Abstract:High-mobility group box 1 (HMGB1) and the receptor for advanced glycation end products (RAGE) are thought to play key roles in the progression of chronic inflammatory diseases. We recently showed that HMGB1 and RAGE might be involved in the progression of human gingival inflammation as novel inflammatory mediators. The molecular mechanisms governing the ability of RAGE to induce ligand-specific responses in gingival inflammation are still unknown. We identified HMGB1/S100A4/NF-κβ pathway, a global regulator of… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.