Recent trend of polychlorinated dibenzo-p-dioxins and their related compounds in the blood and sebum of Yusho and Yu-Cheng patients

Iida, Takao; Hirakawai, Hironori; Matsueda, Takahiko; Takenaka, Shigeyuki; Yu, Mei-Lin; Guo, Yang

doi:10.1016/s0045-6535(98)00360-9

Cited by 43 publications

(17 citation statements)

References 2 publications

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“…Elderly women are more often anemic than younger individuals and men, so the half-life of 2,3,4,7,8-PeCDF may be long in older women, which may result in the blood concentration of 2,3,4,7,8-PeCDF in female Yusho patients being higher than that in males. Furthermore, a previous study (Iida et al, 1999) demonstrated that the concentrations of PCDFs, PCDDs and coplanar PCBs in blood and sebum from Yusho and Yucheng patients 17 or 26 years after the initial incident, respectively, clearly reflected the chemical concentrations in the ingested contaminated oil. The secretion of sebum including dioxins may be one of the pathways of dioxins excretion in Yusho, and differences in the amounts of sebum between females and males may explain why female Yusho patients have higher dioxins levels than males.…”

Section: Discussionmentioning

confidence: 88%

“…Ligand-specific activation of AhR induces hyperkeratinization by upregulating the expression of epidermal differentiation complex genes (e.g., filaggrin, loricrin and involucrin) (Kennedy et al, 2013). Highly lipophilic dioxins appear to accumulate in and are excreted via sebaceous glands and sebum (Iida et al, 1999), which may involve their efficient excretion from the body (Matsumoto et al, 2013). These factors may explain why the patients still complain of black comedones and other symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Current skin symptoms of Yusho patients exposed to high levels of 2,3,4,7,8-pentachlorinated dibenzofuran and polychlorinated biphenyls in 1968

et al. 2015

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Current skin symptoms of Yusho patients exposed to high levels of 2,3,4,7,8-pentachlorinated dibenzofuran and polychlorinated biphenyls in 1968

et al. 2015

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“…7,17) However, it has been demonstrated that sebum plays an important role in excretion in addition to feces. 12,18) Thus, in this study, we clarified levels of daily intake from meals and daily excretion from feces and sebum in men, by analyzing the levels of 20 congeners of polychlorinated dibenzo-p-dioxin (PCDD), polychlorinated dibenzofuran (PCDF) and coplanar polychlorinated biphenyl (Co-PCB). We also analyzed blood levels of dioxins to clarify body burden.…”

Section: Introductionmentioning

confidence: 99%

Balance of Intake and Excretion of 20 Congeners of Polychlorinated Dibenzo-p-dioxin, Polychlorinated Dibenzofuran and Coplanar Polychlorinated Biphenyl in Healthy Japanese Men.

Kitamura

Nagahashi

Sunaga

et al. 2001

JOURNAL OF HEALTH SCIENCE

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Daily intake from meals, and excretion from feces and sebum of 20 congeners of polychlorinated dibenzo-pdioxin (PCDD), polychlorinated dibenzofuran (PCDF) and coplanar polychlorinated biphenyl (Co-PCB) were analyzed in healthy Japanese men who are considered to be a standard for the Japanese. Daily intake of these congeners was 84.2 ± 12.5 pg toxic equivalent (TEQ) and daily excretion from feces and sebum were 18.3 ± 5.9 and 23. 8 ± 5.6 pg TEQ, respectively, indicating 22% the daily intake of dioxins from meals is excreted from feces and 29% from sebum. 1,2,3,7,8-Pentachlorodibenzo-p-dioxin (1,2,3,7,2,3,4,7,3,4,7, and 3,3′,4,4′,5-pentachlorobiphenyl (3,3′, 4,4′,5-PeCB) were most abundant in TEQ, in meals, feces, sebum and blood. Co-PCBs were most efficiently excreted among three congener groups in TEQ, especially from sebum. Octachlorodibenzo-p-dioxin (OCDD), 2,3,7,3,7, and 3,3′,4,4′-tetrachlorobiphenyl (3,3′,4,4′-TCB) were well absorbed from intestine and excreted at more than 100% of intake, mainly from the sebum. In contrast, 1,2,3,4,7,2,3,4,7,2,3,7,8,2,3,7,8, were excreted at relatively low levels from sebum, although well absorbed from the intestine, and the excretion ratios were lowest among the 20 congeners. It was suggested that 80.5-85.2% TEQ of each congener-group might be absorbed from the intestine, after taking bile excretion into consideration.

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“…The hypothesis of a link between organochlorine exposure and breast cancer is challenged by the study of accidentally exposed populations. People accidentally exposed to mixtures containing PCBs, polychlorinated dibenzo-dioxins and -furans in central Taiwan in 1979 and in western Japan in 1968 (45,46), and to dioxin in 1976 in Seveso, Italy (47), have not yet been reported to have an increased rate of breast cancer.…”

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confidence: 99%

Modulatory effects of neonatal exposure to TCDD, or a mixture of PCBs, p,p'-DDT, and p-p'-DDE, on methylnitrosourea-induced mammary tumor development in the rat.

Desaulniers

Leingartner

Russo

et al. 2001

Environ Health Perspect

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The role of organochlorine (OC) exposure in the etiology of breast cancer remains controversial. Thus, our objective was to determine whether the most abundant and toxic OCs found in human milk could, when ingested during the neonatal period, modulate the development of mammary tumors in the rat. We prepared a mixture composed of p,p'-dichlorodiphenyltrichloroethane (DDT), its major metabolite, p,p'-dichlorodiphenyldichloroethene (DDE), and 19 polychlorinated biphenyls (PCB) based on their concentrations found in the milk of Canadian women. Neonate rats at 1, 5, 10, 15, and 20 days of age were gavaged with this mixture, at 10, 100, and 1,000 times the amount that a human baby would consume. An additional group received 2.5 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg body weight (bw) by gavage at 18 days of age, instead of the mixture. On day 21, all treatment groups, except for a control group and a 1,000-mix group, received a single intraperitoneal injection of methylnitrosourea (MNU, 30 mg/kg bw), the initiator of the carcinogenic process. The average number of rats per treatment group was 33. Rats were sacrificed when their tumors reached 1 cm in size, or at 308 days of age. We prepared mammary tumors and mammary gland whole mounts for histologic analysis. There were no significant effects when only the malignant or only the benign tumors were considered. After all benign and malignant lesions were pooled, the number of mammary tumors differed among all MNU-treated groups (p = 0.02) with more lesions developing in the MNU-1,000[times] (median = 4.5; p = 0.05) and MNU-TCDD (median = 5.5; p = 0.07) compared to the MNU-0 rats (median = 2). Compared to the MNU-0 group, the percentage of rats that developed palpable tumors (benign plus malignant) was slightly higher (p = 0.06) in the MNU-TCDD group, but not in the MNU-1,000[times] group. The percentage of palpable tumors that were malignant was higher (p = 0.02) in the MNU-100[times] group (15/16, 94%) than in the MNU-0 group (10/18, 56%). The highest dose of the mixture delayed (p = 0.03) the development of tumors, but this was not observed with the MNU-TCDD treatment. These results suggest that neonatal exposure to high doses of organochlorines could favor the development of MNU-induced mammary lesions, but also delays the development of palpable tumors in the rat.

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Recent trend of polychlorinated dibenzo-p-dioxins and their related compounds in the blood and sebum of Yusho and Yu-Cheng patients

Cited by 43 publications

References 2 publications

Current skin symptoms of Yusho patients exposed to high levels of 2,3,4,7,8-pentachlorinated dibenzofuran and polychlorinated biphenyls in 1968

Current skin symptoms of Yusho patients exposed to high levels of 2,3,4,7,8-pentachlorinated dibenzofuran and polychlorinated biphenyls in 1968

Balance of Intake and Excretion of 20 Congeners of Polychlorinated Dibenzo-p-dioxin, Polychlorinated Dibenzofuran and Coplanar Polychlorinated Biphenyl in Healthy Japanese Men.

Modulatory effects of neonatal exposure to TCDD, or a mixture of PCBs, p,p'-DDT, and p-p'-DDE, on methylnitrosourea-induced mammary tumor development in the rat.

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