Recent trends and emerging strategies for aptasensing technologies for illicit drugs detection

Soni, Shringika; Jain, Utkarsh; Burke, Donald H.; Chauhan, Nidhi

doi:10.1016/j.jelechem.2022.116128

Cited by 10 publications

(7 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditionally, the majority of drug-detection methods using analytical systems are undertaken using chromatography-based techniques (gas chromatography (GC) and HPLC), spectroscopy techniques (refractive index (RI), UV-Vis, fluorescence, evaporative light scattering, and NMR), or hyphenated approaches (GC-MS and HPLC-MS). Each of these techniques has their own advantages and disadvantages, but among them, three systems are more popular, especially when it comes to drug analysis: UV, fluorescence and MS [133][134][135][136][137][138][139][140][141]. While such techniques have proved to be reliable and allow the analysis and detection of almost all molecules of interest in various samples, they still have unsolvable issues.…”

Section: Comparison Of Electrochemical Sensing and Other Conventional...mentioning

confidence: 99%

Graphene-Based Electrochemical Sensors for Psychoactive Drugs

Boroujerdi

Paul

2022

Nanomaterials

View full text Add to dashboard Cite

Sensors developed from nanomaterials are increasingly used in a variety of fields, from simple wearable or medical sensors to be used at home to monitor health, to more complicated sensors being used by border customs or aviation industries. In recent times, nanoparticle-based sensors have begun to revolutionize drug-detection techniques, mainly due to their affordability, ease of use and portability, compared to conventional chromatography techniques. Thin graphene layers provide a significantly high surface to weight ratio compared to other nanomaterials, a characteristic that has led to the design of more sensitive and reliable sensors. The exceptional properties of graphene coupled with its potential to be tuned to target specific molecules have made graphene-based sensors one of the most popular and well-researched sensing materials of the past two decades with applications in environmental monitoring, medical diagnostics, and industries. Here, we present a review of developments in the applications of graphene-based sensors in sensing drugs such as cocaine, morphine, methamphetamine, ketamine, tramadol and so forth in the past decade. We compare graphene sensors with other sensors developed from ultrathin two-dimensional materials, such as transition-metal dichalcogenides, hexagonal boron nitrate, and MXenes, to measure drugs directly and indirectly, in various samples.

show abstract

Section: Comparison Of Electrochemical Sensing and Other Conventional...mentioning

confidence: 99%

Graphene-Based Electrochemical Sensors for Psychoactive Drugs

Boroujerdi

Paul

2022

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Moreover, owing to the relatively diminished selectivity exhibited by these colorimetric methods, their suitability for codeine-specific determinations is inadequate. [14][15][16] Furthermore, employing alterations in color intensity as a basis for quantitative analysis in colorimetric methods proves to be highly challenging. Therefore, there is a pressing need for a quantitative analytical approach that demonstrates selectivity towards codeine and allows for on-site analysis.…”

Section: Introductionmentioning

confidence: 99%

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

Takahashi,

Shimosaka,

Mori

et al. 2024

Chem. Pharm. Bull.

View full text Add to dashboard Cite

Codeine is a common analgesic drug that is a pro-drug of morphine. It also has a high risk of abuse as a recreational drug because of its extensive distribution as an OTC drug. Therefore, sensitive and selective screening methods for codeine are crucial in forensic analytical chemistry. To date, a commercial analytical kit has not been developed for dedicated codeine determination, and there is a need for an analytical method to quantify codeine in the field. In the present work, potential modulation was combined with electrochemiluminescence (ECL) for sensitive determination of codeine. The potential modulated technique involved applying a signal to electrodes by superimposing an AC potential on the DC potential. When tris(2,2′-bipyridine) ruthenium(II) ([Ru(bpy) 3 ] 2 ) was used as an ECL emitter, ECL activity was confirmed for codeine. A detailed investigation of the electrochemical reaction mechanism suggested a characteristic ECL reaction mechanism involving electrochemical oxidation of the opioid framework. Besides the usual ECL reaction derived from the amine framework, selective detection of codeine was possible under the measurement conditions, with clear luminescence observed in an acidic solution. The sensitivity of codeine detection by potential modulated-ECL was one order of magnitude higher than that obtained with the conventional potential sweep method. The proposed method was applied to codeine determination in actual prescription medications and OTC drug samples. Codeine was selectively determined from other compounds in medications and showed good linearity with a low detection limit (150 ng mL 1 ).

show abstract

“…Recently, aptamers ( Apt ) have emerged as an area of interest and excellent alternatives to chromatography and electrophoresis for active identification [ 11 , 12 ]. They are oligonucleotide-based affinity probes that exhibit advantages of higher selectivity, stability, and sensitivity over antibodies [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Nanomaterial-Modified Impedimetric Aptasensor—A Single-Step Strategy for 3,4-Methylenedioxymethylamphetamine Detection

et al. 2022

Self Cite

View full text Add to dashboard Cite

Developing rapid, sensitive detection methods for 3,4-Methylenedioxymethylamphetamine (MDMA) is crucial to reduce its current misuse in the world population. With that aim, we developed an aptamer-modified tin nanoparticle (SnNP)-based nanoarchitecture as an electrochemical sensor in this study. This platform exhibited a high electron transfer rate with enhanced conductivity arising from its large surface area in comparison to the bare electrode. This observation was explained by the 40-fold higher electroactive surface area of SnNPs@Au, which provided a large space for 1.0 μM AptMDMA (0.68 ± 0.36 × 1012 molecule/cm2) immobilization and yielded a significant electrochemical response in the presence of MDMA. Furthermore, the AptMDMA-modified SnNPs@Au sensing platform proved to be a simple yet ultrasensitive analytical device for MDMA detection in spiked biological and water samples. This novel electrochemical aptasensor showed good linearity in the range of 0.01–1.0 nM for MDMA (R2 = 0.97) with a limit of detection of 0.33 nM and a sensitivity of 0.54 ohm/nM. In addition, the device showed high accuracy and stability along with signal recoveries in the range of 92–96.7% (Relative Standard Deviation, RSD, 1.1–2.18%). In conclusion, the proposed aptasensor developed here is the first to combine SnNPs and aptamers for illicit compound detection, and it offers a reliable platform for recreational drug detection.

show abstract

Recent trends and emerging strategies for aptasensing technologies for illicit drugs detection

Cited by 10 publications

References 108 publications

Graphene-Based Electrochemical Sensors for Psychoactive Drugs

Graphene-Based Electrochemical Sensors for Psychoactive Drugs

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

Development of Nanomaterial-Modified Impedimetric Aptasensor—A Single-Step Strategy for 3,4-Methylenedioxymethylamphetamine Detection

Contact Info

Product

Resources

About