Recent updates in the polysaccharides-based Nano-biocarriers for drugs delivery and its application in diseases treatment: A review

Zhang, Jixian; Zhan, Ping; Tian, Honglei

doi:10.1016/j.ijbiomac.2021.04.009

Cited by 39 publications

(18 citation statements)

References 168 publications

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“…Alterations to the surface area and/or volume of the NPs will lead to modifications of their properties, such as their mechanical, thermal, optical, and catalytic behaviour, which can be exploited in diverse applications, such as in the biological fields [ 20 , 21 ]. In the last decade, the fabrication of NPs based on polysaccharides [ 22 ], polymers [ 23 , 24 ], and plant-derived bioactive compounds [ 25 ] incorporated with active drugs has proven to be efficient in treating various pathological conditions.…”

Section: Types and Methods Of Synthesis Of Nanoparticlesmentioning

confidence: 99%

A Review on Current Designation of Metallic Nanocomposite Hydrogel in Biomedical Applications

Dzulkharnien

Rohani

2022

Nanomaterials

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In the past few decades, nanotechnology has been receiving significant attention globally and is being continuously developed in various innovations for diverse applications, such as tissue engineering, biotechnology, biomedicine, textile, and food technology. Nanotechnological materials reportedly lack cell-interactive properties and are easily degraded into unfavourable products due to the presence of synthetic polymers in their structures. This is a major drawback of nanomaterials and is a cause of concern in the biomedicine field. Meanwhile, particulate systems, such as metallic nanoparticles (NPs), have captured the interest of the medical field due to their potential to inhibit the growth of microorganisms (bacteria, fungi, and viruses). Lately, researchers have shown a great interest in hydrogels in the biomedicine field due to their ability to retain and release drugs as well as to offer a moist environment. Hence, the development and innovation of hydrogel-incorporated metallic NPs from natural sources has become one of the alternative pathways for elevating the efficiency of therapeutic systems to make them highly effective and with fewer undesirable side effects. The objective of this review article is to provide insights into the latest fabricated metallic nanocomposite hydrogels and their current applications in the biomedicine field using nanotechnology and to discuss the limitations of this technology for future exploration. This article gives an overview of recent metallic nanocomposite hydrogels fabricated from bioresources, and it reviews their antimicrobial activities in facilitating the demands for their application in biomedicine. The work underlines the fabrication of various metallic nanocomposite hydrogels through the utilization of natural sources in the production of biomedical innovations, including wound healing treatment, drug delivery, scaffolds, etc. The potential of these nanocomposites in relation to their mechanical strength, antimicrobial activities, cytotoxicity, and optical properties has brought this technology into a new dimension in the biomedicine field. Finally, the limitations of metallic nanocomposite hydrogels in terms of their methods of synthesis, properties, and outlook for biomedical applications are further discussed.

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Section: Types and Methods Of Synthesis Of Nanoparticlesmentioning

confidence: 99%

A Review on Current Designation of Metallic Nanocomposite Hydrogel in Biomedical Applications

Dzulkharnien

Rohani

2022

Nanomaterials

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“…Natural polysaccharides are biocompatible, biodegradable, and non-toxic, making them great candidates for drug delivery. Among them, chitosan (CS) and cyclodextrin (CDs) are commonly used [ 113 , 114 , 115 ] and have demonstrated excellent efficacy in siRNA-mediated gene silencing. Alternatively, polysaccharides can also be combined with other vectors to reduce toxicity.…”

Section: Sirna Nanocarriersmentioning

confidence: 99%

Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review

Tong

Liu

Cao

et al. 2023

IJMS

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Gene therapy has attracted much attention because of its unique mechanism of action, non-toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues. siRNA-based gene therapy can downregulate, enhance, or correct gene expression by introducing some nucleic acid into patient tissues. Routine treatment of hemophilia requires frequent intravenous injections of missing clotting protein. The high cost of combined therapy causes most patients to lack the best treatment resources. siRNA therapy has the potential of lasting treatment and even curing diseases. Compared with traditional surgery and chemotherapy, siRNA has fewer side effects and less damage to normal cells. The available therapies for degenerative diseases can only alleviate the symptoms of patients, while siRNA therapy drugs can upregulate gene expression, modify epigenetic changes, and stop the disease. In addition, siRNA also plays an important role in cardiovascular diseases, gastrointestinal diseases, and hepatitis B. However, free siRNA is easily degraded by nuclease and has a short half-life in the blood. Research has found that siRNA can be delivered to specific cells through appropriate vector selection and design to improve the therapeutic effect. The application of viral vectors is limited because of their high immunogenicity and low capacity, while non-viral vectors are widely used because of their low immunogenicity, low production cost, and high safety. This paper reviews the common non-viral vectors in recent years and introduces their advantages and disadvantages, as well as the latest application examples.

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“…[ 352 , 353 ] Similarly, other proteins have been used as the structural component rather than eliciting any specific effect inherent to that protein. [ 354 , 355 ]…”

Section: Protein Particles In Nanomedicinementioning

confidence: 99%

Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches

Habibi

Mauser

et al. 2022

Advanced Science

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Protein nanoparticles, PNPs, have played a long‐standing role in food and industrial applications. More recently, their potential in nanomedicine has been more widely pursued. This review summarizes recent trends related to the preparation, application, and chemical construction of nanoparticles that use proteins as major building blocks. A particular focus has been given to emerging trends related to applications in nanomedicine, an area of research where PNPs are poised for major breakthroughs as drug delivery carriers, particle‐based therapeutics or for non‐viral gene therapy.

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Recent updates in the polysaccharides-based Nano-biocarriers for drugs delivery and its application in diseases treatment: A review

Cited by 39 publications

References 168 publications

A Review on Current Designation of Metallic Nanocomposite Hydrogel in Biomedical Applications

A Review on Current Designation of Metallic Nanocomposite Hydrogel in Biomedical Applications

Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review

Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches

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