Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders

Aryaei, Ashkan; Vapniarsky, Natalia; Hu, Jerry C.; Athanasiou, Kyriacos A.

doi:10.1007/s11914-016-0327-y

Cited by 51 publications

(40 citation statements)

References 104 publications

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“…1 TMD management options vary with respect to disease severity, ranging from symptomatic therapy to invasive surgery. 5 Total joint replacement with prosthetics or TMJ disc removal are currently the only options available at late-stage TMD. 6 None of these treatments offer complete resolution and repeat or follow-up surgeries may be required.…”

Section: Introductionmentioning

confidence: 99%

The Yucatan Minipig Temporomandibular Joint Disc Structure–Function Relationships Support Its Suitability for Human Comparative Studies

Vapniarsky

Aryaei

Arzi

et al. 2017

Tissue Engineering Part C: Methods

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Frequent involvement of the disc in temporomandibular joint (TMJ) disorders warrants attempts to tissue engineer TMJ disc replacements. Physiologically, a great degree of similarity is seen between humans and farm pigs (FPs), but the pig's rapid growth confers a significant challenge for in vivo experiments. Minipigs have a slower growth rate and are smaller than FPs, but minipig TMJ discs have yet to be fully characterized. The objective of this study was to determine the suitability of the minipig for TMJ studies by extensive structural and functional characterization. The properties of minipig TMJ discs closely reproduced previously reported morphological, biochemical, and biomechanical values of human and FP discs. The width/length dimension ratio of the minipig TMJ disc was 1.95 (1.69 for human and 1.94 for FP). The biochemical evaluation revealed, on average per wet weight, 24.3% collagen (22.8% for human and 24.9% for FP); 0.8% glycosaminoglycan (GAG; 0.5% for human and 0.4% for FP); and 0.03% DNA (0.008% for human and 0.02% for FP). Biomechanical testing revealed, on average, compressive relaxation modulus of 50 kPa (37 kPa for human and 32 kPa for FP), compressive instantaneous modulus of 1121 kPa (1315 kPa for human and 1134 kPa for FP), and coefficient of viscosity of 13 MPa$s (9 MPa$s for human and 3 MPa$s for FP) at 20% strain. These properties also varied topographically in accordance to those of human and FP TMJ discs. Anisotropy, quantified by bidirectional tensile testing and histology, again was analogous among minipig, human, and FP TMJ discs. The minipig TMJ's ginglymoarthrodial nature was verified through cone beam computer tomography. Collectively, the similarities between minipig and human TMJ discs support the use of minipig as a relevant model for TMJ research; considering the practical advantages conferred by its growth rate and size, the minipig may be a preferred model over FP.

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Section: Introductionmentioning

confidence: 99%

The Yucatan Minipig Temporomandibular Joint Disc Structure–Function Relationships Support Its Suitability for Human Comparative Studies

Vapniarsky

Aryaei

Arzi

et al. 2017

Tissue Engineering Part C: Methods

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“…The temporomandibular joint links the condyloid process (mandibular bone) to the temporal bone. The cartilage disc is the middle of mandibular condyle and the glenoid fossa eminence of the temporal bone and separates the joint area into inferior and superior compartments, each of that area unit crammed with synovial fluid [79].…”

Section: Temporomandibular Joint Disordersmentioning

confidence: 99%

Tissue Engineering Applications in Maxillofacial Surgery

Keyhan¹,

Fallahi²,

Jahangirnia³

et al. 2018

Stem Cells in Clinical Practice and Tissue Engineering

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Nowadays, oral and maxillofacial surgeons face serious difficulties in reconstruction of large defects caused by trauma, cancer, or congenital deformities. Considering each part of oral and maxillofacial region consisting of several tissues, it is necessary to reconstruct these architectures layer by layer. Through years surgeons use different forms of grafts to reconstruct these defects. As these grafts and techniques are well described and used routinely, it should have been noticed that they are not without complications. This is where idea behind tissue engineering steps in. "Tissue engineering" due to its multi-aspect properties can be defined as application of methods and science of engineering toward the understanding of structure-function relationships of mammalian tissues in both normal and pathological forms to improve and develop biologic substitutes to reach the main goal of restoring, maintaining, and stabilization of tissue function. From standpoint of surgery, tissue engineering is not considered as a potential step anymore, but as an available approach to reach the ultimate goal of reconstruction procedures. The aim of this chapter is to defne concepts and advances in tissue engineering (TE). Also, review TE applications in the field of oral and maxillofacial surgery with bolding its clinical applications and complications based on novel and high-quality published researches.

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“…With the advances in the manufacturing techniques such as selective laser sintering and rapid prototyping should be helpful in bone tissue engineering applications. These techniques are widely used in the fabrication of temporomandibular joints [71], craniofacial [72] or periodontal structures [73]. The fabrication methodology allows the flexibility of the combination of different materials for increasing mechanical strength.…”

Section: Biomimetic Scaffold Fabricationmentioning

confidence: 99%

Fabrication Methodologies of Biomimetic and Bioactive Scaffolds for Tissue Engineering Applications

Prakasam¹,

Popescu²,

Piticescu³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Tissue engineering has offered wide technologies for developing functional biomaterials substitutes for repair and regeneration of damaged tissue and organs. Biomimetic materials with their inherent nature to mimic natural materials are possible through the recent advances in the fabrication technology. With the help of porous or dense implants made with biodegradable materials, it is possible to incorporate different vital growth factors, genes, drugs, stem cells and proteins. In this review, we presented various fabrication methodologies of biomimetic and bioactive scaffolds for tissue engineering applications. An overview of the nanocomposites of biomaterials is presented. Further an example of one of the hybrid nanocomposite material is given for additive manufacturing.

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Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders

Cited by 51 publications

References 104 publications

The Yucatan Minipig Temporomandibular Joint Disc Structure–Function Relationships Support Its Suitability for Human Comparative Studies

The Yucatan Minipig Temporomandibular Joint Disc Structure–Function Relationships Support Its Suitability for Human Comparative Studies

Tissue Engineering Applications in Maxillofacial Surgery

Fabrication Methodologies of Biomimetic and Bioactive Scaffolds for Tissue Engineering Applications

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