1981
DOI: 10.1126/science.6258226
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Receptor for Albumin on the Liver Cell Surface May Mediate Uptake of Fatty Acids and Other Albumin-Bound Substances

Abstract: Kinetic analysis of the uptake of carbon-14-labeled oleate in a single-pass perfusion of rat liver and saturable and specific binding of iodine-125-labeled albumin to hepatocytes in suspension suggest the existence of a receptor for albumin on the liver cell surface. The putative receptor appears to mediate uptake of albumin-bound fatty acids by the cell and may account for the efficient hepatic extraction of many other substances tightly bound to albumin.

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Cited by 365 publications
(159 citation statements)
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“…For instance, Weisiger et al 13,16) presented the albumin receptor-mediated transport concept to account for the transport of fatty acid, sulfobromophthalein and bilirubin into the liver, and Forker and Luxon14, 15) suggested the presence of albumin-mediated transport in the liver for rose bengal and taurocholate. Subsequently, we also found an albumin-mediated hepatic uptake of warfarin using the multiple indicator dilution method.31) Pardridge et al 18,19) suggested a "free intermediate model" to explain the transport of many substances such as steroid hormone and l-propranolol (PL) into the brain.…”
Section: Resultsmentioning
confidence: 99%
“…For instance, Weisiger et al 13,16) presented the albumin receptor-mediated transport concept to account for the transport of fatty acid, sulfobromophthalein and bilirubin into the liver, and Forker and Luxon14, 15) suggested the presence of albumin-mediated transport in the liver for rose bengal and taurocholate. Subsequently, we also found an albumin-mediated hepatic uptake of warfarin using the multiple indicator dilution method.31) Pardridge et al 18,19) suggested a "free intermediate model" to explain the transport of many substances such as steroid hormone and l-propranolol (PL) into the brain.…”
Section: Resultsmentioning
confidence: 99%
“…BSP uptake by hepatocytes in the presence of albumin requires the presence of extracellular Cl Ϫ , while a large fraction of taurocholate uptake requires the presence of Na ϩ . 15,17,25 Isosmotic substitution of NaCl by sucrose failed to affect the initial uptake of 55 Fe-heme (Fig. 4B), indicating that heme transport by short-term cultured rat hepatocytes does not require Na ϩ or Cl Ϫ (n ϭ 3).…”
Section: Effect Of Intracellular Atp Depletion and Extracellular Naclmentioning
confidence: 99%
“…It is controversial whether albumin plays a role in the uptake of organic anions by hepatocytes. [25][26][27] One possibility is that the affinity of albumin for the organic anion is a determining factor for the uptake rate. We investigated the effects of albumins with different affinities for heme on the transport of this organic anion.…”
Section: Effect Of Intracellular Atp Depletion and Extracellular Naclmentioning
confidence: 99%
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