Recent Update on Bacteria as a Delivery Carrier in Cancer Therapy: From Evil to Allies

Pandey, Manisha; Choudhury, Hira; Vijayagomaran, Prathiba A/P; Lian, Pauline Ng Poh; Ning, Tan Jing; Wai, Ng Zing; Xian-Zhuang, Ng; Er, Chong Le; Rahmah, Nur Suraiza Nabila; Kamaruzzaman, Nur Dayana Binti; Mayuren, Jayashree; Candasamy, Mayuren; Gorain, Bapi; Chawla, Pooja; Amin, Mohd Cairul Iqbal Mohd

doi:10.1007/s11095-022-03240-y

Cited by 12 publications

(5 citation statements)

References 92 publications

(37 reference statements)

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“…Tese microorganisms multiply locally in the tumor site, so they stimulate the immune response, and the process of cell apoptosis is also started. However, this method faces probable complications such as inciting infammation, cytokine storm, and the dangers of rapid cell death for other organs [267][268][269]. Nasal administration has been more successful in the administration of intranasal vaccines due to the induction of humoral and cellular immune responses both in the area of entry and the surrounding related areas [270].…”

Section: Routes Of Administration For Engineered Microorganismsmentioning

confidence: 99%

“…Considering that these modifed microbes need to be transferred intact and alive to the target tissue or organ in order to exert their optimal efects, loading them into carriers and covering them with lipid, polysaccharide, cationic nano-liposomes, and alginate helps protect them during the oral route of administration [27]. By comparison of these methods, blood and nasal administration of genetically engineered microbes may be more efective than oral due to their fast reaching to the target sites [269]. On the other hand, oral administration is much better than intranasal administration because it induces a wide immune response [274].…”

Section: Routes Of Administration For Engineered Microorganismsmentioning

confidence: 99%

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Genetically Engineered Microorganisms and Their Impact on Human Health

Mahdizade Ari,

Dadgar,

Elahi

et al. 2024

International Journal of Clinical Practice

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The emergence of antibiotic-resistant strains, the decreased effectiveness of conventional therapies, and the side effects have led researchers to seek a safer, more cost-effective, patient-friendly, and effective method that does not develop antibiotic resistance. With progress in synthetic biology and genetic engineering, genetically engineered microorganisms effective in treatment, prophylaxis, drug delivery, and diagnosis have been developed. The present study reviews the types of genetically engineered bacteria and phages, their impacts on diseases, cancer, and metabolic and inflammatory disorders, the biosynthesis of these modified strains, the route of administration, and their effects on the environment. We conclude that genetically engineered microorganisms can be considered promising candidates for adjunctive treatment of diseases and cancers.

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Section: Routes Of Administration For Engineered Microorganismsmentioning

confidence: 99%

Section: Routes Of Administration For Engineered Microorganismsmentioning

confidence: 99%

Genetically Engineered Microorganisms and Their Impact on Human Health

Mahdizade Ari,

Dadgar,

Elahi

et al. 2024

International Journal of Clinical Practice

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“…Due to the specific safeguard function of nasal mucosa, intranasal vaccination becomes capable of activating local humoral and cellular immune responses at the entrance of the respiratory mucosa, distal mucosal sites, and their associated lymphoid tissues, thereby exerting prevention or therapeutic effects ( Riese et al, 2014 ; Xu et al, 2021 ). Notably, bacterial administration via blood, nasal or intestinal routes is very beneficial for them to quickly reach disease sites, and thus, in most cases, their therapeutic effects are superior to those of oral administration ( Wells and Mercenier, 2008 ; Pandey et al, 2022 ). However, some studies signified that the oral administration of GEBs was able to produce a higher immune response than intranasal immunization ( Wan and Ping, 2021 ).…”

Section: Administration Route and Performance Indicatorsmentioning

confidence: 99%

“…Then, they activate immunogenicity and release toxic molecules to induce cell apoptosis and restrain tumor growth ( Yaghoubi et al, 2020 ; Lin et al, 2021 ). However, this treatment may lead to highly malignant adverse effects because the biological toxicity caused by rapid and massive cell death in highly colonized bacterial tumors is extremely harmful to other normal organs and even induces a cytokine storm, thus leading to patient death ( Karbach et al, 2012 ; Pandey et al, 2022 ). Therefore, the administration route is a key factor in GEB construction for different purposes.…”

Section: Administration Route and Performance Indicatorsmentioning

confidence: 99%

Genetically engineered bacterium: Principles, practices, and prospects

et al. 2022

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Advances in synthetic biology and the clinical application of bacteriotherapy enable the use of genetically engineered bacteria (GEB) to combat various diseases. GEB act as a small ‘machine factory’ in the intestine or other tissues to continuously produce heterologous proteins or molecular compounds and, thus, diagnose or cure disease or work as an adjuvant reagent for disease treatment by regulating the immune system. Although the achievements of GEBs in the treatment or adjuvant therapy of diseases are promising, the practical implementation of this new therapeutic modality remains a grand challenge, especially at the initial stage. In this review, we introduce the development of GEBs and their advantages in disease management, summarize the latest research advances in microbial genetic techniques, and discuss their administration routes, performance indicators and the limitations of GEBs used as platforms for disease management. We also present several examples of GEB applications in the treatment of cancers and metabolic diseases and further highlight their great potential for clinical application in the near future.

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“…Generally, attenuation by modification on lipopolysaccharides, flagella, or other structural proteins is widely practiced. Moreover, with advancements in molecular biology, genetic modification for the delivery of different agents, such as tumor-associated antigens, immunostimulatory molecules, anti-tumor drugs, and nucleotides (DNA or RNA), are extensively accepted approaches [ 28 ]. A bacterial platform targeting cancer therapy is the choice of many researchers, as it possesses many benefits.…”

Section: Attenuated Bacteria For Cancer Therapymentioning

confidence: 99%

Salmonella as a Promising Curative Tool against Cancer

2022

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Bacteria-mediated cancer therapy has become a topic of interest under the broad umbrella of oncotherapy. Among many bacterial species, Salmonella remains at the forefront due to its ability to localize and proliferate inside tumor microenvironments and often suppress tumor growth. Salmonella Typhimurium is one of the most promising mediators, with engineering plasticity and cancer specificity. It can be used to deliver toxins that induce cell death in cancer cells specifically, and also as a cancer-specific instrument for immunotherapy by delivering tumor antigens and exposing the tumor environment to the host immune system. Salmonella can be used to deliver prodrug converting enzymes unambiguously against cancer. Though positive responses in Salmonella-mediated cancer treatments are still at a preliminary level, they have paved the way for developing combinatorial therapy with conventional chemotherapy, radiotherapy, and surgery, and can be used synergistically to combat multi-drug resistant and higher-stage cancers. With this background, Salmonella-mediated cancer therapy was approved for clinical trials by U.S. Food and Drug Administration, but the results were not satisfactory and more pre-clinical investigation is needed. This review summarizes the recent advancements in Salmonella-mediated oncotherapy in the fight against cancer. The present article emphasizes the demand for Salmonella mutants with high stringency toward cancer and with amenable elements of safety by virulence deletions.

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Recent Update on Bacteria as a Delivery Carrier in Cancer Therapy: From Evil to Allies

Cited by 12 publications

References 92 publications

Genetically Engineered Microorganisms and Their Impact on Human Health

Genetically Engineered Microorganisms and Their Impact on Human Health

Genetically engineered bacterium: Principles, practices, and prospects

Salmonella as a Promising Curative Tool against Cancer

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