Recent Updates on Ayurveda based Phytoconstitutents for the Treatment of Diabetes Mellitus

Abstract

Diabetes mellitus is ubiquitous metabolic syndrome with increase rates of mortality from past few decades. It is biochemical disorder with complex pathophysiology and has disturbed glucose homeostasis which is maintained by insulin hormone. The current medications for diabetes mellitus have serious adverse effects after long treatments. Thus, Ayurveda based phytoconstitutents is new and well accepted path for possible discovery of newer drugs for the better management of diabetes and associated diabetic complications. The plants phytoconstitutents are more affordable, clinically effective with less adverse effects profile than the modern allophatic medications. The literature has shown the efficacy and clinical safety of the traditional medicine system. These natural products act by inhibiting alpha amylase and alpha glucosidase enzymes, some act by regulating the insulin secretion and activation of PRARγ pathway for maintaining glucose concentration. These natural treatments were found to be remarkably potent and safe as no adverse effects has been clinically outlined during medical therapy. This review briefly describes the various secondary plant metabolites, their structures and their proposed mechanism of action for treating diabetes mellitus and associated complications.

Nutritional and Antioxidant Potential of Kundru (Coccinia Indica Wight & Arn.) And Kikar (Acacia Nilotica L. Del.) Pods

“…Young leaves and long slender stem tops as well as tender green fruits of the plant are cooked and eaten as a potherb or added to soups (Gunjan et al 2010, Ramakrishnan et al 2011. Ayurveda and Unani systems claim Kundru as antidiabetic agent and other traditional uses are antiinflammatory, antimicrobial, antibacterial, antidepressant and expectorant (Randhawa et al 2015, Kaushik andKaushik 2022).…”