Recent toxicological investigations of metal or metal oxide nanoparticles in mammalian models in vitro and in vivo: DNA damaging potential, and relevant physicochemical characteristics

Koedrith, Preeyaporn; Boonprasert, Rattana; Kwon, Jee Young; Kim, Im-Soon; Seo, Young Rok

doi:10.1007/s13273-014-0013-z

Cited by 16 publications

(15 citation statements)

References 118 publications

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“…weight), were disregarded. In addition, genotoxicity tests were excluded because of the difficult comparability with other toxicological studies and their linkage to potential mutagenicity carcinogenic effects, which are considered outside the scope of the study (Koedrith et al 2014). Only studies including investigations of non-cancer effects were considered (although studies investigating cancer effects are also reported in Tables S1 and S2).…”

Section: Identification Selection and Classification Of Studiesmentioning

confidence: 99%

Human health no-effect levels of TiO2 nanoparticles as a function of their primary size

et al. 2017

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Section: Identification Selection and Classification Of Studiesmentioning

confidence: 99%

Human health no-effect levels of TiO2 nanoparticles as a function of their primary size

et al. 2017

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“…One of the most commonly suggested mechanisms of toxicity is the generation of reactive oxygen species (ROS) by the nanoparticles [ 64 ]. More specifically, the interaction of metal oxide nanoparticles, including IONPs with biological cells has led to the observation of different types of DNA damage, including: chromosomal aberrations, DNA strand breakage, oxidative DNA damage and mutations [ 65 ].…”

Section: Mutagenic Impact Of Ionps On Cell Linesmentioning

confidence: 99%

Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells

Dissanayake

Obare

2015

IJMS

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In recent years, there has been an increased interest in the design and use of iron oxide materials with nanoscale dimensions for magnetic, catalytic, biomedical, and electronic applications. The increased manufacture and use of iron oxide nanoparticles (IONPs) in consumer products as well as industrial processes is expected to lead to the unintentional release of IONPs into the environment. The impact of IONPs on the environment and on biological species is not well understood but remains a concern due to the increased chemical reactivity of nanoparticles relative to their bulk counterparts. This review article describes the impact of IONPs on cellular genetic components. The mutagenic impact of IONPs may damage an organism’s ability to develop or reproduce. To date, there has been experimental evidence of IONPs having mutagenic interactions on human cell lines including lymphoblastoids, fibroblasts, microvascular endothelial cells, bone marrow cells, lung epithelial cells, alveolar type II like epithelial cells, bronchial fibroblasts, skin epithelial cells, hepatocytes, cerebral endothelial cells, fibrosarcoma cells, breast carcinoma cells, lung carcinoma cells, and cervix carcinoma cells. Other cell lines including the Chinese hamster ovary cells, mouse fibroblast cells, murine fibroblast cells, Mytilus galloprovincialis sperm cells, mice lung cells, murine alveolar macrophages, mice hepatic and renal tissue cells, and vero cells have also shown mutagenic effects upon exposure to IONPs. We further show the influence of IONPs on microorganisms in the presence and absence of dissolved organic carbon. The results shed light on the transformations IONPs undergo in the environment and the nature of the potential mutagenic impact on biological cells.

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“…The Al 2 O 3 is classied as a class 2 carcinogen that can induce DNA damage, whereas the Fe 2 O 3 and CaCO 3 have not been reported. 40,41 The median lethal dose through oral in rat (LD 50 ) for Al 2 O 3 was 2000 mg kg À1 , while the values (through oral or dermal in rat) for Fe 2 O 3 and CaCO 3 were 5000-10 000 and 20 000 mg kg À1 , respectively. 42 Furthermore, the Fe 2 O 3 might have a chronic aquatic toxicity, as many studies showed that the short-term toxicity of Fe 2 O 3 to aquatic algae EC50 was 100 mg L À1 .…”

Section: The Comparative Study Across Different Cb Toolsmentioning

confidence: 99%

Qualitative and quantitative differences between common control banding tools for nanomaterials in workplaces

et al. 2019

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Recent toxicological investigations of metal or metal oxide nanoparticles in mammalian models in vitro and in vivo: DNA damaging potential, and relevant physicochemical characteristics

Cited by 16 publications

References 118 publications

Human health no-effect levels of TiO2 nanoparticles as a function of their primary size

Human health no-effect levels of TiO2 nanoparticles as a function of their primary size

Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells

Qualitative and quantitative differences between common control banding tools for nanomaterials in workplaces

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