Recent theranostic paradigms for the management of Age-related macular degeneration

Suri, Reshal; Neupane, Yub Raj; Jain, Gaurav; Kohli, Kanchan

doi:10.1016/j.ejps.2020.105489

Cited by 14 publications

(7 citation statements)

References 160 publications

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“…MA progression is a gradually complicated process resulting in irreversible vision loss, and thus, early detection is essential for the development of novel therapis. Previous detection of MA was mainly based on CFP and FAF 6 , 27 – 29 . With the development of imaging technology, OCT has become a preferred imaging tool for assessment, especially combined with artificial intelligence (AI) 17 , 25 , 29 .…”

Section: Discussionmentioning

confidence: 99%

Deep learning to detect macular atrophy in wet age-related macular degeneration using optical coherence tomography

Wei

Southern

Zhu

et al. 2023

Sci Rep

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Here, we have developed a deep learning method to fully automatically detect and quantify six main clinically relevant atrophic features associated with macular atrophy (MA) using optical coherence tomography (OCT) analysis of patients with wet age-related macular degeneration (AMD). The development of MA in patients with AMD results in irreversible blindness, and there is currently no effective method of early diagnosis of this condition, despite the recent development of unique treatments. Using OCT dataset of a total of 2211 B-scans from 45 volumetric scans of 8 patients, a convolutional neural network using one-against-all strategy was trained to present all six atrophic features followed by a validation to evaluate the performance of the models. The model predictive performance has achieved a mean dice similarity coefficient score of 0.706 ± 0.039, a mean Precision score of 0.834 ± 0.048, and a mean Sensitivity score of 0.615 ± 0.051. These results show the unique potential of using artificially intelligence-aided methods for early detection and identification of the progression of MA in wet AMD, which can further support and assist clinical decisions.

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Section: Discussionmentioning

confidence: 99%

Deep learning to detect macular atrophy in wet age-related macular degeneration using optical coherence tomography

Wei

Southern

Zhu

et al. 2023

Sci Rep

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“…Alternatively, clinical trials studying stem cell therapy based on the transplantation of RPE cells for tissue damaged by CNV or tissue loss owing to geographic atrophy are underway [ 18 , 31 , 32 ]. Some of the supplements based on natural drugs and advised in patients with early AMD include InShape ® , Nutrof ® , Ocuvite ® , and Vitalux ® [ 33 ]. Regarding natural drugs proposed for the early-stage prevention of AMD, most of them are based on the oxidative stress as the main therapeutic target for the management of the disease [ 23 ].…”

Section: Amd Signs and Symptomsmentioning

confidence: 99%

“…The most widely investigated involves the use of embryonic stem cells in RPE transplantation (ESC-derived RPE cells) which has been reported to be without any serious adverse outcomes on visual acuity, visual field, static perimetry, electroretinography or reading speed, and there were no signs of acute rejection, even after four years. The alternative therapy is based on induced pluripotent stem cells in RPE transplantation (iPSC derived RPE transplants) [ 33 , 57 , 68 ]. In fact, RPE cells can be differentiated from pluripotent stem cells and be transplanted subretinally to treat macular degeneration ( Figure 3 ).…”

Section: Biological Therapies For the Treatment Of Amdmentioning

confidence: 99%

Therapeutic Approaches for Age-Related Macular Degeneration

Galindo

Blanco-Llamero

Ana

et al. 2022

IJMS

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Damage to the retinal pigment epithelium, Bruch’s membrane and/or tissues underlying macula is known to increase the risk of age-related macular degeneration (AMD). AMD is commonly categorized in two distinct types, namely, the nonexudative (dry form) and the exudative (wet form). Currently, there is no ideal treatment available for AMD. Recommended standard treatments are based on the use of vascular endothelial growth factor (VEGF), with the disadvantage of requiring repeated intravitreal injections which hinder patient’s compliance to the therapy. In recent years, several synthetic and natural active compounds have been proposed as innovative therapeutic strategies against this disease. There is a growing interest in the development of formulations based on nanotechnology because of its important role in the management of posterior eye segment disorders, without the use of intravitreal injections, and furthermore, with the potential to prolong drug release and thus reduce adverse effects. In the same way, 3D bioprinting constitutes an alternative to regeneration therapies for the human retina to restore its functions. The application of 3D bioprinting may change the current and future perspectives of the treatment of patients with AMD, especially those who do not respond to conventional treatment. To monitor the progress of AMD treatment and disease, retinal images are used. In this work, we revised the recent challenges encountered in the treatment of different forms of AMD, innovative nanoformulations, 3D bioprinting, and techniques to monitor the progress.

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“…Nevertheless, when faced with minimal or noninvasive criteria, magnetic hydrogels employed as bulk materials may be at a disadvantage . In contrast, magnetic micro/nanohydrogels can be injected using tiny needles or catheters for noninvasive delivery of biologics and cells due to their small sizes and deformability …”

Section: Introductionmentioning

confidence: 99%

“…42 In contrast, magnetic micro/nanohydrogels can be injected using tiny needles or catheters for noninvasive delivery of biologics and cells due to their small sizes and deformability. 43 In this work, we adopt a two-step strategy to fabricate IONP-impregnated copolymer hydrogel with magnetic responsiveness and tunable payload release. Initially, maghemite nanoparticles (γ-Fe 2 O 3 ) were synthesized using the roomtemperature layer-by-layer deposition approach, which has been previously employed by our team.…”

Section: ■ Introductionmentioning

confidence: 99%

Superparamagnetic Amine-Functionalized Maghemite Nanoparticles as a Thixotropy Promoter for Hydrogels and Magnetic Field-Driven Diffusion-Controlled Drug Release

Ganguly,

Das,

Srinivasan

et al. 2024

ACS Appl. Nano Mater.

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Superparamagnetic nanoparticle-arrested hydrogel matrices have immense significance in smart soft biomaterials. Herein, we report the synthesis of superparamagnetic nanoparticle-loaded magneto-responsive tough elastomeric hydrogels for dual-responsive drug delivery. In the first phase of work, we carried out roomtemperature synthesis of amine-functionalized superparamagnetic iron oxide nanoparticles (IONPs), and in the second phase of work, we demonstrated that IONPs could act as a toughening agent as well as a viscosity modifier for poly(acrylic acid-co-hydroxyethyl methacrylate) copolymer hydrogels. The hydrogel was tested by Fourier transformed infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and continuous-wave-electron paramagnetic resonance (CW-EPR). Moreover, the IONPs affect its gelation time and elasticity significantly, which was also evaluated from its rheological behavior. The compressive mechanical strength (∼120 kPa), elasticity, recovery to original shape (zero permanent set), water uptake, and thixotropic behavior under dynamic stress of the hybrid hydrogels have supported its robustness in the swelled state. The drug release behavior of the hydrogel showed dual parameter dependency (IONPs and cross-linker) and dual responsiveness against both pH and static magnetic field. The delayed network rupturing, dualresponsive drug delivery nature, and noncytotoxic behavior against human live cells could promote this hybrid hydrogel as an ideal alternative for the remotely controlled drug delivery vehicle.

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Recent theranostic paradigms for the management of Age-related macular degeneration

Cited by 14 publications

References 160 publications

Deep learning to detect macular atrophy in wet age-related macular degeneration using optical coherence tomography

Deep learning to detect macular atrophy in wet age-related macular degeneration using optical coherence tomography

Therapeutic Approaches for Age-Related Macular Degeneration

Superparamagnetic Amine-Functionalized Maghemite Nanoparticles as a Thixotropy Promoter for Hydrogels and Magnetic Field-Driven Diffusion-Controlled Drug Release

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