Receptor-based biomimetic NVP/DMA contact lenses for loading/eluting carbonic anhydrase inhibitors

Ribeiro, Andreza Maria; Veiga, Francisco; Santos, Delfim; Torres‐Labandeira, Juan J.; Concheiro, Angel

doi:10.1016/j.memsci.2011.08.030

Cited by 37 publications

(14 citation statements)

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“…The integration of MIPs in, or interaction of MIPs with, biological systems is perhaps the area that has drawn most attention from the scientific community at large over recent years. Two themes dominate this sector, namely the use of MIPs for drug delivery and the development of MIPs with biological function . The use of molecular imprinted materials in conjunction with ocular drug delivery is arguably the sector that has come closest to clinical use.…”

Section: Applicationsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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SummaryHerein we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004 to 2011. In total, 3779 references to the original papers, reviews, edited volumes and monographs from this period are included, along with recently identified uncited materials from prior to 2004 which were omitted in the first instalment of this series covering the years 1930 to 2003. 1 In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by sections describing fundamental aspects of molecular imprinting including the development of novel polymer formats. Thereafter, literature describing efforts to apply these polymeric materials to a range of application areas is presented. Current trends and areas of rapid development are discussed.2

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Section: Applicationsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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“…Prolonged release on the corneal surface of hydrophilic drugs might be better achieved by means of contact lenses or hydrogel films that bear functional moieties suitable for interacting with the drug molecules [15]. Thus, compared with the biomimetic/imprinted contact lenses [15,50], poloxamine micelles may offer higher initial levels of ETOX at the lachrymal fluid; the greater concentration gradient facilitating the passing through the cornea of this high permeability drug. Subsequent application of ETOX-medicated contact lenses may enable the attainment of long-term drug levels.…”

Section: ð3:2þmentioning

confidence: 99%

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Ribeiro

Sosnik

Chiappetta

et al. 2012

J. R. Soc. Interface.

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Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904), possessing a similar number of propylene oxide units but different contents in ethylene oxide, were chosen for the study. The critical micellar concentration and the cloud point of mixed micelles in 0.9 per cent NaCl were slightly greater than the values predicted from the additive rule, suggesting that the co-micellization is hindered. Micellar size ranged between 17 and 120 nm and it was not altered after the loading of ETOX (2.7-11.5 mg drug g -1 poloxamine). Drug solubilization ability ranked in the order: T904 (50-fold increase in the apparent solubility) . T1107 ffi T1307 . T908. Mixed micelles showed an intermediate capability to host ETOX but a greater physical stability, maintaining almost 100 per cent drug solubilized after 28 days. Furthermore, the different structural features of poloxamines and their combination in mixed micelles enabled the tuning of drug release profiles, sustaining the release in the 1-5 days range. These findings together with promising hen's egg test-chorioallantoic membrane biocompatibility tests make poloxamine micelles promising nanocarriers for carbonic anhydrase inhibitors in the treatment of glaucoma.

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“…Carbonic anhydrase inhibitors are used for treatment of glaucoma and other ocular disorders. Ribeiro et al, recently synthetized biomimetic hydrogels suitable as high water-content SCL using N-vinyl-2-pyrrolidone and N,N-Dimethylacrylamide (NVP-DMA) for loading and the delivery of ocular medication acetazolamide and ethoxzolamide (72). Additionally, NVP-DMA hydrogels had a beneficial effect of blocking UV radiation, which will reduce the corneal damage due to UV light (72).…”

Section: ↑ Increasementioning

confidence: 99%

“…Ribeiro et al, recently synthetized biomimetic hydrogels suitable as high water-content SCL using N-vinyl-2-pyrrolidone and N,N-Dimethylacrylamide (NVP-DMA) for loading and the delivery of ocular medication acetazolamide and ethoxzolamide (72). Additionally, NVP-DMA hydrogels had a beneficial effect of blocking UV radiation, which will reduce the corneal damage due to UV light (72). The SCL made with HEMA or NVP presented good oxygen permeability, ensuring more comfort for wearers (86).…”

Section: ↑ Increasementioning

confidence: 99%

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Ribeiro¹,

Figueiras²,

Veiga³

2015

J Pharm Pharm Sci

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-Purpose. Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings in soft contact lenses (SCL) and the applications of novel pharmaceutical systems for ocular drug delivery. Among the new therapeutic approaches in ophthalmology, SCL are novel continuous-delivery systems, providing high and sustained levels of drugs to the cornea. The tendency of research in ophthalmic drug delivery systems development are directed towards a combination of several technologies (bio-inspired and molecular imprinting techniques) and materials (cyclodextrins, surfactants, specific monomers). There is a tendency to develop systems which not only prolong the contact time of the vehicle at the ocular surface, but also at the same time slow down the clearance of the drug. Different materials can be applied during the development of contact lenses and can be combined with natural inspired strategies of drug immobilization and release, providing successful tools for ocular drug delivery systems.

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Receptor-based biomimetic NVP/DMA contact lenses for loading/eluting carbonic anhydrase inhibitors

Cited by 37 publications

References 50 publications

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

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