Recent trends of bioconjugated nanomedicines through nose-to-brain delivery for neurological disorders

Agnihotri, Tejas Girish; Jadhav, Govinda Shivaji; Sahu, Bichismita; Jain, Aakanchha

doi:10.1007/s13346-022-01173-y

Cited by 9 publications

(5 citation statements)

References 74 publications

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“…In cases where the molecular sizes of the active polysaccharides exceed the optimal thresholds for passing through the blood–brain barrier, a potential approach to explore is using a nasal spray delivery system. This route of administration, known as nose-to-brain delivery, offers the advantage of circumventing the blood–brain barrier and facilitating the direct transport of therapeutic agents into the brain [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Polysaccharides and Gallic Acid from Amauroderma rugosum against 6-OHDA-Induced Toxicity in SH-SY5Y Cells

Rangsinth,

Pattarachotanant,

Wang

et al. 2024

Molecules

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The pharmacological activity and medicinal significance of Amauroderma rugosum (AR) have rarely been documented. We examined the antioxidant and neuroprotective effects of AR on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in an SH-SY5Y human neuroblastoma cell model of Parkinson’s disease (PD) and explored the active ingredients responsible for these effects. The results showed that the AR aqueous extract could scavenge reactive oxygen species and reduce SH-SY5Y cell death induced by 6-OHDA. In addition, the AR aqueous extract increased the survival of Caenorhabditis elegans upon juglone-induced toxicity. Among the constituents of AR, only polysaccharides and gallic acid exhibited antioxidant and neuroprotective effects. The AR aqueous extract reduced apoptosis and increased the expression of phospho-Akt, phospho-mTOR, phospho-MEK, phospho-ERK, and superoxide dismutase-1 in 6-OHDA-treated SH-SY5Y cells. The polysaccharide-rich AR extract was slightly more potent than the aqueous AR extract; however, it did not affect the expression of phospho-Akt or phospho-mTOR. In conclusion, the AR aqueous extract possessed antioxidant and neuroprotective properties against 6-OHDA-induced toxicity in SH-SY5Y cells. The mechanism of action involves the upregulation of the Akt/mTOR and MEK/ERK-dependent pathways. These findings indicate the potential utility of AR and its active ingredients in preventing or treating neurodegenerative disorders associated with oxidative stress such as PD.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Polysaccharides and Gallic Acid from Amauroderma rugosum against 6-OHDA-Induced Toxicity in SH-SY5Y Cells

Rangsinth,

Pattarachotanant,

Wang

et al. 2024

Molecules

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“…Therefore, researchers and scientists should consider greener options because lignocellulosic conjugated systems have huge promises in several areas, especially medicine, where a hazardous material could negatively affect human health. 17,117,131 Moreover, lignocellulosic biconjugated systems are becoming attractive for environmental and agricultural areas. 71,110 Hence, biomolecules, linkers, and solvents can generate a potential ecotoxicological risk.…”

Section: Lignocellulosic Complexes: Greenness and Future Challengesmentioning

confidence: 99%

“…They connect biomolecules and may impart new properties to the system or enhance existing ones. [6][7][8][9][10][11][12][13][14][15][16][17][18] The primary biomolecules in bioconjugate systems include lipids, proteins, nucleic acids, and carbohydrates. [19][20][21][22][23][24] Lignocellulosic structures are notable in the carbohydrate-bioconjugate domain (Fig.…”

Section: Introductionmentioning

confidence: 99%

Lignocellulosic–biomolecules conjugated systems: green-engineered complexes modified by covalent linkers

Lima,

Ribeiro-Viana,

Plath

et al. 2024

J. Mater. Chem. B

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“…Conventional drug treatment methods, such as acetylcholinesterase inhibitor drugs, often encounter obstacles due to their inadequate solubility, limited bioavailability, and inability to effectively penetrate the blood–brain barrier (BBB) [ 6 ]. Therefore, there is an urgent need to focus on the advancement of novel neurodegenerative disease drugs (NDDs) [ 7 – 8 ]. The major obstacle encountered by NDDs is the selectivity of the BBB, which limits the number of therapeutic substances able to reach the brain in order to induce a positive effect.…”

Section: Introductionmentioning

confidence: 99%

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

He,

Segura Abarrategi,

Bediaga

et al. 2024

Beilstein J. Nanotechnol.

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Neurodegenerative diseases are characterized by slowly progressing neuronal cell death. Conventional drug treatment strategies often fail because of poor solubility, low bioavailability, and the inability of the drugs to effectively cross the blood–brain barrier. Therefore, the development of new neurodegenerative disease drugs (NDDs) requires immediate attention. Nanoparticle (NP) systems are of increasing interest for transporting NDDs to the central nervous system. However, discovering effective nanoparticle neuronal disease drug delivery systems (N2D3Ss) is challenging because of the vast number of combinations of NP and NDD compounds, as well as the various assays involved. Artificial intelligence/machine learning (AI/ML) algorithms have the potential to accelerate this process by predicting the most promising NDD and NP candidates for assaying. Nevertheless, the relatively limited amount of reported data on N2D3S activity compared to assayed NDDs makes AI/ML analysis challenging. In this work, the IFPTML technique, which combines information fusion (IF), perturbation theory (PT), and machine learning (ML), was employed to address this challenge. Initially, we conducted the fusion into a unified dataset comprising 4403 NDD assays from ChEMBL and 260 NP cytotoxicity assays from journal articles. Through a resampling process, three new working datasets were generated, each containing 500,000 cases. We utilized linear discriminant analysis (LDA) along with artificial neural network (ANN) algorithms, such as multilayer perceptron (MLP) and deep learning networks (DLN), to construct linear and non-linear IFPTML models. The IFPTML-LDA models exhibited sensitivity (Sn) and specificity (Sp) values in the range of 70% to 73% (>375,000 training cases) and 70% to 80% (>125,000 validation cases), respectively. In contrast, the IFPTML-MLP and IFPTML-DLN achieved Sn and Sp values in the range of 85% to 86% for both training and validation series. Additionally, IFPTML-ANN models showed an area under the receiver operating curve (AUROC) of approximately 0.93 to 0.95. These results indicate that the IFPTML models could serve as valuable tools in the design of drug delivery systems for neurosciences.

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Recent trends of bioconjugated nanomedicines through nose-to-brain delivery for neurological disorders

Cited by 9 publications

References 74 publications

Neuroprotective Effects of Polysaccharides and Gallic Acid from Amauroderma rugosum against 6-OHDA-Induced Toxicity in SH-SY5Y Cells

Neuroprotective Effects of Polysaccharides and Gallic Acid from Amauroderma rugosum against 6-OHDA-Induced Toxicity in SH-SY5Y Cells

Lignocellulosic–biomolecules conjugated systems: green-engineered complexes modified by covalent linkers

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

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