Receptor Activator of Nuclear Factor-Kappa Ligand and Osteoprotegerin Expressions on Hyperglycemic Wistar Rats (Rattus Novergicus) During Orthodontic Tooth Movement

Alida, Alida; Winoto, Ervina Restiwulan; Narmada, Ida Bagus

doi:10.1590/pboci.2020.145

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…In physiological bone remodelling, a balance should preserve osteoblastic synthesis and osteoclastic resorption. Pathological bone remodelling arises naturally once the balance is disturbed, which leads to destructive bone arthropathies Alida et al 2020 [1] . Orthodontic forces are applied to a tooth and transmitted through the periodontal ligament and alveolar bone.…”

Section: Introductionmentioning

confidence: 99%

RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

Kumar¹,

Raghunath²,

Cha³

2022

Int. J. Appl. Dent. Sci.

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RANKL is a type II membrane protein bearing close homology to TNFSF members TRAIL, FasL, and TNF-a. RANKL has been definite for its key characteristic role in bone metabolism and the immune system. It is an apoptosis regulator gene, a binding partner of osteoprotegerin OPG, a ligand for the receptor RANK, and it controls cell proliferation by modifying protein levels. Osteoblasts and stromal stem cells receptor activator of NFκ-B ligand (RANKL), binds to receptor and RANK, is apparent on the surface of osteoclasts and their predecessors. Osteoprotegerin (OPG) secreted by osteoblasts and osteogenic stromal stem cells keep the skeleton from extreme bone resorption by binding to RANKL and averting it from interacting with RANK osteocytes. The critical cause of RANKL in alveolar bone remodelling during orthodontic tooth movement. The RANKL/OPG proportion in bone marrow is thus a significant element of bone mass in normal and disease conditions. This article reviews the role of the RANKL/RANK/OPG system in bone and other tissues in Orthodontic tooth movement.

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Section: Introductionmentioning

confidence: 99%

RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

Kumar¹,

Raghunath²,

Cha³

2022

Int. J. Appl. Dent. Sci.

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RANK-RANKL-OPG expression after gingival mesenchymal stem cell hypoxia preconditioned application in an orthodontic tooth movement animal model

Nugraha,

Ernawati,

Narmada

et al. 2023

Journal of Oral Biology and Craniofacial Research

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Gingival Medicinal Signaling Cells Conditioned Medium effect on the Osteoclast and Osteoblast number in Lipopolysaccharide-induced Calvaria Bone Resorption in Wistar Rats’ (Rattus novergicus)

Ramadhani

Nugraha

Ihsan

et al. 2021

RJPT

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The gingival medicinal signaling cells conditioned medium (GMSCs-CM) is a biocompatible material which possessed beneficial cytokine, anti-microbial peptide, growth factor that can be collected after culture. GMSCs- CM may inhibit bone resorption in order to improve the patient’s quality of life. In this study, the potential effect of GMSCs-CM on the number of osteoclasts and osteoblasts in Lipopolysaccharide (LPS)-induced calvaria bone resorption in wistar rats (Rattus novergicus) has been analyzed. Twenty-eight male and healthy wistar rats (R. novergicus) at the age of 1-2 months old with 250-300 grams body weight were divided into 4 groups, namely PBS group: 100μg PBS day 1-7; LPS group: 100μg LPS day 1-7; LPS and GMSCs group: 100μg LPS + 100μg GMSCS-CM day 1 1-7, GMSCs group: 100μg M-GMSCs day 1-7. Escherichia Coli LPS was used to induce the bone resorption on the calvaria with subcutaneous injection. GMSCs-CM was collected after passage 4-5 then injected subcutaneously on the calvaria. All samples were examined on the. 8th day through cervical dislocation. The number of osteoblasts and osteoclasts in calvaria was then observed under 400x magnification. One Way ANOVA and Tukey HSD were conducted to analyze differences between groups (p<0.01). The number of osteoclasts in calvaria decreased significantly in the LPS + GMSCs-CM group compared to LPS group (p<0.01). The number of osteoblasts in calvaria increased significantly in the LPS + GMSCs-CM group compared to LPS group (p<0.01). GMSCs-CM can reduce the amount of osteoclast significantly and increases the production of osteoblast in LPS-induced calvaria bone resorption in wistar rats (R. novergicus).

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Receptor Activator of Nuclear Factor-Kappa Ligand and Osteoprotegerin Expressions on Hyperglycemic Wistar Rats (Rattus Novergicus) During Orthodontic Tooth Movement

Abstract: How to cite this article: Alida A, Winoto ER, Narmada IB. Receptor activator of nuclear factor-kappa ligand and osteoprotegerin expressions on hyperglycemic Wistar rats (Rattus Novergicus) during orthodontic tooth movement.

Cited by 3 publications

References 21 publications

RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

RANK-RANKL-OPG expression after gingival mesenchymal stem cell hypoxia preconditioned application in an orthodontic tooth movement animal model

Gingival Medicinal Signaling Cells Conditioned Medium effect on the Osteoclast and Osteoblast number in Lipopolysaccharide-induced Calvaria Bone Resorption in Wistar Rats’ (Rattus novergicus)

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