Recent trends and advancements in electrochemiluminescence biosensors for human virus detection

Sobhanie, Ebtesam; Salehnia, Foad; Xu, Guobao; Hamidi, Yalda N.; Arshian, Shayesteh; Firoozbakhtian, Ali; Hosseini, Morteza; Ganjali, Mohammad Reza; Hanif, Saima

doi:10.1016/j.trac.2022.116727

Cited by 46 publications

(25 citation statements)

References 87 publications

(96 reference statements)

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“…The ECL technology has attracted great interest of multidisciplinary researchers because it possesses unique superiorities including near-zero background, strong controllability, wide dynamic range, remarkable versatility, etc. , Gold nanoclusters (AuNCs) are appealing with excellent biocompatibility, unique optoelectronic properties, and high recognition reactivity, which have gradually become a promising emerging family of ECL emitters . In recent years, ECL sensors based on AuNCs have been introduced and widely used for biological detection. , To date, various AuNC-based ECL-sensing platforms with distinct mechanisms have been evidenced, such as ECL resonance energy transfer (ECL-RET), , co-reaction catalysis, protein hydrogel-based antibiofouling sensing strategy, and aggregation-induced ECL . Our group also focuses on this field and proposes valence state regulation, split-type ECL assay platform, , competing reaction-sensing strategy, two-in-one ECL probe immunoassay platform, and co-reactant-mediated low-potential anodic ECL technique .…”

Section: Introductionmentioning

confidence: 99%

“…4 In recent years, ECL sensors based on AuNCs have been introduced and widely used for biological detection. 4,5 To date, various AuNC-based ECL-sensing platforms with distinct mechanisms have been evidenced, such as ECL resonance energy transfer (ECL-RET), 6,7 coreaction catalysis, 8 protein hydrogel-based antibiofouling sensing strategy, 9 and aggregation-induced ECL. 10 Our group also focuses on this field and proposes valence state regulation, 11 split-type ECL assay platform, 12,13 competing reaction-sensing strategy, 14 two-in-one ECL probe immunoassay platform, 15 and co-reactant-mediated low-potential anodic ECL technique.…”

Section: ■ Introductionmentioning

confidence: 99%

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Gold Nanocluster Probe-Based Electron-Transfer-Mediated Electrochemiluminescence Sensing Strategy for an Ultrasensitive Copper Ion Detection

Weng

Zhang

et al. 2022

Anal. Chem.

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Exploration of a novel and efficient sensing mechanism of Au nanocluster (AuNC)-based electrochemiluminescence (ECL) sensors is still a great challenge and opportunity for further applications. Herein, we proposed that the electron transfer (ET) could be used as a novel sensing regulation factor for the construction of an ECL-sensing platform based on the AuNC probe. As a proof-of-concept, the ECL quenching effect and mechanism of Cu2+ on pre-oxidation-treated l-methionine-capped AuNCs (OM-AuNCs) was investigated in detail. The results revealed that after the electrochemical excitation of the AuNC probe, the electron is transferred from the highest occupied molecular orbital (HOMO) of Met-Cu2+ to that of the OM-AuNCs, along with the ET from lowest-unoccupied molecular orbital (LUMO) of the OM-AuNCs back to the HOMO of Met-Cu2+, leading to the ECL quenching of OM-AuNCs. Since the ECL intensity of OM-AuNCs is sensitively affected by the ET process, a preferable linear dependence was obtained in the concentration range from 1.0 × 10–18 to 1.0 × 10–14 M with high selectivity. More importantly, a record low detection limit (LOD, 2.3 × 10–20 M) at the single copper ion level has been realized without any other amplification technique. Furthermore, the actual sample detection for Cu2+ exhibited satisfactory results. Therefore, this study enriches an ET-mediated ECL application and promotes a more rational design of ECL sensors.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Gold Nanocluster Probe-Based Electron-Transfer-Mediated Electrochemiluminescence Sensing Strategy for an Ultrasensitive Copper Ion Detection

Weng

Zhang

et al. 2022

Anal. Chem.

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“…Likewise, Yue et al [251] used Ce-MOF/Ti 3 C 2 composite as an electrode matrix for the development of an electrochemical L-tryptophan sensor with good stability and reproducibility. Wang et al [252] constructed a Ti 3 C 2 /ZIF-8 nanocomposite for the detection of HIV-1 in real sample mediums. [240] F,G) scheme showing the oxidative process on PDI-MXene based designed dopamine sensor; H) SEM of PDI-MXene; [241] I) Ti 3 C 2 T x -based Metal-organic framework for the analysis of the ORAV 1; J) TEM; K) HRTEM of Ag NPs/Ti 3 C 2 T x -PMOF.…”

Section: Mxene-metal-organic Framework (Mof)mentioning

confidence: 99%

2D MXene‐Based Biosensing: A Review

Amara

Hussain

Ahmad

et al. 2022

Small

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MXene emerged as decent 2D material and has been exploited for numerous applications in the last decade. The remunerations of the ideal metallic conductivity, optical absorbance, mechanical stability, higher heterogeneous electron transfer rate, and good redox capability have made MXene a potential candidate for biosensing applications. The hydrophilic nature, biocompatibility, antifouling, and anti‐toxicity properties have opened avenues for MXene to perform in vitro and in vivo analysis. In this review, the concept, operating principle, detailed mechanism, and characteristic properties are comprehensively assessed and compiled along with breakthroughs in MXene fabrication and conjugation strategies for the development of unique electrochemical and optical biosensors. Further, the current challenges are summarized and suggested future aspects. This review article is believed to shed some light on the development of MXene for biosensing and will open new opportunities for the future advanced translational application of MXene bioassays.

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“…For now, most of the reported ECL biosensors and all commercial ECL assays are developed based on the ECL luminescent reagent tris(2,2′-bipyridineruthenium(II) ([Ru(bpy) 3 ] 2+ ) [ 22 , 62 ]; however, the quantum yield of [Ru(bpy) 3 ] 2+ is low, which can limit the sensitivity of the assays. Cyclometalated iridium complexes, which exhibit higher luminescence efficiency and long excited state lifetimes, have been reported as alternative luminescent reagents for [Ru(bpy) 3 ] 2+ .…”

Section: Efficient Ecl Luminophoresmentioning

confidence: 99%

Strategies for Enhancing the Sensitivity of Electrochemiluminescence Biosensors

et al. 2022

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Electrochemiluminescence (ECL) has received considerable attention as a powerful analytical technique for the sensitive and accurate detection of biological analytes owing to its high sensitivity and selectivity and wide dynamic range. To satisfy the growing demand for ultrasensitive analysis techniques with high efficiency and accuracy in complex real sample matrices, considerable efforts have been dedicated to developing ECL strategies to improve the sensitivity of bioanalysis. As one of the most effective approaches, diverse signal amplification strategies have been integrated with ECL biosensors to achieve desirable analytical performance. This review summarizes the recent advances in ECL biosensing based on various signal amplification strategies, including DNA-assisted amplification strategies, efficient ECL luminophores, surface-enhanced electrochemiluminescence, and ratiometric strategies. Sensitivity-enhancing strategies and bio-related applications are discussed in detail. Moreover, the future trends and challenges of ECL biosensors are discussed.

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Recent trends and advancements in electrochemiluminescence biosensors for human virus detection

Cited by 46 publications

References 87 publications

Gold Nanocluster Probe-Based Electron-Transfer-Mediated Electrochemiluminescence Sensing Strategy for an Ultrasensitive Copper Ion Detection

Gold Nanocluster Probe-Based Electron-Transfer-Mediated Electrochemiluminescence Sensing Strategy for an Ultrasensitive Copper Ion Detection

2D MXene‐Based Biosensing: A Review

Strategies for Enhancing the Sensitivity of Electrochemiluminescence Biosensors

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