Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides

Abstract

Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of pharmacological activities. Therefore, the therapeutic potential and biomedical applications of quinoxalines have been enhanced by incorporation of the sulfonamide group into their chemical framework. The present review surveyed the literature on the preparation, biological activities and structure-activity relationship (SAR) of quinoxaline sulfonamide derivatives due to their broad range of biomedical activities, such as diuretic, antibacterial, antifungal, neuropharmacological, antileishmanial, anti-inflammatory, anti-tumor and anticancer action. The current biological diagnostic findings in this literature review suggest that quinoxaline-linked sulfonamide hybrids are capable of being established as lead compounds; modifications on quinoxaline sulfonamide derivatives may give rise to advanced therapeutic agents against a wide variety of diseases.

Lysozyme binding with sulfa group of antibiotics: Comparative binding thermodynamics and computational study

“…Therefore, they are bacteriostatic and inhibit the growth and multiplication of micro-organisms. [15][16][17] SN derivatives are an important class of drugs used in clinics as pharmacological agents such as anti-bacterial, anti-tumor, anti-thyroid, anti-fungal, anti-inflammatory, anti-obesity, etc. [18] Recent use of SNs includes anti-cancer, antiviral HIV (HIV protease inhibitors, non-nucleoside HIV reverse transcriptase or HIV integrase inhibitors), [19][20][21] and Alzheimer's disease [22] agents.…”

One pot synthesis of two potent Ag(I) complexes with quinoxaline ligand: X- ray structure, Hirshfeld analysis, antimicrobial, and antitumor investigations

“…Quinoxaline derivatives have been established to have antifungal, antibacterial, and anticancer activities [27][28][29][30][31][32][33][34][35][36] . The combination of quinoxaline with Ag(I) ions results in the formation of complexes with fascinating biological characteristics, which could be an interesting alternatives to the current medications 37 .…”

“…A set of review articles emphasized on Ag(I) complexes with N-heterocycles has targeted their uses as anticancer agents against a variety of cancer cell lines. It has been found that several Ag(I) complexes have greater cytotoxicity than cis-platin with a relatively little poisonous effects to the healthy human cells [19][20][21][22][23][24][25][26] .Quinoxaline derivatives have been established to have antifungal, antibacterial, and anticancer activities [27][28][29][30][31][32][33][34][35][36] . The combination of quinoxaline with Ag(I) ions results in the formation of complexes with fascinating biological characteristics, which could be an interesting alternatives to the current medications 37 .…”

One pot synthesis of two potent Ag(I) complexes with quinoxaline ligand, X-ray structure, Hirshfeld analysis, antimicrobial, and antitumor investigations

“…Quinoxaline derivatives have been established to have antifungal, antibacterial, and anticancer activities 37 – 46 . The combination of quinoxaline with Ag(I) ions results in the formation of complexes with fascinating biological characteristics, which could be an interesting alternatives to the current medications 47 .…”