. 1996

Breast Cancer Res Tr

View full text Add to dashboard Cite

show abstract

“…The unregulated expression (overexpression) of the c-erbB-2 gene, involved in cellular growth, may be mediated by either amplification or post-translational stabilization and has been reported in 25-30% of primary, heterogeneous human BC cells (381)(382)(383)(384). The expression of the c-erbB-2 oncoprotein has been associated with poor prognosis and high cellular proliferation activity in a variety of human malignancies, including GBMs (385); lung carcinomas (386); gastric carcinomas (387); bladder carcinoma (388); prostate carcinomas (389,390); ovarian carcinomas (366), endometrial carcinomas (391)(392)(393)(394)(395), and BCs (396)(397)(398)(399)(400)(401)(402)(403)(404)(405)(406)(407)(408)(409)(410)(411)(412)(413)(414). In numerous cases, however, no statistically significant correlation between c-erbB-2 expression the prognostication of disease progression could be established (415)(416)(417)(418)(419)(420)(421)(422).…”

Section: Discussionmentioning

confidence: 99%