Recent trends in opioid prescriptions in Korea from 2002 to 2015 based on the Korean NHIS-NSC cohort

Kim, Joungyoun; Shin, Sang-Jun; Yoon, Ji-Hyun; Kim, Hyeong-Seop; Lee, Jae-woo; Kim, Yeseul; Kim, Yongwhan; You, Hyo-Sun; Kang, Hee-Taik

doi:10.4178/epih.e2022029

Cited by 8 publications

(6 citation statements)

References 29 publications

(46 reference statements)

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“…Temporary fluctuations were observed when analyzing the trend in opioid analgesic prescriptions over the past four years; however, no significant overall change was noted. This trend is in contrast with a previous report that showed a sharp increase in opioid prescriptions in South Korea from 2002 to 2015 [ 13 ]. A previous study found that an opioid abuse prevention program within the NIMS reduced opioid overdose events [ 14 ].…”

Section: Discussioncontrasting

confidence: 99%

Current status of opioid prescription in South Korea using narcotics information management system

Yoon,

Kim,

Yoon

et al. 2023

Korean J Pain

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Background Recognizing the seriousness of the misuse and abuse of medical narcotics, the South Korean government introduced the world's first narcotic management system, the Narcotics Information Management System (NIMS). This study aimed to explore the recent one-year opioid prescribing patterns in South Korea using the NIMS database. Methods This study analyzed opioid prescription records in South Korea for the year 2022, utilizing the dispensing/administration dataset provided by NIMS. Public data from the Korean Statistical Information Service were also utilized to explore prescription trends over the past four years. The examination covered 16 different opioid analgesics, assessed by the total number of units prescribed based on routes of administration, type of institutions, and patients’ sex and age group. Additionally, the disposal rate for each ingredient was computed. Results In total, 206,941 records of 87,792,968 opioid analgesic units were analyzed. Recently, the overall quantity of prescribed opioid analgesic units has remained relatively stable. The most prescribed ingredient was oral oxycodone, followed by tapentadol and sublingual fentanyl. Tertiary hospitals had the highest number of dispensed units (49.4%), followed by community pharmacies (40.2%). The highest number of prescribed units was attributed to male patients in their 60s. The disposal rates of the oral and transdermal formulations were less than 0.1%. Conclusions Opioid prescription in South Korea features a high proportion of oral formulations, tertiary hospital administration, pharmacy dispensing, and elderly patients. Sustained education and surveillance of patients and healthcare providers is required.

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Section: Discussioncontrasting

confidence: 99%

Current status of opioid prescription in South Korea using narcotics information management system

Yoon,

Kim,

Yoon

et al. 2023

Korean J Pain

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“… 17 In the United States, death due to opioid-related overdoses have tripled, increasing from 2006 to 2016, and health care costs, criminal justice expenses, and productivity losses associated with opioid misuse were estimated to total $78.5 billion. 18 19 Moreover, cohort studies in Korea have reported that the number of opioid users in the general population has increased and that opioid use is associated with increased mortality, 11 12 20 suggesting that long-term opioid use is becoming a major public health concern that cannot be ignored in Korea.…”

Section: Discussionmentioning

confidence: 99%

Opioid Prescription and Long-Term Survival Outcomes in Adults: A Nationwide Cohort Study in Korea

Oh,

Song

2024

J Korean Med Sci

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Background We aimed to investigate the association between short- and long-term opioid use and long-term mortality in Korea. Methods In this population-based retrospective cohort study, data were obtained from the National Health Insurance Service of South Korea. The study included all adult individuals who were prescribed opioids in 2016. The control group comprised adults not prescribed opioids in 2016 selected using a 1:1 stratified random sampling technique. Participants were categorized into three groups: non-user, opioid 1–89 days user (short-term), and opioid ≥ 90 days user (long-term) groups. The primary endpoint in this study was 5-year all-cause mortality, evaluated from January 1, 2017 to December 31, 2021. Results In total, 4,556,606 adults were included in this study. Of these, 2,070,039 were prescribed opioids at least once. Specifically, 1,592,883 adult individuals were prescribed opioids for 1–89 days, while 477,156 adults were prescribed opioid for ≥ 90 days. In the multivariable Cox regression modelling, the opioid user group had a 28% (hazard ratio [HR], 1.28; 95% confidence interval [95% CI], 1.26–1.29; P < 0.001) higher risk of 5-year all-cause mortality than had the non-user group. Moreover, the opioid 1–89 days and opioid ≥ 90 days user groups had 15% (HR, 1.15; 95% CI, 1.14–1.17; P < 0.001) and 49% (HR, 1.49; 95% CI, 1.47–1.51; P < 0.001) higher risks of 5-year all-cause mortality than had the non-user group, respectively. Conclusion Both short and long-term opioid prescriptions were associated with increased long-term mortality among the Korean adult population.

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“…The MME was also increased 15.06 to 40,727.8 during the same period. Fentanyl had increased most rapidly among prescription opioids (morphine, oxycodone, fentanyl, and hydromorphone) [ 110 ]. Chronic weak opioid users increased from 1.03% in 2002 to 9.62% in 2015, and strong opioid users increased from 0.04% in 2002 to 0.24% in 2015 [ 111 ].…”

Section: Main Bodymentioning

confidence: 99%

Prevention, diagnosis, and treatment of opioid use disorder under the supervision of opioid stewardship programs: it's time to act now

et al. 2022

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The third opium war may have already started, not only due to illicit opioid trafficking from the Golden Crescent and Golden Triangle on the international front but also through indiscriminate opioid prescription and opioid diversion at home. Opioid use disorder (OUD), among unintentional injuries, has become one of the top 4 causes of death in the United States (U.S.). An OUD is defined as a problematic pattern of opioid use resulting in clinically significant impairment or distress, consisting of 2 or more of 11 problems within 1 year, as described by the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition. Observation of aberrant behaviors of OUD is also helpful for overworked clinicians. For the prevention of OUD, the Opioid Risk Tool and the Current Opioid Misuse Measure are appropriate screening tests before and during opioid administration, respectively. Treatment of OUD consists of 3 opioid-based U.S. Food and Drug Administration-approved medications, including methadone, buprenorphine, and naltrexone, and non-opioid-based symptomatic medications for reducing opioid withdrawal syndromes, such as α 2 agonists, β-blockers, antidiarrheals, antiemetics, non-steroidal anti-inflammatory drugs, and benzodiazepines. There are at least 6 recommendable guidelines and essential terms related to OUD. Opioid stewardship programs are now critical to promoting appropriate use of opioid medications, improving patient outcomes, and reducing misuse of opioids, influenced by the successful implementation of antimicrobial stewardship programs. Despite the lack of previous motivation, now is the critical time for trying to reduce the risk of OUD.

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Recent trends in opioid prescriptions in Korea from 2002 to 2015 based on the Korean NHIS-NSC cohort

Cited by 8 publications

References 29 publications

Current status of opioid prescription in South Korea using narcotics information management system

Current status of opioid prescription in South Korea using narcotics information management system

Opioid Prescription and Long-Term Survival Outcomes in Adults: A Nationwide Cohort Study in Korea

Prevention, diagnosis, and treatment of opioid use disorder under the supervision of opioid stewardship programs: it's time to act now

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