Recent trends in cancer therapy: A review on the current state of gene delivery

Yahya, Esam Bashir; Alqadhi, Amaal Mohammed

doi:10.1016/j.lfs.2021.119087

Cited by 147 publications

(95 citation statements)

References 167 publications

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“…Biopolymers with abundant functional groups are regarded as important and attractive ingredients for tissue scaffold fabrication [ 81 ]. The high biocompatibility, non-genotoxicity, and non-cytotoxicity of biopolymers either in solo state or composites, coupled with the variety of chemical and biological functionalities they possess, result in them being promising scaffolds for tissue engineering technology [ 82 , 83 , 84 ]. Biocompatibility is referred to as the ability of the material to interact and function in living tissue/s without any complications [ 85 ].…”

Section: Biopolymer-based Aerogels In Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

et al. 2021

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The global transplantation market size was valued at USD 8.4 billion in 2020 and is expected to grow at a compound annual growth rate of 11.5% over the forecast period. The increasing demand for tissue transplantation has inspired researchers to find alternative approaches for making artificial tissues and organs function. The unique physicochemical and biological properties of biopolymers and the attractive structural characteristics of aerogels such as extremely high porosity, ultra low-density, and high surface area make combining these materials of great interest in tissue scaffolding and regenerative medicine applications. Numerous biopolymer aerogel scaffolds have been used to regenerate skin, cartilage, bone, and even heart valves and blood vessels by growing desired cells together with the growth factor in tissue engineering scaffolds. This review focuses on the principle of tissue engineering and regenerative medicine and the role of biopolymer aerogel scaffolds in this field, going through the properties and the desirable characteristics of biopolymers and biopolymer tissue scaffolds in tissue engineering applications. The recent advances of using biopolymer aerogel scaffolds in the regeneration of skin, cartilage, bone, and heart valves are also discussed in the present review. Finally, we highlight the main challenges of biopolymer-based scaffolds and the prospects of using these materials in regenerative medicine.

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Section: Biopolymer-based Aerogels In Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

et al. 2021

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“…The use of polyethylene terephthalate bottles in the SODIS system in low-income communities raises a public concern of potential chemical release at high temperatures. The use of plastic bottles to expose the water to sunlight, which causes elevation in water temperature, raises health concerns about the potential generation of photoproducts or migration of organic compound from the plastic bottles to treated water, which have been linked with many chronic and genetic disorders [143,144]. A limited number of research studies assessed the adverse health effects and the potential toxicity of consuming the water from SODIS process [145,146].…”

Section: Leaching In Plastic Bottles and Potential Adverse Health Effectsmentioning

confidence: 99%

Insights into Solar Disinfection Enhancements for Drinking Water Treatment Applications

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Poor access to drinking water, sanitation, and hygiene has always been a major concern and a main challenge facing humanity even in the current century. A third of the global population lacks access to microbiologically safe drinking water, especially in rural and poor areas that lack proper treatment facilities. Solar water disinfection (SODIS) is widely proven by the World Health Organization as an accepted method for inactivating waterborne pathogens. A significant number of studies have recently been conducted regarding its effectiveness and how to overcome its limitations, by using water pretreatment steps either by physical, chemical, and biological factors or the integration of photocatalysis in SODIS processes. This review covers the role of solar disinfection in water treatment applications, going through different water treatment approaches including physical, chemical, and biological, and discusses the inactivation mechanisms of water pathogens including bacteria, viruses, and even protozoa and fungi. The review also addresses the latest advances in different pre-treatment modifications to enhance the treatment performance of the SODIS process in addition to the main limitations and challenges.

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“…Many conventional synthetic or petroleum-based polymer-based materials are widely used in pregnant women's daily lives, confirmed by many epidemiological and human monitoring studies their ability to cause serious health issues, including cancers [4][5][6]. The toxic effect of these materials is restricted to pregnant women, but it has been confirmed that such materials can induce genetic alterations, which may lead to a significant genetic deformity in future generations [7,8].…”

Section: Introductionmentioning

confidence: 99%

The Role of Biopolymer-Based Materials in Obstetrics and Gynecology Applications: A Review

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Biopolymers have gained tremendous attention in many daily life applications, including medical applications, in the past few years. Obstetrics and gynecology are two fields dealing with sensitive parts of the woman’s body and her newborn baby, which are normally associated with many issues such as toxicity, infections, and even gene alterations. Medical professions that use screening, examination, pre, and post-operation materials should benefit from a better understanding of each type of material’s characteristics, health, and even environmental effects. The underlying principles of biopolymer-based materials for different obstetric and gynecologic applications may discover various advantages and benefits of using such materials. This review presents the health impact of conventional polymer-based materials on pregnant women’s health and highlights the potential use of biopolymers as a safer option. The recent works on utilizing different biopolymer-based materials in obstetric and gynecologic are presented in this review, which includes suture materials in obstetric and gynecologic surgeries, cosmetic and personal care products, vaginal health, and drug delivery; as well as a wound dressing and healing materials. This review highlights the main issues and challenges of biopolymers in obstetric and gynecologic applications.

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Recent trends in cancer therapy: A review on the current state of gene delivery

Cited by 147 publications

References 167 publications

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

Insights into Solar Disinfection Enhancements for Drinking Water Treatment Applications

The Role of Biopolymer-Based Materials in Obstetrics and Gynecology Applications: A Review

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