Recent technological advancements in radiofrequency- andmicrowave-mediated hyperthermia for enhancing drug delivery

Paulides, Margarethus M.; Trefná, Hana Dobšíček; Curto, Sergio; Rodrigues, Dário B.

doi:10.1016/j.addr.2020.03.004

Cited by 84 publications

(66 citation statements)

References 149 publications

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“…double-strand breaks) generated by chemotherapy or radiotherapy [166]. Several clinical trials involving the use of hyperthermia as adjuvant for chemotherapy are ongoing [167]. An example is the use of a near-infraredresponsive polypeptide nanocomposites charged with doxorubicin and capable of heat generation and heatsensitive nitric oxide (NO) gas delivery [168].…”

Section: Exploiting Intrinsic Physical Propertiesmentioning

confidence: 99%

Delivery of cancer therapies by synthetic and bio-inspired nanovectors

et al. 2021

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Background As a complement to the clinical development of new anticancer molecules, innovations in therapeutic vectorization aim at solving issues related to tumor specificity and associated toxicities. Nanomedicine is a rapidly evolving field that offers various solutions to increase clinical efficacy and safety. Main Here are presented the recent advances for different types of nanovectors of chemical and biological nature, to identify the best suited for translational research projects. These nanovectors include different types of chemically engineered nanoparticles that now come in many different flavors of ‘smart’ drug delivery systems. Alternatives with enhanced biocompatibility and a better adaptability to new types of therapeutic molecules are the cell-derived extracellular vesicles and micro-organism-derived oncolytic viruses, virus-like particles and bacterial minicells. In the first part of the review, we describe their main physical, chemical and biological properties and their potential for personalized modifications. The second part focuses on presenting the recent literature on the use of the different families of nanovectors to deliver anticancer molecules for chemotherapy, radiotherapy, nucleic acid-based therapy, modulation of the tumor microenvironment and immunotherapy. Conclusion This review will help the readers to better appreciate the complexity of available nanovectors and to identify the most fitting “type” for efficient and specific delivery of diverse anticancer therapies.

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Section: Exploiting Intrinsic Physical Propertiesmentioning

confidence: 99%

Delivery of cancer therapies by synthetic and bio-inspired nanovectors

et al. 2021

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“…Tumor heating can be induced by a variety of external or interstitial techniques, including radiative radiofrequency (RF), microwave (MW), infrared, capacitive, high intensity focused ultrasound (HIFU) and scanned focused ultrasound (SFUS) devices [8,9]. Treatment approaches are subdivided into three broad categories: local, locoregional, or whole body heating.…”

Section: Introductionmentioning

confidence: 99%

Treatment planning facilitates clinical decision making for hyperthermia treatments

Kok

Zee

Guirado

et al. 2021

International Journal of Hyperthermia

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Background: Treatment quality is important in clinical hyperthermia. Guideline-based treatment protocols are used to determine system settings and treatment strategies to ensure effective tumor heating and prevent unwanted treatment-limiting normal tissue hot spots. Realizing both these goals can prove challenging using generic guideline-based and operator-dependent treatment strategies. Hyperthermia treatment planning (HTP) can be very useful to support treatment strategies. Although HTP is increasingly integrated into the standard clinical workflow, active clinical application is still limited to a small number of hyperthermia centers and should be further stimulated. Purpose: This paper aims to serve as a practical guide, demonstrating how HTP can be applied in clinical decision making for both superficial and locoregional hyperthermia treatments. HTP in clinical decision making: Seven problems that occur in daily clinical practice are described and we show how HTP can enhance insight to formulate an adequate treatment strategy. Examples use representative commercially available hyperthermia devices and cover all stages during the clinical workflow. Problems include selecting adequate phase settings, heating ability analysis, hot spot suppression, applicator selection, evaluation of target coverage and heating depth, and predicting possible thermal toxicity in case of an implant. Since we aim to promote a general use of HTP in daily practice, basic simulation strategies are used in these problems, avoiding a need for the application of dedicated advanced optimization routines that are not generally available. Conclusion: Even fairly basic HTP can facilitate clinical decision making, providing a meaningful and clinically relevant contribution to maintaining and improving treatment quality.

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“…In this manuscript, we present calculations for spherical and spheroidal metal nanoparticles in a variety of tissues that have been commonly treated with RF and/or microwave hyperthermia in clinical trials [1,2]. We consider particles ranging in size from nanometers to tens of microns across the frequency spectrum from 1 MHz to 10 GHz, covering the operating frequencies of nearly all hyperthermia treatments [1,2]. The main novelty of this work over existing studies is three-fold: first, when considering the electronic response of nanoparticles to incident radiation, we scan over a parameter space of realistic values that can be achieved by synthesizing metal nanostructures with reported methods.…”

Section: Introductionmentioning

confidence: 99%

Differential heating of metal nanostructures by radio frequencies: a theoretical study

Rommelfanger

et al. 2021

Preprint

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Nanoparticles with strong absorption of incident radio frequency (RF) or microwave irradiation are desirable for remote hyperthermia treatments. While controversy has surrounded the absorption properties of spherical metallic nanoparticles, other geometries such as prolate and oblate spheroids have not received sufficient attention for application in hyperthermia therapies. Here, we use the electrostatic approximation to calculate the relative absorption ratio of metallic nanoparticles in various biological tissues. We consider a broad parameter space, sweeping across frequencies from 1 MHz to 10 GHz, while also tuning the nanoparticle dimensions from spheres to high-aspect-ratio spheroids approximating nanowires and nanodiscs. We find that while spherical metallic nanoparticles do not offer differential heating in tissue, large absorption cross sections can be obtained from long prolate spheroids, while thin oblate spheroids offer minor potential for absorption. Our results suggest that metallic nanowires should be considered for RF- and microwave-based wireless hyperthermia treatments in many tissues going forward.

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Recent technological advancements in radiofrequency- andmicrowave-mediated hyperthermia for enhancing drug delivery

Cited by 84 publications

References 149 publications

Delivery of cancer therapies by synthetic and bio-inspired nanovectors

Delivery of cancer therapies by synthetic and bio-inspired nanovectors

Treatment planning facilitates clinical decision making for hyperthermia treatments

Differential heating of metal nanostructures by radio frequencies: a theoretical study

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