Recent update of toxicity aspects of nanoparticulate systems for drug delivery

Patnaik, Satyakam; Gorain, Bapi; Padhi, Santwana; Choudhury, Hira; Gabr, Gamal A.; Shadab,; Mishra, Dinesh Kumar; Kesharwani, Prashant

doi:10.1016/j.ejpb.2021.02.010

Cited by 54 publications

(22 citation statements)

References 251 publications

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“…Multiple nanocarriers have been designed to modify therapeutic drugs in such a way that could overcome limitations such as biological barrier, unintended intermolecular interactions, and distribution to many intact or normal tissues. Nanoparticles’ unique characteristics such as being modifiable could be utilized for optical, magnetic, electronic, and biological observation offering several advantages over macro nanoparticles ( Park, 2007 ; Praetorius and Mandal, 2008 ; Patnaik et al, 2021 ; Surekha et al, 2021 ).…”

Section: Nanotechnology In Cancer Targetingmentioning

confidence: 99%

CD44-Targeted Nanocarrier for Cancer Therapy

et al. 2022

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Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties of solid tumors including pancreatic, breast, ovary, brain, and lung cancers. It is a multi-structural glycoprotein of the cell surface which is majorly involved in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and generation of immune responses. Numerous studies focus on the development of nanocarriers for active targeting of the CD44 receptor to improve efficacy of targeting chemotherapy and achieve precise chemotherapy by defining the release, uptake, and accumulation of therapeutic agents. The CD44 receptor has a selective binding affinity towards hyaluronic and chondroitin sulfate (CS). Taking this into consideration, this review focused on the role of CD44 in cancer and its therapy using several nanocarriers such as polymeric/non-polymeric nanoparticles, dendrimer, micelles, carbon nanotubes, nanogels, nanoemulsions etc., for targeted delivery of several chemotherapeutic molecules and nucleic acid. This review also illuminates the role of hyaluronic acid (HA) in cancer therapy, interaction of HA with CD44, and various approaches to target CD44-overexpressed neoplastic cells.

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Section: Nanotechnology In Cancer Targetingmentioning

confidence: 99%

CD44-Targeted Nanocarrier for Cancer Therapy

et al. 2022

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“…It had been reported that a composite coating of zirconia and hydroxyapatite/titanium alloy exhibited a complex surface topography at the micro- and nano-structural level, which dramatically enhanced the osteoblastic cell activity and osseointegration. 117 ZrNp is widely used in fabrication of fixed prosthesis such as crowns and bridges and holds promise as a denture base material. Traditionally polymethyl methacrylate is used, but it's lack of impact and flexural strength limits its service life in sudden drops and masticatory accidents.…”

Section: Disadvantages Of Other Biomaterialsmentioning

confidence: 99%

Review on synthesis, properties and multifarious therapeutic applications of nanostructured zirconia in dentistry

et al. 2022

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“…[103] NPs can also elicit an immune response by damaging cells through mitochondrial stress, DNA damage, and disrupting the structure of cell membrane proteins. [6] These inflammatory responses are unwanted and could be suppressed by rational nanoparticle design. Some images in this figure are © 2021 Wiley-VCH GmbH high biocompatibility, biodegradability, and low toxicity, and are widely used in drug delivery systems.…”

Section: Safety Concernsmentioning

confidence: 99%

“…Natural polymers such as chitosan are biodegradable but potentially less‐efficient due to low mechanical strength and exposure to biofouling. [ 6 ] We propose that, despite limitations of low stability, low drug‐loading capacity, and limited potential for functionalization, biodegradable nanoparticles remain more suitable for clinical use than potentially non‐degradable nanoparticle systems. While the latter may show increased efficiency, they are best utilized in laboratory experimental studies and in vivo in model organisms until their long‐term safety profiles are fully investigated.…”

Section: Safetymentioning

confidence: 99%

Nanomaterial Strategies for Delivery of Therapeutic Cargoes

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et al. 2021

Adv Funct Materials

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Over the last decade, much progress has been made in developing nanoparticle-mediated delivery systems to overcome the limitations of existing in vivo delivery technologies. However, the balance between efficacy and safety continues to limit the clinical translation of nanoscale delivery systems. Furthermore, optimizing delivery efficiency requires tuning nanoparticle type and attachment chemistry, both of which are dependent on the cargo being delivered. While the delivery of protein therapeutics is of particular interest, the complexity inherent to protein cargo introduces additional challenges for cargo loading and stabilization. Advances needed for efficient and safe in vivo nanoparticle delivery systems should prioritize design strategies that co-optimize safety, biodegradability, and covalent functionalization. In this review, the most commonly used non-viral nanoparticles are outlined for delivery of small molecule drug, nucleic acid, and protein therapeutic cargoes and potential strategies are discussed for rationally designing nanoparticle-mediated delivery systems.

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Recent update of toxicity aspects of nanoparticulate systems for drug delivery

Cited by 54 publications

References 251 publications

CD44-Targeted Nanocarrier for Cancer Therapy

CD44-Targeted Nanocarrier for Cancer Therapy

Review on synthesis, properties and multifarious therapeutic applications of nanostructured zirconia in dentistry

Nanomaterial Strategies for Delivery of Therapeutic Cargoes

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