Recent trends and updates on ultradeformable and elastic vesicles in ocular drug delivery

Srivastava, Vaibhavi; Singh, Vivek; Khatri, Dharmendra Kumar; Mehra, Neelesh Kumar

doi:10.1016/j.drudis.2023.103647

Cited by 6 publications

(2 citation statements)

References 88 publications

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“…Drug transport to the targeted ocular tissues is impeded by a number of precorneal, dynamic, and static ocular obstacles. The conventional system for ocular drug delivery suffers with the problem of poor bioavailability due to low corneal residence time and the fast elimination of the administered dose from the nasolacrimal drainage system [ 45 ]. Moreover, the target tissues do not retain therapeutic medication levels for a prolonged period of time.…”

Section: Bilosomes As Nanocarrier Drug Delivery System For Treating V...mentioning

confidence: 99%

Emerging Trends in Bilosomes as Therapeutic Drug Delivery Systems

Kaurav,

Tripathi,

Kaur

et al. 2024

Pharmaceutics

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In recent years, there has been a notable surge in the utilization of stabilized bile acid liposomes, chemical conjugates, complexes, mixed micelles, and other drug delivery systems derived from bile acids, often referred to as bilosomes. The molecular structure and interactions of these amphiphilic compounds provide a distinctive and captivating subject for investigation. The enhanced stability of new generation bilosomes inside the gastrointestinal system results in the prevention of drug degradation and an improvement in mucosal penetration. These characteristics render bilosomes to be a prospective nanocarrier for pharmaceutical administration, prompting researchers to investigate their potential in other domains. This review paper discusses bilosomes that have emerged as a viable modality in the realm of drug delivery and have significant promise for use across several domains. Moreover, this underscores the need for additional investigation and advancement in order to comprehensively comprehend the prospective uses of bilosomes and their effectiveness in the field of pharmaceutical administration. This review study explores the current scholarly attention on bilosomes as prospective carriers for drug delivery. Therapeutic areas where bilosomes have shown outstanding performance in terms of drug delivery are outlined in the graphical abstract.

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Section: Bilosomes As Nanocarrier Drug Delivery System For Treating V...mentioning

confidence: 99%

Emerging Trends in Bilosomes as Therapeutic Drug Delivery Systems

Kaurav,

Tripathi,

Kaur

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Apart from their role as a nanocarrier, a novel class of flexible nanovesicles toward effectual transdermal drug delivery system such as transfersomes (Tfs) assists in their rapid penetration via the intercellular lipid pathway of the subcutaneous tissue. They consist of at least one inner aqueous compartment enclosed by a bilayer of concentric phospholipids in combination with edge activator (nonionic surfactant), which helps in solubilizing the stratum corneum (Rai et al., 2017 ; Srivastava et al., 2023 ). Additionally, it has acquired enormous demand in recent years due to well organized and depot release of low and high molecular weight drugs.…”

Section: Introductionmentioning

confidence: 99%