Receptor for advanced glycation end products (RAGE) polymorphisms are associated with systemic lupus erythematosus and disease severity in lupus nephritis

Martens, Henk A.; Nienhuis, Hans L A; Gross, Sacha; Steege, Gerrit van der; Brouwer, Elisabeth; Berden, Jo H. M.; Sévaux, R.G.L. de; Derksen, R. H. W. M.; Voskuyl, Alexandre E.; Berger, Stefan P.; Navis, Gerjan; Nolte, Ilja M.; Kallenberg, Cornelis; Bijl, Marc

doi:10.1177/0961203312444495

Cited by 46 publications

(42 citation statements)

References 44 publications

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“…The -429T/C and -374T/A polymorphisms were shown to have a marked effect on the transcriptional activity (Hudson et al, 2001), and the G82S polymorphism occurring in the AGE-binding domain has been shown to have an enhanced binding and cytokine/MMP generation following ligation by a prototypic S100/calgranulin (Hofmann et al, 2002). The associations identified between RAGE polymorphisms and diseases have primarily focused on inflammatory complications such as Crohn's disease, systemic lupus erythematosus, and cardiovascular diseases (Peng et al, 2009;Dabritz et al, 2011;Lu et al, 2011;Martens et al, 2012). However, whether these polymorphisms are associated with the development of COPD has not been studied.…”

Section: Introductionmentioning

confidence: 97%

Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene with COPD in the Chinese Population

Cheng²,

Ma³

et al. 2014

DNA and Cell Biology

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The receptor for advanced glycation end products (RAGE) is a cell surface molecule of the immunoglobulin superfamily that binds diverse endogenous ligands involved in the development of chronic diseases and inflammatory damage. A growing body of evidence has suggested that RAGE is involved in the development and progression of chronic obstructive pulmonary disease (COPD). The present study investigated the existence of an association among three polymorphisms (-374T/A, -429T/C, and G82S) of the RAGE gene with the risk of COPD in the Chinese population. The RAGE genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 216 patients with COPD and 239 age-matched healthy individuals. Our study demonstrated that the frequencies of the GS genotype and the S allele in the G82S mutation were significantly higher in COPD patients than in controls (odds ratios [OR]=1.70, 95% confidence interval [CI]: 1.15-2.50, p=0.0098 and OR=1.42, 95% CI: 1.06-1.91, p=0.023, respectively). Further stratification analysis by smoking status revealed that the presence of the GS genotype conferred a higher risk of developing COPD in current smokers (p=0.044). In contrast, mutations at -374T/A and -429T/C did not demonstrate any association with COPD, even after taking into account the patients' smoking history. Our study provides preliminary evidence that the G82S polymorphism in the RAGE gene is associated with an increased risk of COPD and that the GS genotype of the G82S variant is a risk factor for COPD in the Chinese population.

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Section: Introductionmentioning

confidence: 97%

Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene with COPD in the Chinese Population

Cheng²,

Ma³

et al. 2014

DNA and Cell Biology

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“…The −429 T/C and −374 T/A polymorphisms have been shown to exert significant effects on the transcriptional activity [13], and the G82S polymorphism, which occurs in the AGE binding domain, has been shown to have an enhanced ligand-binding affinity and leads to the increased ligand-stimulated activation of proinflammatory mediators [14]. The functional polymorphisms of the RAGE gene have been studied for their associations with various diseases, including Crohn's disease, systemic lupus erythematosus, Alzheimer's disease, multiple sclerosis, and cardiovascular diseases [15–20]. However, the association between the RAGE polymorphisms and AAA has not yet been determined.…”

Section: Introductionmentioning

confidence: 99%

Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene and Susceptibility to Sporadic Abdominal Aortic Aneurysm

Yao

Zhuang

You

et al. 2015

BioMed Research International

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Accumulating evidence has suggested that receptor for advanced glycation end products (RAGE) is involved in the development and progression of human abdominal aortic aneurysms (AAAs). However, the association between RAGE gene polymorphisms and AAA has not yet been determined. The present study was aimed at analyzing the potential association between the RAGE gene polymorphisms and AAAs. A cohort of 381 patients and 436 age-matched healthy controls were genotyped to detect the three RAGE polymorphisms (−374 T/A, −429 T/C, and G82S) using SNaPshot. Our study demonstrated a significant difference in the genotype and allele frequencies of the RAGE G82S polymorphism between the AAA patients and the controls. Further stratification by gender and smoking status revealed that the presence of the RAGE 82S allele confers a higher risk for developing AAA in men and smokers. Moreover, AAA patients with the variant 82S allele of RAGE presented with reduced serum soluble RAGE (sRAGE) production, and this decrease was more significant in men and smokers with AAA. Our study provides preliminary evidence that the 82S allele of RAGE is a risk factor for AAA. This new piece of knowledge regarding RAGE may be clinically important for the prevention and therapy of AAAs.

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“…Further, Abdulahad et al [58] have reported that urinary HMGB-1 produces disease activity in patients with lupus nephritis. Interestingly, Martens et al [59] have found that some RAGE polymorphism is linked to the susceptibility to SLE and lupus nephritis. These data support the concept that RAGE might play an important role in the pathogenesis of SLE and its related renal complications by mediating the inflammatory responses in the kidney via the interaction with HMGB-1.…”

Section: Receptor For Advanced Glycation Endproducts and Lupus Nephritismentioning

confidence: 97%

Receptor for advanced glycation endproducts and progressive kidney disease

Fukami

Taguchi²,

Yamagishi³

et al. 2015

Current Opinion in Nephrology and Hypertension

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Receptor for advanced glycation end products (RAGE) polymorphisms are associated with systemic lupus erythematosus and disease severity in lupus nephritis

Abstract: RAGE polymorphisms are associated with susceptibility to SLE and LN. In addition, some of these polymorphisms are likely to be associated with disease severity and initial response to treatment in LN.

Cited by 46 publications

References 44 publications

Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene with COPD in the Chinese Population

Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene with COPD in the Chinese Population

Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene and Susceptibility to Sporadic Abdominal Aortic Aneurysm

Receptor for advanced glycation endproducts and progressive kidney disease

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