Receptor protein tyrosine phosphatase β/ζ regulates loss of neurogenesis in the mouse hippocampus following adolescent acute ethanol exposure

Inhibition of RPTPβ/ζ reduces chronic ethanol intake in adolescent mice and modulates ethanol effects on hippocampal neurogenesis and glial responses in a sex-dependent manner

“…The data point again to sex-specific differences in the actions of RPTPβ/ζ in the brain and suggest a beneficial modulation by MY10 of ethanol-induced effects on hippocampal neurogenesis that could be related to the ability of MY10 to regulate ethanol-induced microglial responses. Recently, we have shown that acute treatment with MY10 fully prevents the loss of hippocampal neurogenesis induced by a single administration of ethanol (6 g/kg) in both male and female mice ( Galán-Llario et al, 2022 ). The data indicate that acute effects of MY10 on brain alterations induced by a single administration of ethanol do not differ between males and females ( Galán-Llario et al, 2022 ), but the effects of repeated administrations of MY10 on chronic ethanol consumption are sex-dependent.…”

“…Recently, we have shown that acute treatment with MY10 fully prevents the loss of hippocampal neurogenesis induced by a single administration of ethanol (6 g/kg) in both male and female mice ( Galán-Llario et al, 2022 ). The data indicate that acute effects of MY10 on brain alterations induced by a single administration of ethanol do not differ between males and females ( Galán-Llario et al, 2022 ), but the effects of repeated administrations of MY10 on chronic ethanol consumption are sex-dependent. It has been shown that estrogen induces the expression of RPTPβ/ζ in mice.…”